Contributions of the cerebellum to disturbed central processing of visceral stimuli in irritable bowel syndrome
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Contributions of the cerebellum to disturbed central processing of visceral stimuli in irritable bowel syndrome. / Rosenberger, Christina; Thürling, Markus; Forsting, Michael; Elsenbruch, Sigrid; Timmann, Dagmar; Gizewski, Elke R.
in: CEREBELLUM, Jahrgang 12, Nr. 2, 04.2013, S. 194-8.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Contributions of the cerebellum to disturbed central processing of visceral stimuli in irritable bowel syndrome
AU - Rosenberger, Christina
AU - Thürling, Markus
AU - Forsting, Michael
AU - Elsenbruch, Sigrid
AU - Timmann, Dagmar
AU - Gizewski, Elke R
PY - 2013/4
Y1 - 2013/4
N2 - There is evidence to support that the cerebellum contributes to the neural processing of both emotions and painful stimuli. This could be particularly relevant in conditions associated with chronic abdominal pain, such as the irritable bowel syndrome (IBS), which are often also characterized by affective disturbances. We aimed to test the hypothesis that in IBS, symptoms of anxiety and depression modulate brain activation during visceral stimulation within the cerebellum. We reanalyzed a previous data set from N = 15 female IBS patients and N = 12 healthy women with a specific focus on the cerebellum using advanced normalization methods. Rectal distension-induced brain activation was measured with functional magnetic resonance imaging using non-painful and painful rectal distensions. Symptoms of anxiety and depression, assessed with the Hospital Anxiety and Depression scale, were correlated with cerebellar activation within IBS patients. Within IBS, depression scores were associated with non-painful distension-induced activation in the right cerebellum primarily in Crus II and lobule VIIIb, and additionally in Crus I. Depression scores were also associated with painful distension-induced activation predominantly in vermal lobule V with some extension to the intermediate cerebellum. Anxiety scores correlated significantly with non-painful induced activation in Crus II. Symptoms of anxiety and depression, which are frequently found in chronic pain conditions like IBS, modulate activation during visceral sensory signals not only in cortical and subcortical brain areas but also in the cerebellum.
AB - There is evidence to support that the cerebellum contributes to the neural processing of both emotions and painful stimuli. This could be particularly relevant in conditions associated with chronic abdominal pain, such as the irritable bowel syndrome (IBS), which are often also characterized by affective disturbances. We aimed to test the hypothesis that in IBS, symptoms of anxiety and depression modulate brain activation during visceral stimulation within the cerebellum. We reanalyzed a previous data set from N = 15 female IBS patients and N = 12 healthy women with a specific focus on the cerebellum using advanced normalization methods. Rectal distension-induced brain activation was measured with functional magnetic resonance imaging using non-painful and painful rectal distensions. Symptoms of anxiety and depression, assessed with the Hospital Anxiety and Depression scale, were correlated with cerebellar activation within IBS patients. Within IBS, depression scores were associated with non-painful distension-induced activation in the right cerebellum primarily in Crus II and lobule VIIIb, and additionally in Crus I. Depression scores were also associated with painful distension-induced activation predominantly in vermal lobule V with some extension to the intermediate cerebellum. Anxiety scores correlated significantly with non-painful induced activation in Crus II. Symptoms of anxiety and depression, which are frequently found in chronic pain conditions like IBS, modulate activation during visceral sensory signals not only in cortical and subcortical brain areas but also in the cerebellum.
KW - Adult
KW - Anxiety
KW - Cerebellum
KW - Depression
KW - Female
KW - Functional Laterality
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Irritable Bowel Syndrome
KW - Magnetic Resonance Imaging
KW - Middle Aged
KW - Oxygen
KW - Photic Stimulation
KW - Psychiatric Status Rating Scales
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1007/s12311-012-0413-3
DO - 10.1007/s12311-012-0413-3
M3 - SCORING: Journal article
C2 - 22910984
VL - 12
SP - 194
EP - 198
JO - CEREBELLUM
JF - CEREBELLUM
SN - 1473-4222
IS - 2
ER -