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Comparative analysis of the effect of prostatic invasion patterns on cancer-specific mortality after radical cystectomy in pT4a urothelial carcinoma of the bladder

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Comparative analysis of the effect of prostatic invasion patterns on cancer-specific mortality after radical cystectomy in pT4a urothelial carcinoma of the bladder. / Vallo, Stefan; Gilfrich, Christian; Burger, Maximilian; Volkmer, Björn; Boehm, Katharina; Rink, Michael; Chun, Felix K; Roghmann, Florian; Novotny, Vladimir; Mani, Jens; Brisuda, Antonin; Mayr, Roman; Stredele, Regina; Noldus, Joachim; Schnabel, Marco; May, Matthias; Fritsche, Hans-Martin; Pycha, Armin; Martini, Thomas; Wirth, Manfred; Roigas, Jan; Bastian, Patrick J; Nuhn, Philipp; Dahlem, Roland; Haferkamp, Axel; Fisch, Margit; Aziz, Atiqullah.

in: UROL ONCOL-SEMIN ORI, Jahrgang 34, Nr. 10, 10.2016, S. 432.e1-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Vallo, S, Gilfrich, C, Burger, M, Volkmer, B, Boehm, K, Rink, M, Chun, FK, Roghmann, F, Novotny, V, Mani, J, Brisuda, A, Mayr, R, Stredele, R, Noldus, J, Schnabel, M, May, M, Fritsche, H-M, Pycha, A, Martini, T, Wirth, M, Roigas, J, Bastian, PJ, Nuhn, P, Dahlem, R, Haferkamp, A, Fisch, M & Aziz, A 2016, 'Comparative analysis of the effect of prostatic invasion patterns on cancer-specific mortality after radical cystectomy in pT4a urothelial carcinoma of the bladder', UROL ONCOL-SEMIN ORI, Jg. 34, Nr. 10, S. 432.e1-8. https://doi.org/10.1016/j.urolonc.2016.05.008

APA

Vallo, S., Gilfrich, C., Burger, M., Volkmer, B., Boehm, K., Rink, M., Chun, F. K., Roghmann, F., Novotny, V., Mani, J., Brisuda, A., Mayr, R., Stredele, R., Noldus, J., Schnabel, M., May, M., Fritsche, H-M., Pycha, A., Martini, T., ... Aziz, A. (2016). Comparative analysis of the effect of prostatic invasion patterns on cancer-specific mortality after radical cystectomy in pT4a urothelial carcinoma of the bladder. UROL ONCOL-SEMIN ORI, 34(10), 432.e1-8. https://doi.org/10.1016/j.urolonc.2016.05.008

Vancouver

Vallo S, Gilfrich C, Burger M, Volkmer B, Boehm K, Rink M et al. Comparative analysis of the effect of prostatic invasion patterns on cancer-specific mortality after radical cystectomy in pT4a urothelial carcinoma of the bladder. UROL ONCOL-SEMIN ORI. 2016 Okt;34(10):432.e1-8. https://doi.org/10.1016/j.urolonc.2016.05.008

Bibtex

@article{25dc3d739109452698eca6d8104cd577,
title = "Comparative analysis of the effect of prostatic invasion patterns on cancer-specific mortality after radical cystectomy in pT4a urothelial carcinoma of the bladder",
abstract = "PURPOSE: To evaluate the prognostic relevance of different prostatic invasion patterns in pT4a urothelial carcinoma of the bladder (UCB) after radical cystectomy.MATERIALS AND METHODS: Our study comprised a total of 358 men with pT4a UCB. Patients were divided in 2 groups-group A with stromal infiltration of the prostate via the prostatic urethra with additional muscle-invasive UCB (n = 121, 33.8%) and group B with continuous infiltration of the prostate through the entire bladder wall (n = 237, 66.2%). The effect of age, tumor grade, carcinoma in situ, lymphovascular invasion, soft tissue surgical margin, lymph node metastases, administration of adjuvant chemotherapy, and prostatic invasion patterns on cancer-specific mortality (CSM) was evaluated using competing-risk regression analysis. Decision curve analysis was used to evaluate the net benefit of including the variable invasion pattern within our model.RESULTS: The estimated 5-year CSM-rates for group A and B were 50.1% and 66.0%, respectively. In multivariable competing-risk analysis, lymph node metastases (hazard ratio [HR] = 1.73, P<0.001), lymphovascular invasion (HR = 1.62, P = 0.0023), soft tissue surgical margin (HR = 1.49, P = 0.026), absence of adjuvant chemotherapy (HR = 2.11, P<0.001), and tumor infiltration of the prostate by continuous infiltration of the entire bladder wall (HR = 1.37, P = 0.044) were significantly associated with a higher risk for CSM. Decision curve analysis showed a net benefit of our model including the variable invasion pattern.CONCLUSIONS: Continuous infiltration of the prostate through the entire bladder wall showed an adverse effect on CSM. Besides including these patients into clinical trials for an adjuvant therapy, we recommend including prostatic invasion patterns in predictive models in pT4a UCB in men.",
keywords = "Journal Article",
author = "Stefan Vallo and Christian Gilfrich and Maximilian Burger and Bj{\"o}rn Volkmer and Katharina Boehm and Michael Rink and Chun, {Felix K} and Florian Roghmann and Vladimir Novotny and Jens Mani and Antonin Brisuda and Roman Mayr and Regina Stredele and Joachim Noldus and Marco Schnabel and Matthias May and Hans-Martin Fritsche and Armin Pycha and Thomas Martini and Manfred Wirth and Jan Roigas and Bastian, {Patrick J} and Philipp Nuhn and Roland Dahlem and Axel Haferkamp and Margit Fisch and Atiqullah Aziz",
note = "Copyright {\textcopyright} 2016 Elsevier Inc. All rights reserved.",
year = "2016",
month = oct,
doi = "10.1016/j.urolonc.2016.05.008",
language = "English",
volume = "34",
pages = "432.e1--8",
journal = "UROL ONCOL-SEMIN ORI",
issn = "1078-1439",
publisher = "Elsevier Inc.",
number = "10",

