Contemporary conditional cancer-specific survival rates in surgically treated adrenocortical carcinoma patients: A stage-specific analysis
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Contemporary conditional cancer-specific survival rates in surgically treated adrenocortical carcinoma patients: A stage-specific analysis. / Panunzio, Andrea; Barletta, Francesco; Tappero, Stefano; Cano Garcia, Cristina; Piccinelli, Mattia; Incesu, Reha-Baris; Law, Kyle W; Tian, Zhe; Tafuri, Alessandro; Tilki, Derya; De Cobelli, Ottavio; Chun, Felix K H; Terrone, Carlo; Briganti, Alberto; Saad, Fred; Shariat, Shahrokh F; Bourdeau, Isabelle; Cerruto, Maria A; Antonelli, Alessandro; Karakiewicz, Pierre I.
in: J SURG ONCOL, Jahrgang 127, Nr. 4, 03.2023, S. 560-567.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Contemporary conditional cancer-specific survival rates in surgically treated adrenocortical carcinoma patients: A stage-specific analysis
AU - Panunzio, Andrea
AU - Barletta, Francesco
AU - Tappero, Stefano
AU - Cano Garcia, Cristina
AU - Piccinelli, Mattia
AU - Incesu, Reha-Baris
AU - Law, Kyle W
AU - Tian, Zhe
AU - Tafuri, Alessandro
AU - Tilki, Derya
AU - De Cobelli, Ottavio
AU - Chun, Felix K H
AU - Terrone, Carlo
AU - Briganti, Alberto
AU - Saad, Fred
AU - Shariat, Shahrokh F
AU - Bourdeau, Isabelle
AU - Cerruto, Maria A
AU - Antonelli, Alessandro
AU - Karakiewicz, Pierre I
N1 - © 2022 Wiley Periodicals LLC.
PY - 2023/3
Y1 - 2023/3
N2 - BACKGROUND AND OBJECTIVES: We examined the effect of disease-free interval (DFI) duration on cancer-specific mortality (CSM)-free survival, otherwise known as the effect of conditional survival, in surgically treated adrenocortical carcinoma (ACC) patients.METHODS: Within the Surveillance, Epidemiology, and End Results database (2004-2018), 867 ACC patients treated with adrenalectomy were identified. Conditional survival estimates at 5-years were assessed based on DFI duration and according to stage at presentation. Separate Cox regression models were fitted at baseline and according to DFI.RESULTS: Overall, 406 (47%), 285 (33%), and 176 (20%) patients were stage I-II, III and IV, respectively. In conditional survival analysis, providing a DFI of 24 months, 5-year CSM-free survival at initial diagnosis increased from 66% to 80% in stage I-II, from 35% to 66% in stage III, and from 14% to 36% in stage IV. In multivariable Cox regression models, stage III (hazard ratio [HR]: 2.38; p < 0.001) and IV (HR: 4.67; p < 0.001) independently predicted higher CSM, relative to stage I-II. The magnitude of this effect decreased over time, providing increasing DFI duration.CONCLUSIONS: In surgically treated ACC, survival probabilities increase with longer DFI duration. This improvement is more pronounced in stage III, followed by stages IV and I-II patients, in that order. Survival estimates accounting for DFI may prove valuable in patients counseling.
AB - BACKGROUND AND OBJECTIVES: We examined the effect of disease-free interval (DFI) duration on cancer-specific mortality (CSM)-free survival, otherwise known as the effect of conditional survival, in surgically treated adrenocortical carcinoma (ACC) patients.METHODS: Within the Surveillance, Epidemiology, and End Results database (2004-2018), 867 ACC patients treated with adrenalectomy were identified. Conditional survival estimates at 5-years were assessed based on DFI duration and according to stage at presentation. Separate Cox regression models were fitted at baseline and according to DFI.RESULTS: Overall, 406 (47%), 285 (33%), and 176 (20%) patients were stage I-II, III and IV, respectively. In conditional survival analysis, providing a DFI of 24 months, 5-year CSM-free survival at initial diagnosis increased from 66% to 80% in stage I-II, from 35% to 66% in stage III, and from 14% to 36% in stage IV. In multivariable Cox regression models, stage III (hazard ratio [HR]: 2.38; p < 0.001) and IV (HR: 4.67; p < 0.001) independently predicted higher CSM, relative to stage I-II. The magnitude of this effect decreased over time, providing increasing DFI duration.CONCLUSIONS: In surgically treated ACC, survival probabilities increase with longer DFI duration. This improvement is more pronounced in stage III, followed by stages IV and I-II patients, in that order. Survival estimates accounting for DFI may prove valuable in patients counseling.
KW - Humans
KW - Adrenocortical Carcinoma/surgery
KW - Survival Rate
KW - Neoplasm Staging
KW - Survival Analysis
KW - Adrenal Cortex Neoplasms/surgery
U2 - 10.1002/jso.27161
DO - 10.1002/jso.27161
M3 - SCORING: Journal article
C2 - 36434748
VL - 127
SP - 560
EP - 567
JO - J SURG ONCOL
JF - J SURG ONCOL
SN - 0022-4790
IS - 4
ER -