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Complete Revascularization Versus Culprit Lesion Only in Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease: A DANAMI-3-PRIMULTI Cardiac Magnetic Resonance Substudy

Standard

Complete Revascularization Versus Culprit Lesion Only in Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease: A DANAMI-3-PRIMULTI Cardiac Magnetic Resonance Substudy. / Kyhl, Kasper; Ahtarovski, Kiril Aleksov; Nepper-Christensen, Lars; Ekström, Kathrine; Ghotbi, Adam Ali; Schoos, Mikkel; Göransson, Christoffer; Bertelsen, Litten; Helqvist, Steffen; Holmvang, Lene; Jørgensen, Erik; Pedersen, Frants; Saunamäki, Kari; Clemmensen, Peter; De Backer, Ole; Høfsten, Dan Eik; Køber, Lars; Kelbæk, Henning; Vejlstrup, Niels; Lønborg, Jacob; Engstrøm, Thomas.

in: JACC-CARDIOVASC INTE, Jahrgang 12, Nr. 8, 22.04.2019, S. 721-730.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kyhl, K, Ahtarovski, KA, Nepper-Christensen, L, Ekström, K, Ghotbi, AA, Schoos, M, Göransson, C, Bertelsen, L, Helqvist, S, Holmvang, L, Jørgensen, E, Pedersen, F, Saunamäki, K, Clemmensen, P, De Backer, O, Høfsten, DE, Køber, L, Kelbæk, H, Vejlstrup, N, Lønborg, J & Engstrøm, T 2019, 'Complete Revascularization Versus Culprit Lesion Only in Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease: A DANAMI-3-PRIMULTI Cardiac Magnetic Resonance Substudy', JACC-CARDIOVASC INTE, Jg. 12, Nr. 8, S. 721-730. https://doi.org/10.1016/j.jcin.2019.01.248

APA

Kyhl, K., Ahtarovski, K. A., Nepper-Christensen, L., Ekström, K., Ghotbi, A. A., Schoos, M., Göransson, C., Bertelsen, L., Helqvist, S., Holmvang, L., Jørgensen, E., Pedersen, F., Saunamäki, K., Clemmensen, P., De Backer, O., Høfsten, D. E., Køber, L., Kelbæk, H., Vejlstrup, N., ... Engstrøm, T. (2019). Complete Revascularization Versus Culprit Lesion Only in Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease: A DANAMI-3-PRIMULTI Cardiac Magnetic Resonance Substudy. JACC-CARDIOVASC INTE, 12(8), 721-730. https://doi.org/10.1016/j.jcin.2019.01.248

Vancouver

Kyhl K, Ahtarovski KA, Nepper-Christensen L, Ekström K, Ghotbi AA, Schoos M et al. Complete Revascularization Versus Culprit Lesion Only in Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease: A DANAMI-3-PRIMULTI Cardiac Magnetic Resonance Substudy. JACC-CARDIOVASC INTE. 2019 Apr 22;12(8):721-730. https://doi.org/10.1016/j.jcin.2019.01.248

