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Complication rate after cystectomy following pelvic radiotherapy: an international, multicenter, retrospective series of 682 cases

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Complication rate after cystectomy following pelvic radiotherapy: an international, multicenter, retrospective series of 682 cases. / Gontero, Paolo; Pisano, Francesca; Palou, Joan; Joniau, Steven; Albersen, Maarten; Colombo, Renzo; Briganti, Alberto; Pellucchi, Federico; Faba, Oscar Rodriguez; van Rhijn, Bas W; van de Putte, Elies Fransen; Babjuk, Marko; Fritsche, Hanz Martin; Mayr, Roman; Albers, Peter; Niegisch, Gunter; Anract, Julien; Masson-Lecomte, Alexandra; De la Taille, Alexandre; Roupret, Morgan; Peyronnet, Benoit; Cai, Tomaso; Witjes, Alfred J; Bruins, Max; Baniel, Jack; Mano, Roy; Lapini, Alberto; Sessa, Francesco; Irani, Jaques; Brausi, Maurizio; Stenzl, Arnulf; Karnes, Jeffrey R; Scherr, Douglas; O'Malley, Padraic; Taylor, Benjamin; Shariat, Shahrokh F; Black, Peter; Abdi, Hamidreza; Matveev, Vsevolod B; Samuseva, Olga; Parekh, Dipen; Gonzalgo, Mark; Vetterlein, Malte W; Aziz, Atiqullah; Fisch, Margit; Catto, James; Pang, Karl H; Xylinas, Evanguelos; Rink, Michael; Young Academic Urologists Urothelial Carcinoma Group of the European Association of Urology.

in: WORLD J UROL, Jahrgang 38, Nr. 8, 08.2020, S. 1959-1968.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gontero, P, Pisano, F, Palou, J, Joniau, S, Albersen, M, Colombo, R, Briganti, A, Pellucchi, F, Faba, OR, van Rhijn, BW, van de Putte, EF, Babjuk, M, Fritsche, HM, Mayr, R, Albers, P, Niegisch, G, Anract, J, Masson-Lecomte, A, De la Taille, A, Roupret, M, Peyronnet, B, Cai, T, Witjes, AJ, Bruins, M, Baniel, J, Mano, R, Lapini, A, Sessa, F, Irani, J, Brausi, M, Stenzl, A, Karnes, JR, Scherr, D, O'Malley, P, Taylor, B, Shariat, SF, Black, P, Abdi, H, Matveev, VB, Samuseva, O, Parekh, D, Gonzalgo, M, Vetterlein, MW, Aziz, A, Fisch, M, Catto, J, Pang, KH, Xylinas, E, Rink, M & Young Academic Urologists Urothelial Carcinoma Group of the European Association of Urology 2020, 'Complication rate after cystectomy following pelvic radiotherapy: an international, multicenter, retrospective series of 682 cases', WORLD J UROL, Jg. 38, Nr. 8, S. 1959-1968. https://doi.org/10.1007/s00345-019-02982-6

APA

Gontero, P., Pisano, F., Palou, J., Joniau, S., Albersen, M., Colombo, R., Briganti, A., Pellucchi, F., Faba, O. R., van Rhijn, B. W., van de Putte, E. F., Babjuk, M., Fritsche, H. M., Mayr, R., Albers, P., Niegisch, G., Anract, J., Masson-Lecomte, A., De la Taille, A., ... Young Academic Urologists Urothelial Carcinoma Group of the European Association of Urology (2020). Complication rate after cystectomy following pelvic radiotherapy: an international, multicenter, retrospective series of 682 cases. WORLD J UROL, 38(8), 1959-1968. https://doi.org/10.1007/s00345-019-02982-6

Vancouver

Gontero P, Pisano F, Palou J, Joniau S, Albersen M, Colombo R et al. Complication rate after cystectomy following pelvic radiotherapy: an international, multicenter, retrospective series of 682 cases. WORLD J UROL. 2020 Aug;38(8):1959-1968. https://doi.org/10.1007/s00345-019-02982-6

