Community acquired respiratory virus infections in cancer patients-Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology
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Community acquired respiratory virus infections in cancer patients-Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology. / von Lilienfeld-Toal, Marie; Berger, Annemarie; Christopeit, Maximilian; Hentrich, Marcus; Heussel, Claus Peter; Kalkreuth, Jana; Klein, Michael; Kochanek, Matthias; Penack, Olaf; Hauf, Elke; Rieger, Christina; Silling, Gerda; Vehreschild, Maria; Weber, Thomas; Wolf, Hans-Heinrich; Lehners, Nicola; Schalk, Enrico; Mayer, Karin.
in: EUR J CANCER, Jahrgang 67, 11.2016, S. 200-212.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Community acquired respiratory virus infections in cancer patients-Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology
AU - von Lilienfeld-Toal, Marie
AU - Berger, Annemarie
AU - Christopeit, Maximilian
AU - Hentrich, Marcus
AU - Heussel, Claus Peter
AU - Kalkreuth, Jana
AU - Klein, Michael
AU - Kochanek, Matthias
AU - Penack, Olaf
AU - Hauf, Elke
AU - Rieger, Christina
AU - Silling, Gerda
AU - Vehreschild, Maria
AU - Weber, Thomas
AU - Wolf, Hans-Heinrich
AU - Lehners, Nicola
AU - Schalk, Enrico
AU - Mayer, Karin
N1 - Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2016/11
Y1 - 2016/11
N2 - BACKGROUND: Community acquired viruses (CRVs) may cause severe disease in cancer patients. Thus, efforts should be made to diagnose CRV rapidly and manage CRV infections accordingly.METHODS: A panel of 18 clinicians from the Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology have convened to assess the available literature and provide recommendations on the management of CRV infections including influenza, respiratory syncytial virus, parainfluenza virus, human metapneumovirus and adenovirus.RESULTS: CRV infections in cancer patients may lead to pneumonia in approximately 30% of the cases, with an associated mortality of around 25%. For diagnosis of a CRV infection, combined nasal/throat swabs or washes/aspirates give the best results and nucleic acid amplification based-techniques (NAT) should be used to detect the pathogen. Hand hygiene, contact isolation and face masks have been shown to be of benefit as general infection management. Causal treatment can be given for influenza, using a neuraminidase inhibitor, and respiratory syncytial virus, using ribavirin in addition to intravenous immunoglobulins. Ribavirin has also been used to treat parainfluenza virus and human metapneumovirus, but data are inconclusive in this setting. Cidofovir is used to treat adenovirus pneumonitis.CONCLUSIONS: CRV infections may pose a vital threat to patients with underlying malignancy. This guideline provides information on diagnosis and treatment to improve the outcome.
AB - BACKGROUND: Community acquired viruses (CRVs) may cause severe disease in cancer patients. Thus, efforts should be made to diagnose CRV rapidly and manage CRV infections accordingly.METHODS: A panel of 18 clinicians from the Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology have convened to assess the available literature and provide recommendations on the management of CRV infections including influenza, respiratory syncytial virus, parainfluenza virus, human metapneumovirus and adenovirus.RESULTS: CRV infections in cancer patients may lead to pneumonia in approximately 30% of the cases, with an associated mortality of around 25%. For diagnosis of a CRV infection, combined nasal/throat swabs or washes/aspirates give the best results and nucleic acid amplification based-techniques (NAT) should be used to detect the pathogen. Hand hygiene, contact isolation and face masks have been shown to be of benefit as general infection management. Causal treatment can be given for influenza, using a neuraminidase inhibitor, and respiratory syncytial virus, using ribavirin in addition to intravenous immunoglobulins. Ribavirin has also been used to treat parainfluenza virus and human metapneumovirus, but data are inconclusive in this setting. Cidofovir is used to treat adenovirus pneumonitis.CONCLUSIONS: CRV infections may pose a vital threat to patients with underlying malignancy. This guideline provides information on diagnosis and treatment to improve the outcome.
U2 - 10.1016/j.ejca.2016.08.015
DO - 10.1016/j.ejca.2016.08.015
M3 - SCORING: Journal article
C2 - 27681877
VL - 67
SP - 200
EP - 212
JO - EUR J CANCER
JF - EUR J CANCER
SN - 0959-8049
ER -