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Contemporary Pathological Stage Distribution After Radical Prostatectomy in North American High-Risk Prostate Cancer Patients

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Contemporary Pathological Stage Distribution After Radical Prostatectomy in North American High-Risk Prostate Cancer Patients. / Chierigo, Francesco; Borghesi, Marco; Würnschimmel, Christoph; Flammia, Rocco Simone; Sorce, Gabriele; Hoeh, Benedikt; Hohenhorst, Lukas; Tian, Zhe; Saad, Fred; Tilki, Derya; Gallucci, Michele; Briganti, Alberto; Montorsi, Francesco; Chun, Felix K H; Shariat, Shahrokh F; Mantica, Guglielmo; Suardi, Nazareno; Terrone, Carlo; Karakiewicz, Pierre I.

in: CLIN GENITOURIN CANC, Jahrgang 20, Nr. 5, 10.2022, S. e380-e389.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Chierigo, F, Borghesi, M, Würnschimmel, C, Flammia, RS, Sorce, G, Hoeh, B, Hohenhorst, L, Tian, Z, Saad, F, Tilki, D, Gallucci, M, Briganti, A, Montorsi, F, Chun, FKH, Shariat, SF, Mantica, G, Suardi, N, Terrone, C & Karakiewicz, PI 2022, 'Contemporary Pathological Stage Distribution After Radical Prostatectomy in North American High-Risk Prostate Cancer Patients', CLIN GENITOURIN CANC, Jg. 20, Nr. 5, S. e380-e389. https://doi.org/10.1016/j.clgc.2022.04.005

APA

Chierigo, F., Borghesi, M., Würnschimmel, C., Flammia, R. S., Sorce, G., Hoeh, B., Hohenhorst, L., Tian, Z., Saad, F., Tilki, D., Gallucci, M., Briganti, A., Montorsi, F., Chun, F. K. H., Shariat, S. F., Mantica, G., Suardi, N., Terrone, C., & Karakiewicz, P. I. (2022). Contemporary Pathological Stage Distribution After Radical Prostatectomy in North American High-Risk Prostate Cancer Patients. CLIN GENITOURIN CANC, 20(5), e380-e389. https://doi.org/10.1016/j.clgc.2022.04.005

Vancouver

Chierigo F, Borghesi M, Würnschimmel C, Flammia RS, Sorce G, Hoeh B et al. Contemporary Pathological Stage Distribution After Radical Prostatectomy in North American High-Risk Prostate Cancer Patients. CLIN GENITOURIN CANC. 2022 Okt;20(5):e380-e389. https://doi.org/10.1016/j.clgc.2022.04.005

Bibtex

@article{a88abcc3a6f049dbada6f2d94f4db4c8,
title = "Contemporary Pathological Stage Distribution After Radical Prostatectomy in North American High-Risk Prostate Cancer Patients",
abstract = "PURPOSE: To investigate pathological stage at radical prostatectomy (RP) using the {"}Partin tables{"} approach in NCCN high-risk (HR) prostate cancer (PCa) patients.MATERIALS AND METHODS: Within the SEER 2010 to 2016 database, we identified 7,718 NCCN HR PCa patients. Cross-tabulation was used to illustrate the distribution of organ confined disease (OC, pT2), extra-prostatic extension (EPE, pT3a), seminal vesicles invasion (SVI, pT3b), lymph node invasion (LNI, pT2N1), extra-prostatic and lymph node invasion (EPE + LNI, pT3aN1), and seminal vescicale and lymph node invasion (SVI + LNI, pT3bN1), according to preoperative criteria, which consisted in PSA, clinical T stage, biopsy Gleason Score (GS). Binomial 95%CI was constructed for the reported proportions.RESULTS: Median (IQR) PSA levels was 9 (6-20) ng/ml. The majority of patient harbored cT1c (51%) followed by cT2 (35%) and cT3 (14%) stage. Most patients exhibited GS 4+4 (43%). Overall, 87 vs. 15 vs. 2% of patients harbored only 1 vs. 2 vs. all 3 HR criteria. At RP, OC, EPE, SVI, and LNI rates were respectively 36%, 27%, 17%, and 19%. Highest levels of OC were recorded for cT1c, PSA <10 ng/mL and biopsy GS4+4. Conversely, EPE, SVI and LNI were the highest in patients with cT3, PSA ≥20 ng/mL and GS 5+5. After stratification according to clinical stages, OC rates decreased with increasing PSA levels and GS. Conversely, EPE, SVI and LNI rates increased with increasing PSA and GS.CONCLUSION: We provide a lookup table to illustrate the relationship between clinical and pathological characteristics in NCCN HR PCa patients.",
keywords = "Humans, Male, Neoplasm Staging, North America, Prostate-Specific Antigen, Prostatectomy, Prostatic Neoplasms/pathology, Seminal Vesicles/pathology",
author = "Francesco Chierigo and Marco Borghesi and Christoph W{\"u}rnschimmel and Flammia, {Rocco Simone} and Gabriele Sorce and Benedikt Hoeh and Lukas Hohenhorst and Zhe Tian and Fred Saad and Derya Tilki and Michele Gallucci and Alberto Briganti and Francesco Montorsi and Chun, {Felix K H} and Shariat, {Shahrokh F} and Guglielmo Mantica and Nazareno Suardi and Carlo Terrone and Karakiewicz, {Pierre I}",
note = "Copyright {\textcopyright} 2022 Elsevier Inc. All rights reserved.",
year = "2022",
month = oct,
doi = "10.1016/j.clgc.2022.04.005",
language = "English",
volume = "20",
pages = "e380--e389",
journal = "CLIN GENITOURIN CANC",
issn = "1558-7673",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Contemporary Pathological Stage Distribution After Radical Prostatectomy in North American High-Risk Prostate Cancer Patients

