Comparative investigation of keratin-filaments in normal tissues and tumours of skin, oral mucosa, salivary glands and thymus.
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Comparative investigation of keratin-filaments in normal tissues and tumours of skin, oral mucosa, salivary glands and thymus. / Löning, Thomas; Viac, J; Caselitz, J; Thivolet, J; Otto, H F; Seifert, G.
in: PATHOL RES PRACT, Jahrgang 175, Nr. 2-3, 2-3, 1982, S. 256-265.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Comparative investigation of keratin-filaments in normal tissues and tumours of skin, oral mucosa, salivary glands and thymus.
AU - Löning, Thomas
AU - Viac, J
AU - Caselitz, J
AU - Thivolet, J
AU - Otto, H F
AU - Seifert, G
PY - 1982
Y1 - 1982
N2 - Antibodies against different fractions of keratins can be helpful in various fields of special pathology. Antibodies against "small" and "large" keratins permit to evaluate epithelial maturation in skin and oral mucosa. In addition, disturbances of keratinization during inflammatory processes and malignant transformation can be analyzed. The main application of antibodies against the entire fractions of keratins is the detection of the epithelial nature of a neoplasm. By this tool, particular problems in surgical pathology concerning differential diagnosis can be handled in an easier way. Among the different tissues and their neoplasms, examples of the analysis of thymus tumours and salivary gland tumours are presented. Immunoreactivity with keratin antibodies depends crucially on tissue processing. In the normal diagnostic procedure, good results are regularly obtained if cryostat or Bouin-fixed paraffin-embedded sections are used.
AB - Antibodies against different fractions of keratins can be helpful in various fields of special pathology. Antibodies against "small" and "large" keratins permit to evaluate epithelial maturation in skin and oral mucosa. In addition, disturbances of keratinization during inflammatory processes and malignant transformation can be analyzed. The main application of antibodies against the entire fractions of keratins is the detection of the epithelial nature of a neoplasm. By this tool, particular problems in surgical pathology concerning differential diagnosis can be handled in an easier way. Among the different tissues and their neoplasms, examples of the analysis of thymus tumours and salivary gland tumours are presented. Immunoreactivity with keratin antibodies depends crucially on tissue processing. In the normal diagnostic procedure, good results are regularly obtained if cryostat or Bouin-fixed paraffin-embedded sections are used.
M3 - SCORING: Zeitschriftenaufsatz
VL - 175
SP - 256
EP - 265
JO - PATHOL RES PRACT
JF - PATHOL RES PRACT
SN - 0344-0338
IS - 2-3
M1 - 2-3
ER -