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Converging evidence for an impact of a functional NOS gene variation on anxiety-related processes

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Converging evidence for an impact of a functional NOS gene variation on anxiety-related processes. / Kuhn, Manuel; Haaker, Jan; Glotzbach-Schoon, Evelyn; Schümann, Dirk; Andreatta, Marta; Mechias, Marie-Luise; Raczka, Karolina; Gartmann, Nina; Büchel, Christian; Mühlberger, Andreas; Pauli, Paul; Reif, Andreas; Kalisch, Raffael; Lonsdorf, Tina B.

in: SOC COGN AFFECT NEUR, Jahrgang 11, Nr. 5, 05.2016, S. 803-12.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kuhn, M, Haaker, J, Glotzbach-Schoon, E, Schümann, D, Andreatta, M, Mechias, M-L, Raczka, K, Gartmann, N, Büchel, C, Mühlberger, A, Pauli, P, Reif, A, Kalisch, R & Lonsdorf, TB 2016, 'Converging evidence for an impact of a functional NOS gene variation on anxiety-related processes', SOC COGN AFFECT NEUR, Jg. 11, Nr. 5, S. 803-12. https://doi.org/10.1093/scan/nsv151

APA

Kuhn, M., Haaker, J., Glotzbach-Schoon, E., Schümann, D., Andreatta, M., Mechias, M-L., Raczka, K., Gartmann, N., Büchel, C., Mühlberger, A., Pauli, P., Reif, A., Kalisch, R., & Lonsdorf, T. B. (2016). Converging evidence for an impact of a functional NOS gene variation on anxiety-related processes. SOC COGN AFFECT NEUR, 11(5), 803-12. https://doi.org/10.1093/scan/nsv151

Vancouver

Kuhn M, Haaker J, Glotzbach-Schoon E, Schümann D, Andreatta M, Mechias M-L et al. Converging evidence for an impact of a functional NOS gene variation on anxiety-related processes. SOC COGN AFFECT NEUR. 2016 Mai;11(5):803-12. https://doi.org/10.1093/scan/nsv151

Bibtex

@article{b8d64bdb51bb4f06a54e5802e5ed9fa2,
title = "Converging evidence for an impact of a functional NOS gene variation on anxiety-related processes",
abstract = "Being a complex phenotype with substantial heritability, anxiety and related phenotypes are characterized by a complex polygenic basis. Thereby, one candidate pathway is neuronal nitric oxide (NO) signaling, and accordingly, rodent studies have identified NO synthase (NOS-I), encoded by NOS1, as a strong molecular candidate for modulating anxiety and hippocampus-dependent learning processes. Using a multi-dimensional and -methodological replication approach, we investigated the impact of a functional promoter polymorphism (NOS1-ex1f-VNTR) on human anxiety-related phenotypes in a total of 1019 healthy controls in five different studies. Homozygous carriers of the NOS1-ex1f short-allele displayed enhanced trait anxiety, worrying and depression scores. Furthermore, short-allele carriers were characterized by increased anxious apprehension during contextual fear conditioning. While autonomous measures (fear-potentiated startle) provided only suggestive evidence for a modulatory role of NOS1-ex1f-VNTR on (contextual) fear conditioning processes, neural activation at the amygdala/anterior hippocampus junction was significantly increased in short-allele carriers during context conditioning. Notably, this could not be attributed to morphological differences. In accordance with data from a plethora of rodent studies, we here provide converging evidence from behavioral, subjective, psychophysiological and neuroimaging studies in large human cohorts that NOS-I plays an important role in anxious apprehension but provide only limited evidence for a role in (contextual) fear conditioning.",
keywords = "Journal Article",
author = "Manuel Kuhn and Jan Haaker and Evelyn Glotzbach-Schoon and Dirk Sch{\"u}mann and Marta Andreatta and Marie-Luise Mechias and Karolina Raczka and Nina Gartmann and Christian B{\"u}chel and Andreas M{\"u}hlberger and Paul Pauli and Andreas Reif and Raffael Kalisch and Lonsdorf, {Tina B}",
note = "{\textcopyright} The Author (2016). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.",
year = "2016",
month = may,
doi = "10.1093/scan/nsv151",
language = "English",
volume = "11",
pages = "803--12",
journal = "SOC COGN AFFECT NEUR",
issn = "1749-5016",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Converging evidence for an impact of a functional NOS gene variation on anxiety-related processes