AU - Chierigo, Francesco

AU - Borghesi, Marco

AU - Würnschimmel, Christoph

AU - Flammia, Rocco Simone

AU - Sorce, Gabriele

AU - Hoeh, Benedikt

AU - Hohenhorst, Lukas

AU - Tian, Zhe

AU - Saad, Fred

AU - Tilki, Derya

AU - Gallucci, Michele

AU - Briganti, Alberto

AU - Montorsi, Francesco

AU - Chun, Felix K H

AU - Shariat, Shahrokh F

AU - Mantica, Guglielmo

AU - Suardi, Nazareno

AU - Terrone, Carlo

AU - Karakiewicz, Pierre I

N1 - Copyright © 2022 Elsevier Inc. All rights reserved.

PY - 2022/10

Y1 - 2022/10

N2 - PURPOSE: To investigate pathological stage at radical prostatectomy (RP) using the "Partin tables" approach in NCCN high-risk (HR) prostate cancer (PCa) patients.MATERIALS AND METHODS: Within the SEER 2010 to 2016 database, we identified 7,718 NCCN HR PCa patients. Cross-tabulation was used to illustrate the distribution of organ confined disease (OC, pT2), extra-prostatic extension (EPE, pT3a), seminal vesicles invasion (SVI, pT3b), lymph node invasion (LNI, pT2N1), extra-prostatic and lymph node invasion (EPE + LNI, pT3aN1), and seminal vescicale and lymph node invasion (SVI + LNI, pT3bN1), according to preoperative criteria, which consisted in PSA, clinical T stage, biopsy Gleason Score (GS). Binomial 95%CI was constructed for the reported proportions.RESULTS: Median (IQR) PSA levels was 9 (6-20) ng/ml. The majority of patient harbored cT1c (51%) followed by cT2 (35%) and cT3 (14%) stage. Most patients exhibited GS 4+4 (43%). Overall, 87 vs. 15 vs. 2% of patients harbored only 1 vs. 2 vs. all 3 HR criteria. At RP, OC, EPE, SVI, and LNI rates were respectively 36%, 27%, 17%, and 19%. Highest levels of OC were recorded for cT1c, PSA <10 ng/mL and biopsy GS4+4. Conversely, EPE, SVI and LNI were the highest in patients with cT3, PSA ≥20 ng/mL and GS 5+5. After stratification according to clinical stages, OC rates decreased with increasing PSA levels and GS. Conversely, EPE, SVI and LNI rates increased with increasing PSA and GS.CONCLUSION: We provide a lookup table to illustrate the relationship between clinical and pathological characteristics in NCCN HR PCa patients.

AB - PURPOSE: To investigate pathological stage at radical prostatectomy (RP) using the "Partin tables" approach in NCCN high-risk (HR) prostate cancer (PCa) patients.MATERIALS AND METHODS: Within the SEER 2010 to 2016 database, we identified 7,718 NCCN HR PCa patients. Cross-tabulation was used to illustrate the distribution of organ confined disease (OC, pT2), extra-prostatic extension (EPE, pT3a), seminal vesicles invasion (SVI, pT3b), lymph node invasion (LNI, pT2N1), extra-prostatic and lymph node invasion (EPE + LNI, pT3aN1), and seminal vescicale and lymph node invasion (SVI + LNI, pT3bN1), according to preoperative criteria, which consisted in PSA, clinical T stage, biopsy Gleason Score (GS). Binomial 95%CI was constructed for the reported proportions.RESULTS: Median (IQR) PSA levels was 9 (6-20) ng/ml. The majority of patient harbored cT1c (51%) followed by cT2 (35%) and cT3 (14%) stage. Most patients exhibited GS 4+4 (43%). Overall, 87 vs. 15 vs. 2% of patients harbored only 1 vs. 2 vs. all 3 HR criteria. At RP, OC, EPE, SVI, and LNI rates were respectively 36%, 27%, 17%, and 19%. Highest levels of OC were recorded for cT1c, PSA <10 ng/mL and biopsy GS4+4. Conversely, EPE, SVI and LNI were the highest in patients with cT3, PSA ≥20 ng/mL and GS 5+5. After stratification according to clinical stages, OC rates decreased with increasing PSA levels and GS. Conversely, EPE, SVI and LNI rates increased with increasing PSA and GS.CONCLUSION: We provide a lookup table to illustrate the relationship between clinical and pathological characteristics in NCCN HR PCa patients.

KW - Humans

KW - Male

KW - Neoplasm Staging

KW - North America

KW - Prostate-Specific Antigen

KW - Prostatectomy

KW - Prostatic Neoplasms/pathology

KW - Seminal Vesicles/pathology

U2 - 10.1016/j.clgc.2022.04.005

DO - 10.1016/j.clgc.2022.04.005

M3 - SCORING: Journal article

C2 - 35618597

VL - 20

SP - e380-e389

JO - CLIN GENITOURIN CANC

JF - CLIN GENITOURIN CANC

SN - 1558-7673

IS - 5

ER -