Control conditions for randomised trials of behavioural interventions in psychiatry: a decision framework

Stefan M Gold; Paul Enck; Helge Hasselmann; Tim Friede; Ulrich Hegerl; David C Mohr; Christian Otte

doi:10.1016/S2215-0366(17)30153-0

Control conditions for randomised trials of behavioural interventions in psychiatry: a decision framework

Standard

Control conditions for randomised trials of behavioural interventions in psychiatry: a decision framework. / Gold, Stefan M; Enck, Paul; Hasselmann, Helge; Friede, Tim; Hegerl, Ulrich; Mohr, David C; Otte, Christian.

in: LANCET PSYCHIAT, Jahrgang 4, Nr. 9, 09.2017, S. 725-732.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gold, SM, Enck, P, Hasselmann, H, Friede, T, Hegerl, U, Mohr, DC & Otte, C 2017, 'Control conditions for randomised trials of behavioural interventions in psychiatry: a decision framework', LANCET PSYCHIAT, Jg. 4, Nr. 9, S. 725-732. https://doi.org/10.1016/S2215-0366(17)30153-0

APA

Gold, S. M., Enck, P., Hasselmann, H., Friede, T., Hegerl, U., Mohr, D. C., & Otte, C. (2017). Control conditions for randomised trials of behavioural interventions in psychiatry: a decision framework. LANCET PSYCHIAT, 4(9), 725-732. https://doi.org/10.1016/S2215-0366(17)30153-0

Vancouver

Gold SM, Enck P, Hasselmann H, Friede T, Hegerl U, Mohr DC et al. Control conditions for randomised trials of behavioural interventions in psychiatry: a decision framework. LANCET PSYCHIAT. 2017 Sep;4(9):725-732. https://doi.org/10.1016/S2215-0366(17)30153-0

Bibtex

@article{5a33946df3cc4e3fa8eca089eec951ef,

title = "Control conditions for randomised trials of behavioural interventions in psychiatry: a decision framework",

abstract = "In psychiatry, comparative analyses of therapeutic options and the aggregation of data from clinical trials across different therapeutic approaches play an important role in clinical decision making, treatment guidelines, and health policy. This approach assumes that trials of pharmacological and behavioural therapies generally produce the same level of evidence when properly designed. However, trial design for behavioural interventions has some unique characteristics and control groups vary widely, which influence the effects observed in any given trial. In this Personal View, we review various control conditions typically used in psychiatry, outline their effect on the internal validity and expected effect size of a trial, and propose a decision framework for choosing a control condition depending on the risk to the patient population and the stage of development of the therapeutic intervention. We argue that the choice of control group and its justification need to be taken into consideration when comparing behavioural and pharmacological therapies.",

keywords = "Journal Article, Review",

author = "Gold, {Stefan M} and Paul Enck and Helge Hasselmann and Tim Friede and Ulrich Hegerl and Mohr, {David C} and Christian Otte",

year = "2017",

month = sep,

doi = "10.1016/S2215-0366(17)30153-0",

language = "English",

volume = "4",

pages = "725--732",

journal = "LANCET PSYCHIAT",

issn = "2215-0374",

publisher = "Elsevier Limited",

number = "9",

}

RIS

TY - JOUR

T1 - Control conditions for randomised trials of behavioural interventions in psychiatry: a decision framework

AU - Gold, Stefan M

AU - Enck, Paul

AU - Hasselmann, Helge

AU - Friede, Tim

AU - Hegerl, Ulrich

AU - Mohr, David C

AU - Otte, Christian

PY - 2017/9

Y1 - 2017/9

N2 - In psychiatry, comparative analyses of therapeutic options and the aggregation of data from clinical trials across different therapeutic approaches play an important role in clinical decision making, treatment guidelines, and health policy. This approach assumes that trials of pharmacological and behavioural therapies generally produce the same level of evidence when properly designed. However, trial design for behavioural interventions has some unique characteristics and control groups vary widely, which influence the effects observed in any given trial. In this Personal View, we review various control conditions typically used in psychiatry, outline their effect on the internal validity and expected effect size of a trial, and propose a decision framework for choosing a control condition depending on the risk to the patient population and the stage of development of the therapeutic intervention. We argue that the choice of control group and its justification need to be taken into consideration when comparing behavioural and pharmacological therapies.

AB - In psychiatry, comparative analyses of therapeutic options and the aggregation of data from clinical trials across different therapeutic approaches play an important role in clinical decision making, treatment guidelines, and health policy. This approach assumes that trials of pharmacological and behavioural therapies generally produce the same level of evidence when properly designed. However, trial design for behavioural interventions has some unique characteristics and control groups vary widely, which influence the effects observed in any given trial. In this Personal View, we review various control conditions typically used in psychiatry, outline their effect on the internal validity and expected effect size of a trial, and propose a decision framework for choosing a control condition depending on the risk to the patient population and the stage of development of the therapeutic intervention. We argue that the choice of control group and its justification need to be taken into consideration when comparing behavioural and pharmacological therapies.

KW - Journal Article

KW - Review

U2 - 10.1016/S2215-0366(17)30153-0

DO - 10.1016/S2215-0366(17)30153-0

M3 - SCORING: Journal article

C2 - 28396067

VL - 4

SP - 725

EP - 732

JO - LANCET PSYCHIAT

JF - LANCET PSYCHIAT

SN - 2215-0374

IS - 9

ER -