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Conditional survival after radical cystectomy for non-metastatic muscle-invasive squamous cell carcinoma of the urinary bladder: A population-based analysis

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Conditional survival after radical cystectomy for non-metastatic muscle-invasive squamous cell carcinoma of the urinary bladder: A population-based analysis. / Barletta, Francesco; Tappero, Stefano; Panunzio, Andrea; Incesu, Reha-Baris; Cano Garcia, Cristina; Piccinelli, Mattia Luca; Tian, Zhe; Gandaglia, Giorgio; Moschini, Marco; Terrone, Carlo; Antonelli, Alessandro; Tilki, Derya; Chun, Felix K H; De Cobelli, Ottavio; Saad, Fred; Shariat, Shahrokh F; Montorsi, Francesco; Briganti, Alberto; Karakiewicz, Pierre I.

in: UROL ONCOL-SEMIN ORI, Jahrgang 41, Nr. 3, 03.2023, S. 147.e1-147.e6.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Barletta, F, Tappero, S, Panunzio, A, Incesu, R-B, Cano Garcia, C, Piccinelli, ML, Tian, Z, Gandaglia, G, Moschini, M, Terrone, C, Antonelli, A, Tilki, D, Chun, FKH, De Cobelli, O, Saad, F, Shariat, SF, Montorsi, F, Briganti, A & Karakiewicz, PI 2023, 'Conditional survival after radical cystectomy for non-metastatic muscle-invasive squamous cell carcinoma of the urinary bladder: A population-based analysis', UROL ONCOL-SEMIN ORI, Jg. 41, Nr. 3, S. 147.e1-147.e6. https://doi.org/10.1016/j.urolonc.2022.10.027

APA

Barletta, F., Tappero, S., Panunzio, A., Incesu, R-B., Cano Garcia, C., Piccinelli, M. L., Tian, Z., Gandaglia, G., Moschini, M., Terrone, C., Antonelli, A., Tilki, D., Chun, F. K. H., De Cobelli, O., Saad, F., Shariat, S. F., Montorsi, F., Briganti, A., & Karakiewicz, P. I. (2023). Conditional survival after radical cystectomy for non-metastatic muscle-invasive squamous cell carcinoma of the urinary bladder: A population-based analysis. UROL ONCOL-SEMIN ORI, 41(3), 147.e1-147.e6. https://doi.org/10.1016/j.urolonc.2022.10.027

Vancouver

Barletta F, Tappero S, Panunzio A, Incesu R-B, Cano Garcia C, Piccinelli ML et al. Conditional survival after radical cystectomy for non-metastatic muscle-invasive squamous cell carcinoma of the urinary bladder: A population-based analysis. UROL ONCOL-SEMIN ORI. 2023 Mär;41(3):147.e1-147.e6. https://doi.org/10.1016/j.urolonc.2022.10.027

Bibtex

@article{d66cdee660414aad9c2e96fbe99cff1d,
title = "Conditional survival after radical cystectomy for non-metastatic muscle-invasive squamous cell carcinoma of the urinary bladder: A population-based analysis",
abstract = "PURPOSE: To assess the effect of event-free survival duration on cancer-specific mortality (CSM) after radical cystectomy (RC) in nonmetastatic muscle-invasive squamous cell carcinoma of the urinary bladder.METHODS: RC patients treated for non-metastatic muscle-invasive squamous cell carcinoma of the urinary bladder were identified within the Surveillance, Epidemiology, and End Results database (2000-2018). Independent predictor status for CSM of T and N stage groupings (i.e., T2N0, T3N0, T4N0, and TanyN1-3) was tested in multivariable Cox-regression models. Conditional 5-year CSM-free estimates were assessed at baseline and at 4 specific event-free survival times (i.e. 6, 12, 18 and 24 months), within each of the 4 examined stage groups.RESULTS: Of 981 RC patients, 206 (21%), 416 (42%), 152 (16%), and 207 (21%) were T2N0, T3N0, T4N0, and TanyN1-3, respectively. In multivariable Cox-regression models T3N0 (HR 1.94), T4N0 (HR 5.22), and TanyN1-3 (HR 6.62) were independent predictors of CSM, relative to T2N0. In conditional survival analyses based on 24 months event-free status, survival estimates were: 89% for T2N0 vs. 76% at baseline (Δ = 13%), 84% for T3N0 vs. 58% at baseline (Δ = 26%), 69% for T4N0 vs. 25% at baseline (Δ = 44%), 69% for TanyN1-3 vs. 22% at baseline (Δ = 47%).CONCLUSIONS: Event-free status at 24 months of follow-up is associated with substantially higher CSM-free survival than when CSM-free survival is predicted at baseline. The magnitude of this effect is most pronounced in TanyN1-3 and T4N0 patients, intermediate in T3N0 and more modest, nonetheless important, in T2N0.",
author = "Francesco Barletta and Stefano Tappero and Andrea Panunzio and Reha-Baris Incesu and {Cano Garcia}, Cristina and Piccinelli, {Mattia Luca} and Zhe Tian and Giorgio Gandaglia and Marco Moschini and Carlo Terrone and Alessandro Antonelli and Derya Tilki and Chun, {Felix K H} and {De Cobelli}, Ottavio and Fred Saad and Shariat, {Shahrokh F} and Francesco Montorsi and Alberto Briganti and Karakiewicz, {Pierre I}",
note = "Copyright {\textcopyright} 2022 Elsevier Inc. All rights reserved.",
year = "2023",
month = mar,
doi = "10.1016/j.urolonc.2022.10.027",
language = "English",
volume = "41",
pages = "147.e1--147.e6",
journal = "UROL ONCOL-SEMIN ORI",
issn = "1078-1439",
publisher = "Elsevier Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Conditional survival after radical cystectomy for non-metastatic muscle-invasive squamous cell carcinoma of the urinary bladder: A population-based analysis

