Consensus of German transplant centers on hematopoietic stem cell transplantation in Fanconi anemia
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Consensus of German transplant centers on hematopoietic stem cell transplantation in Fanconi anemia. / Chao, M M; Ebell, W; Bader, P; Beier, R; Burkhardt, B; Feuchtinger, T; Handgretinger, R; Hanenberg, H; Koehl, U; Kratz, C; Kremens, B; Lang, P; Meisel, R; Müller, Ingo; Roessig, C; Sauer, M; Schlegel, P G; Schulz, A; Strahm, B; Thol, F; Sykora, K W.
in: KLIN PADIATR, Jahrgang 227, Nr. 3, 05.2015, S. 157-65.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Consensus of German transplant centers on hematopoietic stem cell transplantation in Fanconi anemia
AU - Chao, M M
AU - Ebell, W
AU - Bader, P
AU - Beier, R
AU - Burkhardt, B
AU - Feuchtinger, T
AU - Handgretinger, R
AU - Hanenberg, H
AU - Koehl, U
AU - Kratz, C
AU - Kremens, B
AU - Lang, P
AU - Meisel, R
AU - Müller, Ingo
AU - Roessig, C
AU - Sauer, M
AU - Schlegel, P G
AU - Schulz, A
AU - Strahm, B
AU - Thol, F
AU - Sykora, K W
N1 - © Georg Thieme Verlag KG Stuttgart · New York.
PY - 2015/5
Y1 - 2015/5
N2 - Allogeneic hematopoietic stem cell transplantation (HSCT) is currently the only curative therapy for the severe hematopoietic complications associated with Fanconi anemia (FA). In Germany, it is estimated that 10-15 transplants are performed annually for FA. However, because FA is a DNA repair disorder, standard conditioning regimens confer a high risk of excessive regimen-related toxicities and mortality, and reduced intensity regimens are linked with graft failure in some FA patients. Moreover, development of graft-versus-host disease is a major contributing factor for secondary solid tumors. The relative rarity of the disorder limits HSCT experience at any single center. Consensus meetings were convened to develop a national approach for HSCT in FA. This manuscript outlines current experience and knowledge about HSCT in FA and, based on this analysis, general recommendations reached at these meetings.
AB - Allogeneic hematopoietic stem cell transplantation (HSCT) is currently the only curative therapy for the severe hematopoietic complications associated with Fanconi anemia (FA). In Germany, it is estimated that 10-15 transplants are performed annually for FA. However, because FA is a DNA repair disorder, standard conditioning regimens confer a high risk of excessive regimen-related toxicities and mortality, and reduced intensity regimens are linked with graft failure in some FA patients. Moreover, development of graft-versus-host disease is a major contributing factor for secondary solid tumors. The relative rarity of the disorder limits HSCT experience at any single center. Consensus meetings were convened to develop a national approach for HSCT in FA. This manuscript outlines current experience and knowledge about HSCT in FA and, based on this analysis, general recommendations reached at these meetings.
U2 - 10.1055/s-0035-1548841
DO - 10.1055/s-0035-1548841
M3 - SCORING: Journal article
C2 - 25985449
VL - 227
SP - 157
EP - 165
JO - KLIN PADIATR
JF - KLIN PADIATR
SN - 0300-8630
IS - 3
ER -