Bibtex

@article{e0760bbe27dd4e52b5fd20da2b516a9e,
title = "Complication rate after cystectomy following pelvic radiotherapy: an international, multicenter, retrospective series of 682 cases",
abstract = "PURPOSE: Conflicting evidence exists on the complication rates after cystectomy following previous radiation (pRTC) with only a few available series. We aim to assess the complication rate of pRTC for abdominal-pelvic malignancies.METHODS: Patients treated with radical cystectomy following any previous history of RT and with available information on complications for a minimum of 1 year were included. Univariable and multivariable logistic regression models were used to assess the relationship between the variable parameters and the risk of any complication.RESULTS: 682 patients underwent pRTC after a previous RT (80.5% EBRT) for prostate, bladder (BC), gynecological or other cancers in 49.1%, 27.4%, 9.8% and 12.9%, respectively. Overall, 512 (75.1%) had at least one post-surgical complication, classified as Clavien ≥ 3 in 29.6% and Clavien V in 2.9%. At least one surgical complication occurred in 350 (51.3%), including bowel leakage in 6.2% and ureteric stricture in 9.4%. A medical complication was observed in 359 (52.6%) patients, with UTI/pyelonephritis being the most common (19%), followed by renal failure (12%). The majority of patients (86%) received an incontinent urinary diversion. In multivariable analysis adjusted for age, gender and type of RT, patients treated with RT for bladder cancer had a 1.7 times increased relative risk of experiencing any complication after RC compared to those with RT for prostate cancer (p = 0.023). The type of diversion (continent vs non-continent) did not influence the risk of complications.CONCLUSION: pRTC carries a high rate of major complications that dramatically exceeds the rates reported in RT-na{\"i}ve RCs.",
author = "Paolo Gontero and Francesca Pisano and Joan Palou and Steven Joniau and Maarten Albersen and Renzo Colombo and Alberto Briganti and Federico Pellucchi and Faba, {Oscar Rodriguez} and {van Rhijn}, {Bas W} and {van de Putte}, {Elies Fransen} and Marko Babjuk and Fritsche, {Hanz Martin} and Roman Mayr and Peter Albers and Gunter Niegisch and Julien Anract and Alexandra Masson-Lecomte and {De la Taille}, Alexandre and Morgan Roupret and Benoit Peyronnet and Tomaso Cai and Witjes, {Alfred J} and Max Bruins and Jack Baniel and Roy Mano and Alberto Lapini and Francesco Sessa and Jaques Irani and Maurizio Brausi and Arnulf Stenzl and Karnes, {Jeffrey R} and Douglas Scherr and Padraic O'Malley and Benjamin Taylor and Shariat, {Shahrokh F} and Peter Black and Hamidreza Abdi and Matveev, {Vsevolod B} and Olga Samuseva and Dipen Parekh and Mark Gonzalgo and Vetterlein, {Malte W} and Atiqullah Aziz and Margit Fisch and James Catto and Pang, {Karl H} and Evanguelos Xylinas and Michael Rink and {Young Academic Urologists Urothelial Carcinoma Group of the European Association of Urology}",
year = "2020",
month = aug,
doi = "10.1007/s00345-019-02982-6",
language = "English",
volume = "38",
pages = "1959--1968",
journal = "WORLD J UROL",
issn = "0724-4983",
publisher = "Springer",
number = "8",

}

RIS

TY - JOUR

T1 - Complication rate after cystectomy following pelvic radiotherapy: an international, multicenter, retrospective series of 682 cases