Bibtex

@article{037ad22581434c669536c0797b6fc4d5,
title = "Complete Revascularization Versus Culprit Lesion Only in Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease: A DANAMI-3-PRIMULTI Cardiac Magnetic Resonance Substudy",
abstract = "OBJECTIVES: The aim of this study was to evaluate the effect of fractional flow reserve (FFR)-guided revascularization compared with culprit-only percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) on infarct size, left ventricular (LV), function, LV remodeling, and the presence of nonculprit infarctions.BACKGROUND: Patients with STEMI with multivessel disease might have improved clinical outcomes after complete revascularization compared with PCI of the infarct-related artery only, but the impact on infarct size, LV function, and remodeling as well as the risk for periprocedural infarction are unknown.METHODS: In this substudy of the DANAMI-3 (Third Danish Trial in Acute Myocardial Infarction)-PRIMULTI (Primary PCI in Patients With ST-Elevation Myocardial Infarction and Multivessel Disease: Treatment of Culprit Lesion Only or Complete Revascularization) randomized trial, patients with STEMI with multivessel disease were randomized to receive either complete FFR-guided revascularization or PCI of the culprit vessel only. The patients underwent cardiac magnetic resonance imaging during index admission and at 3-month follow-up.RESULTS: A total of 280 patients (136 patients with infarct-related and 144 with complete FFR-guided revascularization) were included. There were no differences in final infarct size (median 12% [interquartile range: 5% to 19%] vs. 11% [interquartile range: 4% to 18%]; p = 0.62), myocardial salvage index (median 0.71 [interquartile range: 0.54 to 0.89] vs. 0.66 [interquartile range: 0.55 to 0.87]; p = 0.49), LV ejection fraction (mean 58 ± 9% vs. 59 ± 9%; p = 0.39), and LV end-systolic volume remodeling (mean 7 ± 22 ml vs. 7 ± 19 ml; p = 0.63). New nonculprit infarction occurring after the nonculprit intervention was numerically more frequent among patients treated with complete revascularization (6 [4.5%] vs. 1 [0.8%]; p = 0.12).CONCLUSIONS: Complete FFR-guided revascularization in patients with STEMI and multivessel disease did not affect final infarct size, LV function, or remodeling compared with culprit-only PCI.",
keywords = "Aged, Coronary Angiography, Coronary Artery Disease/diagnostic imaging, Denmark, Female, Fractional Flow Reserve, Myocardial, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Percutaneous Coronary Intervention/adverse effects, Predictive Value of Tests, Recovery of Function, ST Elevation Myocardial Infarction/diagnostic imaging, Stroke Volume, Time Factors, Treatment Outcome, Ventricular Function, Left, Ventricular Remodeling",
author = "Kasper Kyhl and Ahtarovski, {Kiril Aleksov} and Lars Nepper-Christensen and Kathrine Ekstr{\"o}m and Ghotbi, {Adam Ali} and Mikkel Schoos and Christoffer G{\"o}ransson and Litten Bertelsen and Steffen Helqvist and Lene Holmvang and Erik J{\o}rgensen and Frants Pedersen and Kari Saunam{\"a}ki and Peter Clemmensen and {De Backer}, Ole and H{\o}fsten, {Dan Eik} and Lars K{\o}ber and Henning Kelb{\ae}k and Niels Vejlstrup and Jacob L{\o}nborg and Thomas Engstr{\o}m",
note = "Copyright {\textcopyright} 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = apr,
day = "22",
doi = "10.1016/j.jcin.2019.01.248",
language = "English",
volume = "12",
pages = "721--730",
journal = "JACC-CARDIOVASC INTE",
issn = "1936-8798",
publisher = "Elsevier Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Complete Revascularization Versus Culprit Lesion Only in Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease: A DANAMI-3-PRIMULTI Cardiac Magnetic Resonance Substudy

