Consolidation of Tumorous Mandibular Ramus Defect During Denosumab Treatment for Rapidly Progressive Metastatic Breast Cancer
Beteiligte Einrichtungen
Abstract
BACKGROUND: Pharmacological inhibition of osteoclast activity is an essential component of oncological therapy for patients with bone metastases. In rare cases, medication-related osteonecrosis of the jaws (MRONJ) is observed. MRONJ can cause bone defects not inferior to primary or metastatic jaw neoplasms. Oral examination of patients on osteoclast-inhibiting medication aims to identify risk factors at an early stage and to initiate therapy. The current focus on osteoclast-inhibiting drugs in the maxillofacial region is MRONJ. Effects of the substances other than MRONJ are rarely reported.
CASE REPORT: The female patient with metastatic breast cancer had developed extensive osteolysis of the mandibular ramus at the time of initial diagnosis. The patient was treated with denosumab. Seven months later, a significant reduction in the mandibular osteolytic zone was recorded. However, known bone metastases from other sites had increased in size during multimodal therapy, and further metastases were recorded.
CONCLUSION: Jaw metastasis can shrink under denosumab therapy.
Bibliografische Daten
Originalsprache | Englisch |
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ISSN | 0250-7005 |
DOIs | |
Status | Veröffentlicht - 10.2021 |
Anmerkungen des Dekanats
Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
PubMed | 34593458 |
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