AU - Barletta, Francesco

AU - Tappero, Stefano

AU - Panunzio, Andrea

AU - Incesu, Reha-Baris

AU - Cano Garcia, Cristina

AU - Piccinelli, Mattia Luca

AU - Tian, Zhe

AU - Gandaglia, Giorgio

AU - Moschini, Marco

AU - Terrone, Carlo

AU - Antonelli, Alessandro

AU - Tilki, Derya

AU - Chun, Felix K H

AU - De Cobelli, Ottavio

AU - Saad, Fred

AU - Shariat, Shahrokh F

AU - Montorsi, Francesco

AU - Briganti, Alberto

AU - Karakiewicz, Pierre I

N1 - Copyright © 2022 Elsevier Inc. All rights reserved.

PY - 2023/3

Y1 - 2023/3

N2 - PURPOSE: To assess the effect of event-free survival duration on cancer-specific mortality (CSM) after radical cystectomy (RC) in nonmetastatic muscle-invasive squamous cell carcinoma of the urinary bladder.METHODS: RC patients treated for non-metastatic muscle-invasive squamous cell carcinoma of the urinary bladder were identified within the Surveillance, Epidemiology, and End Results database (2000-2018). Independent predictor status for CSM of T and N stage groupings (i.e., T2N0, T3N0, T4N0, and TanyN1-3) was tested in multivariable Cox-regression models. Conditional 5-year CSM-free estimates were assessed at baseline and at 4 specific event-free survival times (i.e. 6, 12, 18 and 24 months), within each of the 4 examined stage groups.RESULTS: Of 981 RC patients, 206 (21%), 416 (42%), 152 (16%), and 207 (21%) were T2N0, T3N0, T4N0, and TanyN1-3, respectively. In multivariable Cox-regression models T3N0 (HR 1.94), T4N0 (HR 5.22), and TanyN1-3 (HR 6.62) were independent predictors of CSM, relative to T2N0. In conditional survival analyses based on 24 months event-free status, survival estimates were: 89% for T2N0 vs. 76% at baseline (Δ = 13%), 84% for T3N0 vs. 58% at baseline (Δ = 26%), 69% for T4N0 vs. 25% at baseline (Δ = 44%), 69% for TanyN1-3 vs. 22% at baseline (Δ = 47%).CONCLUSIONS: Event-free status at 24 months of follow-up is associated with substantially higher CSM-free survival than when CSM-free survival is predicted at baseline. The magnitude of this effect is most pronounced in TanyN1-3 and T4N0 patients, intermediate in T3N0 and more modest, nonetheless important, in T2N0.

AB - PURPOSE: To assess the effect of event-free survival duration on cancer-specific mortality (CSM) after radical cystectomy (RC) in nonmetastatic muscle-invasive squamous cell carcinoma of the urinary bladder.METHODS: RC patients treated for non-metastatic muscle-invasive squamous cell carcinoma of the urinary bladder were identified within the Surveillance, Epidemiology, and End Results database (2000-2018). Independent predictor status for CSM of T and N stage groupings (i.e., T2N0, T3N0, T4N0, and TanyN1-3) was tested in multivariable Cox-regression models. Conditional 5-year CSM-free estimates were assessed at baseline and at 4 specific event-free survival times (i.e. 6, 12, 18 and 24 months), within each of the 4 examined stage groups.RESULTS: Of 981 RC patients, 206 (21%), 416 (42%), 152 (16%), and 207 (21%) were T2N0, T3N0, T4N0, and TanyN1-3, respectively. In multivariable Cox-regression models T3N0 (HR 1.94), T4N0 (HR 5.22), and TanyN1-3 (HR 6.62) were independent predictors of CSM, relative to T2N0. In conditional survival analyses based on 24 months event-free status, survival estimates were: 89% for T2N0 vs. 76% at baseline (Δ = 13%), 84% for T3N0 vs. 58% at baseline (Δ = 26%), 69% for T4N0 vs. 25% at baseline (Δ = 44%), 69% for TanyN1-3 vs. 22% at baseline (Δ = 47%).CONCLUSIONS: Event-free status at 24 months of follow-up is associated with substantially higher CSM-free survival than when CSM-free survival is predicted at baseline. The magnitude of this effect is most pronounced in TanyN1-3 and T4N0 patients, intermediate in T3N0 and more modest, nonetheless important, in T2N0.

U2 - 10.1016/j.urolonc.2022.10.027

DO - 10.1016/j.urolonc.2022.10.027

M3 - SCORING: Journal article

C2 - 36428165

VL - 41

SP - 147.e1-147.e6

JO - UROL ONCOL-SEMIN ORI

JF - UROL ONCOL-SEMIN ORI

SN - 1078-1439

IS - 3

ER -