AU - Kyhl, Kasper

AU - Ahtarovski, Kiril Aleksov

AU - Nepper-Christensen, Lars

AU - Ekström, Kathrine

AU - Ghotbi, Adam Ali

AU - Schoos, Mikkel

AU - Göransson, Christoffer

AU - Bertelsen, Litten

AU - Helqvist, Steffen

AU - Holmvang, Lene

AU - Jørgensen, Erik

AU - Pedersen, Frants

AU - Saunamäki, Kari

AU - Clemmensen, Peter

AU - De Backer, Ole

AU - Høfsten, Dan Eik

AU - Køber, Lars

AU - Kelbæk, Henning

AU - Vejlstrup, Niels

AU - Lønborg, Jacob

AU - Engstrøm, Thomas

N1 - Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

PY - 2019/4/22

Y1 - 2019/4/22

N2 - OBJECTIVES: The aim of this study was to evaluate the effect of fractional flow reserve (FFR)-guided revascularization compared with culprit-only percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) on infarct size, left ventricular (LV), function, LV remodeling, and the presence of nonculprit infarctions.BACKGROUND: Patients with STEMI with multivessel disease might have improved clinical outcomes after complete revascularization compared with PCI of the infarct-related artery only, but the impact on infarct size, LV function, and remodeling as well as the risk for periprocedural infarction are unknown.METHODS: In this substudy of the DANAMI-3 (Third Danish Trial in Acute Myocardial Infarction)-PRIMULTI (Primary PCI in Patients With ST-Elevation Myocardial Infarction and Multivessel Disease: Treatment of Culprit Lesion Only or Complete Revascularization) randomized trial, patients with STEMI with multivessel disease were randomized to receive either complete FFR-guided revascularization or PCI of the culprit vessel only. The patients underwent cardiac magnetic resonance imaging during index admission and at 3-month follow-up.RESULTS: A total of 280 patients (136 patients with infarct-related and 144 with complete FFR-guided revascularization) were included. There were no differences in final infarct size (median 12% [interquartile range: 5% to 19%] vs. 11% [interquartile range: 4% to 18%]; p = 0.62), myocardial salvage index (median 0.71 [interquartile range: 0.54 to 0.89] vs. 0.66 [interquartile range: 0.55 to 0.87]; p = 0.49), LV ejection fraction (mean 58 ± 9% vs. 59 ± 9%; p = 0.39), and LV end-systolic volume remodeling (mean 7 ± 22 ml vs. 7 ± 19 ml; p = 0.63). New nonculprit infarction occurring after the nonculprit intervention was numerically more frequent among patients treated with complete revascularization (6 [4.5%] vs. 1 [0.8%]; p = 0.12).CONCLUSIONS: Complete FFR-guided revascularization in patients with STEMI and multivessel disease did not affect final infarct size, LV function, or remodeling compared with culprit-only PCI.

AB - OBJECTIVES: The aim of this study was to evaluate the effect of fractional flow reserve (FFR)-guided revascularization compared with culprit-only percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) on infarct size, left ventricular (LV), function, LV remodeling, and the presence of nonculprit infarctions.BACKGROUND: Patients with STEMI with multivessel disease might have improved clinical outcomes after complete revascularization compared with PCI of the infarct-related artery only, but the impact on infarct size, LV function, and remodeling as well as the risk for periprocedural infarction are unknown.METHODS: In this substudy of the DANAMI-3 (Third Danish Trial in Acute Myocardial Infarction)-PRIMULTI (Primary PCI in Patients With ST-Elevation Myocardial Infarction and Multivessel Disease: Treatment of Culprit Lesion Only or Complete Revascularization) randomized trial, patients with STEMI with multivessel disease were randomized to receive either complete FFR-guided revascularization or PCI of the culprit vessel only. The patients underwent cardiac magnetic resonance imaging during index admission and at 3-month follow-up.RESULTS: A total of 280 patients (136 patients with infarct-related and 144 with complete FFR-guided revascularization) were included. There were no differences in final infarct size (median 12% [interquartile range: 5% to 19%] vs. 11% [interquartile range: 4% to 18%]; p = 0.62), myocardial salvage index (median 0.71 [interquartile range: 0.54 to 0.89] vs. 0.66 [interquartile range: 0.55 to 0.87]; p = 0.49), LV ejection fraction (mean 58 ± 9% vs. 59 ± 9%; p = 0.39), and LV end-systolic volume remodeling (mean 7 ± 22 ml vs. 7 ± 19 ml; p = 0.63). New nonculprit infarction occurring after the nonculprit intervention was numerically more frequent among patients treated with complete revascularization (6 [4.5%] vs. 1 [0.8%]; p = 0.12).CONCLUSIONS: Complete FFR-guided revascularization in patients with STEMI and multivessel disease did not affect final infarct size, LV function, or remodeling compared with culprit-only PCI.

KW - Aged

KW - Coronary Angiography

KW - Coronary Artery Disease/diagnostic imaging

KW - Denmark

KW - Female

KW - Fractional Flow Reserve, Myocardial

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Percutaneous Coronary Intervention/adverse effects

KW - Predictive Value of Tests

KW - Recovery of Function

KW - ST Elevation Myocardial Infarction/diagnostic imaging

KW - Stroke Volume

KW - Time Factors

KW - Treatment Outcome

KW - Ventricular Function, Left

KW - Ventricular Remodeling

U2 - 10.1016/j.jcin.2019.01.248

DO - 10.1016/j.jcin.2019.01.248

M3 - SCORING: Journal article

C2 - 31000010

VL - 12

SP - 721

EP - 730

JO - JACC-CARDIOVASC INTE

JF - JACC-CARDIOVASC INTE

SN - 1936-8798

IS - 8

ER -