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Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity

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Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity. / Heck, Angela; Fastenrath, Matthias; Ackermann, Sandra; Auschra, Bianca; Bickel, Horst; Coynel, David; Gschwind, Leo; Jessen, Frank; Kaduszkiewicz, Hanna; Maier, Wolfgang; Milnik, Annette; Pentzek, Michael; Riedel-Heller, Steffi G; Ripke, Stephan; Spalek, Klara; Sullivan, Patrick; Vogler, Christian; Wagner, Michael; Weyerer, Siegfried; Wolfsgruber, Steffen; de Quervain, Dominique J-F; Papassotiropoulos, Andreas.

in: NEURON, Jahrgang 81, Nr. 5, 05.03.2014, S. 1203-13.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Heck, A, Fastenrath, M, Ackermann, S, Auschra, B, Bickel, H, Coynel, D, Gschwind, L, Jessen, F, Kaduszkiewicz, H, Maier, W, Milnik, A, Pentzek, M, Riedel-Heller, SG, Ripke, S, Spalek, K, Sullivan, P, Vogler, C, Wagner, M, Weyerer, S, Wolfsgruber, S, de Quervain, DJ-F & Papassotiropoulos, A 2014, 'Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity', NEURON, Jg. 81, Nr. 5, S. 1203-13. https://doi.org/10.1016/j.neuron.2014.01.010

APA

Heck, A., Fastenrath, M., Ackermann, S., Auschra, B., Bickel, H., Coynel, D., Gschwind, L., Jessen, F., Kaduszkiewicz, H., Maier, W., Milnik, A., Pentzek, M., Riedel-Heller, S. G., Ripke, S., Spalek, K., Sullivan, P., Vogler, C., Wagner, M., Weyerer, S., ... Papassotiropoulos, A. (2014). Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity. NEURON, 81(5), 1203-13. https://doi.org/10.1016/j.neuron.2014.01.010

Vancouver

Heck A, Fastenrath M, Ackermann S, Auschra B, Bickel H, Coynel D et al. Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity. NEURON. 2014 Mär 5;81(5):1203-13. https://doi.org/10.1016/j.neuron.2014.01.010

Bibtex

@article{b234d444207d4f0382907aa4ca2fc384,
title = "Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity",
abstract = "Working memory, the capacity of actively maintaining task-relevant information during a cognitive task, is a heritable trait. Working memory deficits are characteristic for many psychiatric disorders. We performed genome-wide gene set enrichment analyses in multiple independent data sets of young and aged cognitively healthy subjects (n = 2,824) and in a large schizophrenia case-control sample (n = 32,143). The voltage-gated cation channel activity gene set, consisting of genes related to neuronal excitability, was robustly linked to performance in working memory-related tasks across ages and to schizophrenia. Functional brain imaging in 707 healthy participants linked this gene set also to working memory-related activity in the parietal cortex and the cerebellum. Gene set analyses may help to dissect the molecular underpinnings of cognitive dimensions, brain activity, and psychopathology.",
keywords = "Adult, Aged, Algorithms, Brain, Calcium Channels, Case-Control Studies, Cerebellum, Cognition, Female, Genome-Wide Association Study, Healthy Volunteers, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Parietal Lobe, Prefrontal Cortex, Schizophrenia, Young Adult",
author = "Angela Heck and Matthias Fastenrath and Sandra Ackermann and Bianca Auschra and Horst Bickel and David Coynel and Leo Gschwind and Frank Jessen and Hanna Kaduszkiewicz and Wolfgang Maier and Annette Milnik and Michael Pentzek and Riedel-Heller, {Steffi G} and Stephan Ripke and Klara Spalek and Patrick Sullivan and Christian Vogler and Michael Wagner and Siegfried Weyerer and Steffen Wolfsgruber and {de Quervain}, {Dominique J-F} and Andreas Papassotiropoulos",
note = "Copyright {\textcopyright} 2014 Elsevier Inc. All rights reserved.",
year = "2014",
month = mar,
day = "5",
doi = "10.1016/j.neuron.2014.01.010",
language = "English",
volume = "81",
pages = "1203--13",
journal = "NEURON",
issn = "0896-6273",
publisher = "Cell Press",
number = "5",

}

RIS

TY - JOUR

T1 - Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity

AU - Heck, Angela

AU - Fastenrath, Matthias

AU - Ackermann, Sandra

AU - Auschra, Bianca

AU - Bickel, Horst

AU - Coynel, David

AU - Gschwind, Leo

AU - Jessen, Frank

AU - Kaduszkiewicz, Hanna

AU - Maier, Wolfgang

AU - Milnik, Annette

AU - Pentzek, Michael

AU - Riedel-Heller, Steffi G

AU - Ripke, Stephan

AU - Spalek, Klara

AU - Sullivan, Patrick

AU - Vogler, Christian

AU - Wagner, Michael

AU - Weyerer, Siegfried

AU - Wolfsgruber, Steffen

AU - de Quervain, Dominique J-F

AU - Papassotiropoulos, Andreas

N1 - Copyright © 2014 Elsevier Inc. All rights reserved.

PY - 2014/3/5

Y1 - 2014/3/5

N2 - Working memory, the capacity of actively maintaining task-relevant information during a cognitive task, is a heritable trait. Working memory deficits are characteristic for many psychiatric disorders. We performed genome-wide gene set enrichment analyses in multiple independent data sets of young and aged cognitively healthy subjects (n = 2,824) and in a large schizophrenia case-control sample (n = 32,143). The voltage-gated cation channel activity gene set, consisting of genes related to neuronal excitability, was robustly linked to performance in working memory-related tasks across ages and to schizophrenia. Functional brain imaging in 707 healthy participants linked this gene set also to working memory-related activity in the parietal cortex and the cerebellum. Gene set analyses may help to dissect the molecular underpinnings of cognitive dimensions, brain activity, and psychopathology.

AB - Working memory, the capacity of actively maintaining task-relevant information during a cognitive task, is a heritable trait. Working memory deficits are characteristic for many psychiatric disorders. We performed genome-wide gene set enrichment analyses in multiple independent data sets of young and aged cognitively healthy subjects (n = 2,824) and in a large schizophrenia case-control sample (n = 32,143). The voltage-gated cation channel activity gene set, consisting of genes related to neuronal excitability, was robustly linked to performance in working memory-related tasks across ages and to schizophrenia. Functional brain imaging in 707 healthy participants linked this gene set also to working memory-related activity in the parietal cortex and the cerebellum. Gene set analyses may help to dissect the molecular underpinnings of cognitive dimensions, brain activity, and psychopathology.

KW - Adult

KW - Aged

KW - Algorithms

KW - Brain

KW - Calcium Channels

KW - Case-Control Studies

KW - Cerebellum

KW - Cognition

KW - Female

KW - Genome-Wide Association Study

KW - Healthy Volunteers

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Memory, Short-Term

KW - Parietal Lobe

KW - Prefrontal Cortex

KW - Schizophrenia

KW - Young Adult

U2 - 10.1016/j.neuron.2014.01.010

DO - 10.1016/j.neuron.2014.01.010

M3 - SCORING: Journal article

C2 - 24529980

VL - 81

SP - 1203

EP - 1213

JO - NEURON

JF - NEURON

SN - 0896-6273

IS - 5

ER -