AU - Kuhn, Manuel

AU - Haaker, Jan

AU - Glotzbach-Schoon, Evelyn

AU - Schümann, Dirk

AU - Andreatta, Marta

AU - Mechias, Marie-Luise

AU - Raczka, Karolina

AU - Gartmann, Nina

AU - Büchel, Christian

AU - Mühlberger, Andreas

AU - Pauli, Paul

AU - Reif, Andreas

AU - Kalisch, Raffael

AU - Lonsdorf, Tina B

N1 - © The Author (2016). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

PY - 2016/5

Y1 - 2016/5

N2 - Being a complex phenotype with substantial heritability, anxiety and related phenotypes are characterized by a complex polygenic basis. Thereby, one candidate pathway is neuronal nitric oxide (NO) signaling, and accordingly, rodent studies have identified NO synthase (NOS-I), encoded by NOS1, as a strong molecular candidate for modulating anxiety and hippocampus-dependent learning processes. Using a multi-dimensional and -methodological replication approach, we investigated the impact of a functional promoter polymorphism (NOS1-ex1f-VNTR) on human anxiety-related phenotypes in a total of 1019 healthy controls in five different studies. Homozygous carriers of the NOS1-ex1f short-allele displayed enhanced trait anxiety, worrying and depression scores. Furthermore, short-allele carriers were characterized by increased anxious apprehension during contextual fear conditioning. While autonomous measures (fear-potentiated startle) provided only suggestive evidence for a modulatory role of NOS1-ex1f-VNTR on (contextual) fear conditioning processes, neural activation at the amygdala/anterior hippocampus junction was significantly increased in short-allele carriers during context conditioning. Notably, this could not be attributed to morphological differences. In accordance with data from a plethora of rodent studies, we here provide converging evidence from behavioral, subjective, psychophysiological and neuroimaging studies in large human cohorts that NOS-I plays an important role in anxious apprehension but provide only limited evidence for a role in (contextual) fear conditioning.

AB - Being a complex phenotype with substantial heritability, anxiety and related phenotypes are characterized by a complex polygenic basis. Thereby, one candidate pathway is neuronal nitric oxide (NO) signaling, and accordingly, rodent studies have identified NO synthase (NOS-I), encoded by NOS1, as a strong molecular candidate for modulating anxiety and hippocampus-dependent learning processes. Using a multi-dimensional and -methodological replication approach, we investigated the impact of a functional promoter polymorphism (NOS1-ex1f-VNTR) on human anxiety-related phenotypes in a total of 1019 healthy controls in five different studies. Homozygous carriers of the NOS1-ex1f short-allele displayed enhanced trait anxiety, worrying and depression scores. Furthermore, short-allele carriers were characterized by increased anxious apprehension during contextual fear conditioning. While autonomous measures (fear-potentiated startle) provided only suggestive evidence for a modulatory role of NOS1-ex1f-VNTR on (contextual) fear conditioning processes, neural activation at the amygdala/anterior hippocampus junction was significantly increased in short-allele carriers during context conditioning. Notably, this could not be attributed to morphological differences. In accordance with data from a plethora of rodent studies, we here provide converging evidence from behavioral, subjective, psychophysiological and neuroimaging studies in large human cohorts that NOS-I plays an important role in anxious apprehension but provide only limited evidence for a role in (contextual) fear conditioning.

KW - Journal Article

U2 - 10.1093/scan/nsv151

DO - 10.1093/scan/nsv151

M3 - SCORING: Journal article

C2 - 26746182

VL - 11

SP - 803

EP - 812

JO - SOC COGN AFFECT NEUR

JF - SOC COGN AFFECT NEUR

SN - 1749-5016

IS - 5

ER -