}

RIS

TY - JOUR

T1 - Comparative analysis of the effect of prostatic invasion patterns on cancer-specific mortality after radical cystectomy in pT4a urothelial carcinoma of the bladder

AU - Vallo, Stefan

AU - Gilfrich, Christian

AU - Burger, Maximilian

AU - Volkmer, Björn

AU - Boehm, Katharina

AU - Rink, Michael

AU - Chun, Felix K

AU - Roghmann, Florian

AU - Novotny, Vladimir

AU - Mani, Jens

AU - Brisuda, Antonin

AU - Mayr, Roman

AU - Stredele, Regina

AU - Noldus, Joachim

AU - Schnabel, Marco

AU - May, Matthias

AU - Fritsche, Hans-Martin

AU - Pycha, Armin

AU - Martini, Thomas

AU - Wirth, Manfred

AU - Roigas, Jan

AU - Bastian, Patrick J

AU - Nuhn, Philipp

AU - Dahlem, Roland

AU - Haferkamp, Axel

AU - Fisch, Margit

AU - Aziz, Atiqullah

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2016/10

Y1 - 2016/10

N2 - PURPOSE: To evaluate the prognostic relevance of different prostatic invasion patterns in pT4a urothelial carcinoma of the bladder (UCB) after radical cystectomy.MATERIALS AND METHODS: Our study comprised a total of 358 men with pT4a UCB. Patients were divided in 2 groups-group A with stromal infiltration of the prostate via the prostatic urethra with additional muscle-invasive UCB (n = 121, 33.8%) and group B with continuous infiltration of the prostate through the entire bladder wall (n = 237, 66.2%). The effect of age, tumor grade, carcinoma in situ, lymphovascular invasion, soft tissue surgical margin, lymph node metastases, administration of adjuvant chemotherapy, and prostatic invasion patterns on cancer-specific mortality (CSM) was evaluated using competing-risk regression analysis. Decision curve analysis was used to evaluate the net benefit of including the variable invasion pattern within our model.RESULTS: The estimated 5-year CSM-rates for group A and B were 50.1% and 66.0%, respectively. In multivariable competing-risk analysis, lymph node metastases (hazard ratio [HR] = 1.73, P<0.001), lymphovascular invasion (HR = 1.62, P = 0.0023), soft tissue surgical margin (HR = 1.49, P = 0.026), absence of adjuvant chemotherapy (HR = 2.11, P<0.001), and tumor infiltration of the prostate by continuous infiltration of the entire bladder wall (HR = 1.37, P = 0.044) were significantly associated with a higher risk for CSM. Decision curve analysis showed a net benefit of our model including the variable invasion pattern.CONCLUSIONS: Continuous infiltration of the prostate through the entire bladder wall showed an adverse effect on CSM. Besides including these patients into clinical trials for an adjuvant therapy, we recommend including prostatic invasion patterns in predictive models in pT4a UCB in men.

AB - PURPOSE: To evaluate the prognostic relevance of different prostatic invasion patterns in pT4a urothelial carcinoma of the bladder (UCB) after radical cystectomy.MATERIALS AND METHODS: Our study comprised a total of 358 men with pT4a UCB. Patients were divided in 2 groups-group A with stromal infiltration of the prostate via the prostatic urethra with additional muscle-invasive UCB (n = 121, 33.8%) and group B with continuous infiltration of the prostate through the entire bladder wall (n = 237, 66.2%). The effect of age, tumor grade, carcinoma in situ, lymphovascular invasion, soft tissue surgical margin, lymph node metastases, administration of adjuvant chemotherapy, and prostatic invasion patterns on cancer-specific mortality (CSM) was evaluated using competing-risk regression analysis. Decision curve analysis was used to evaluate the net benefit of including the variable invasion pattern within our model.RESULTS: The estimated 5-year CSM-rates for group A and B were 50.1% and 66.0%, respectively. In multivariable competing-risk analysis, lymph node metastases (hazard ratio [HR] = 1.73, P<0.001), lymphovascular invasion (HR = 1.62, P = 0.0023), soft tissue surgical margin (HR = 1.49, P = 0.026), absence of adjuvant chemotherapy (HR = 2.11, P<0.001), and tumor infiltration of the prostate by continuous infiltration of the entire bladder wall (HR = 1.37, P = 0.044) were significantly associated with a higher risk for CSM. Decision curve analysis showed a net benefit of our model including the variable invasion pattern.CONCLUSIONS: Continuous infiltration of the prostate through the entire bladder wall showed an adverse effect on CSM. Besides including these patients into clinical trials for an adjuvant therapy, we recommend including prostatic invasion patterns in predictive models in pT4a UCB in men.

KW - Journal Article

U2 - 10.1016/j.urolonc.2016.05.008

DO - 10.1016/j.urolonc.2016.05.008

M3 - SCORING: Journal article

C2 - 27283218

VL - 34

SP - 432.e1-8

JO - UROL ONCOL-SEMIN ORI

JF - UROL ONCOL-SEMIN ORI

SN - 1078-1439

IS - 10

ER -