AU - Gontero, Paolo

AU - Pisano, Francesca

AU - Palou, Joan

AU - Joniau, Steven

AU - Albersen, Maarten

AU - Colombo, Renzo

AU - Briganti, Alberto

AU - Pellucchi, Federico

AU - Faba, Oscar Rodriguez

AU - van Rhijn, Bas W

AU - van de Putte, Elies Fransen

AU - Babjuk, Marko

AU - Fritsche, Hanz Martin

AU - Mayr, Roman

AU - Albers, Peter

AU - Niegisch, Gunter

AU - Anract, Julien

AU - Masson-Lecomte, Alexandra

AU - De la Taille, Alexandre

AU - Roupret, Morgan

AU - Peyronnet, Benoit

AU - Cai, Tomaso

AU - Witjes, Alfred J

AU - Bruins, Max

AU - Baniel, Jack

AU - Mano, Roy

AU - Lapini, Alberto

AU - Sessa, Francesco

AU - Irani, Jaques

AU - Brausi, Maurizio

AU - Stenzl, Arnulf

AU - Karnes, Jeffrey R

AU - Scherr, Douglas

AU - O'Malley, Padraic

AU - Taylor, Benjamin

AU - Shariat, Shahrokh F

AU - Black, Peter

AU - Abdi, Hamidreza

AU - Matveev, Vsevolod B

AU - Samuseva, Olga

AU - Parekh, Dipen

AU - Gonzalgo, Mark

AU - Vetterlein, Malte W

AU - Aziz, Atiqullah

AU - Fisch, Margit

AU - Catto, James

AU - Pang, Karl H

AU - Xylinas, Evanguelos

AU - Rink, Michael

AU - Young Academic Urologists Urothelial Carcinoma Group of the European Association of Urology

PY - 2020/8

Y1 - 2020/8

N2 - PURPOSE: Conflicting evidence exists on the complication rates after cystectomy following previous radiation (pRTC) with only a few available series. We aim to assess the complication rate of pRTC for abdominal-pelvic malignancies.METHODS: Patients treated with radical cystectomy following any previous history of RT and with available information on complications for a minimum of 1 year were included. Univariable and multivariable logistic regression models were used to assess the relationship between the variable parameters and the risk of any complication.RESULTS: 682 patients underwent pRTC after a previous RT (80.5% EBRT) for prostate, bladder (BC), gynecological or other cancers in 49.1%, 27.4%, 9.8% and 12.9%, respectively. Overall, 512 (75.1%) had at least one post-surgical complication, classified as Clavien ≥ 3 in 29.6% and Clavien V in 2.9%. At least one surgical complication occurred in 350 (51.3%), including bowel leakage in 6.2% and ureteric stricture in 9.4%. A medical complication was observed in 359 (52.6%) patients, with UTI/pyelonephritis being the most common (19%), followed by renal failure (12%). The majority of patients (86%) received an incontinent urinary diversion. In multivariable analysis adjusted for age, gender and type of RT, patients treated with RT for bladder cancer had a 1.7 times increased relative risk of experiencing any complication after RC compared to those with RT for prostate cancer (p = 0.023). The type of diversion (continent vs non-continent) did not influence the risk of complications.CONCLUSION: pRTC carries a high rate of major complications that dramatically exceeds the rates reported in RT-naïve RCs.

AB - PURPOSE: Conflicting evidence exists on the complication rates after cystectomy following previous radiation (pRTC) with only a few available series. We aim to assess the complication rate of pRTC for abdominal-pelvic malignancies.METHODS: Patients treated with radical cystectomy following any previous history of RT and with available information on complications for a minimum of 1 year were included. Univariable and multivariable logistic regression models were used to assess the relationship between the variable parameters and the risk of any complication.RESULTS: 682 patients underwent pRTC after a previous RT (80.5% EBRT) for prostate, bladder (BC), gynecological or other cancers in 49.1%, 27.4%, 9.8% and 12.9%, respectively. Overall, 512 (75.1%) had at least one post-surgical complication, classified as Clavien ≥ 3 in 29.6% and Clavien V in 2.9%. At least one surgical complication occurred in 350 (51.3%), including bowel leakage in 6.2% and ureteric stricture in 9.4%. A medical complication was observed in 359 (52.6%) patients, with UTI/pyelonephritis being the most common (19%), followed by renal failure (12%). The majority of patients (86%) received an incontinent urinary diversion. In multivariable analysis adjusted for age, gender and type of RT, patients treated with RT for bladder cancer had a 1.7 times increased relative risk of experiencing any complication after RC compared to those with RT for prostate cancer (p = 0.023). The type of diversion (continent vs non-continent) did not influence the risk of complications.CONCLUSION: pRTC carries a high rate of major complications that dramatically exceeds the rates reported in RT-naïve RCs.

U2 - 10.1007/s00345-019-02982-6

DO - 10.1007/s00345-019-02982-6

M3 - SCORING: Journal article

C2 - 31691084

VL - 38

SP - 1959

EP - 1968

JO - WORLD J UROL

JF - WORLD J UROL

SN - 0724-4983

IS - 8

ER -