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Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence

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Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence. / Schilling, Christina; Kühn, Simone; Romanowski, Alexander; Banaschewski, Tobias; Barbot, Alexis; Barker, Gareth J; Brühl, Rüdiger; Büchel, Christian; Charlet, Katrin; Conrod, Patricia J; Czech, Katharina; Dalley, Jeff W; Flor, Herta; Häke, Ines; Ittermann, Bernd; Ivanov, Nikolay; Mann, Karl; Lüdemann, Katharina; Martinot, Jean-Luc; Palafox, Carla; Paus, Tomas; Poline, Jean-Baptiste; Reuter, Jan; Rietschel, Marcella; Robbins, Trevor W; Smolka, Michael N; Ströhle, Andreas; Walaszek, Bernadeta; Kathmann, Norbert; Schumann, Gunter; Heinz, Andreas; Garavan, Hugh; Gallinat, Jürgen; IMAGEN Consortium.

in: HUM BRAIN MAPP, Jahrgang 34, Nr. 2, 01.02.2013, S. 374-83.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schilling, C, Kühn, S, Romanowski, A, Banaschewski, T, Barbot, A, Barker, GJ, Brühl, R, Büchel, C, Charlet, K, Conrod, PJ, Czech, K, Dalley, JW, Flor, H, Häke, I, Ittermann, B, Ivanov, N, Mann, K, Lüdemann, K, Martinot, J-L, Palafox, C, Paus, T, Poline, J-B, Reuter, J, Rietschel, M, Robbins, TW, Smolka, MN, Ströhle, A, Walaszek, B, Kathmann, N, Schumann, G, Heinz, A, Garavan, H, Gallinat, J & IMAGEN Consortium 2013, 'Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence', HUM BRAIN MAPP, Jg. 34, Nr. 2, S. 374-83. https://doi.org/10.1002/hbm.21446

APA

Schilling, C., Kühn, S., Romanowski, A., Banaschewski, T., Barbot, A., Barker, G. J., Brühl, R., Büchel, C., Charlet, K., Conrod, P. J., Czech, K., Dalley, J. W., Flor, H., Häke, I., Ittermann, B., Ivanov, N., Mann, K., Lüdemann, K., Martinot, J-L., ... IMAGEN Consortium (2013). Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence. HUM BRAIN MAPP, 34(2), 374-83. https://doi.org/10.1002/hbm.21446

Vancouver

Schilling C, Kühn S, Romanowski A, Banaschewski T, Barbot A, Barker GJ et al. Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence. HUM BRAIN MAPP. 2013 Feb 1;34(2):374-83. https://doi.org/10.1002/hbm.21446

Bibtex

@article{3a149caeac63425080a72cd59a69af7f,
title = "Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence",
abstract = "BACKGROUND: Trait impulsiveness is a potential factor that predicts both substance use and certain psychiatric disorders. This study investigates whether there are common structural cerebral correlates of trait impulsiveness and cognitive functioning in a large sample of healthy adolescents from the IMAGEN project.METHODS: Clusters of gray matter (GM) volume associated with trait impulsiveness, Cloningers' revised temperament, and character inventory impulsiveness (TCI-R-I) were identified in a whole brain analysis using optimized voxel-based morphometry in 115 healthy 14-year-olds. The clusters were tested for correlations with performance on the nonverbal tests (Block Design, BD; Matrix Reasoning, MT) of the Wechsler Scale of Intelligence for Children IV reflecting perceptual reasoning.RESULTS: Cloningers' impulsiveness (TCI-R-I) score was significantly inversely associated with GM volume in left orbitofrontal cortex (OFC). Frontal clusters found were positively correlated with performance in perceptual reasoning tasks (Bonferroni corrected). No significant correlations between TCI-R-I and perceptual reasoning were observed.CONCLUSIONS: The neural correlate of trait impulsiveness in the OFC matches an area where brain function has previously been related to inhibitory control. Additionally, orbitofrontal GM volume was associated with scores for perceptual reasoning. The data show for the first time structural correlates of both cognitive functioning and impulsiveness in healthy adolescent subjects.",
keywords = "Adolescent, Brain, Brain Mapping, Cluster Analysis, Female, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Impulsive Behavior, Magnetic Resonance Imaging, Male, Mental Processes, Neuropsychological Tests, Perception, Personality, Personality Tests, Psychomotor Performance, Wechsler Scales",
author = "Christina Schilling and Simone K{\"u}hn and Alexander Romanowski and Tobias Banaschewski and Alexis Barbot and Barker, {Gareth J} and R{\"u}diger Br{\"u}hl and Christian B{\"u}chel and Katrin Charlet and Conrod, {Patricia J} and Katharina Czech and Dalley, {Jeff W} and Herta Flor and Ines H{\"a}ke and Bernd Ittermann and Nikolay Ivanov and Karl Mann and Katharina L{\"u}demann and Jean-Luc Martinot and Carla Palafox and Tomas Paus and Jean-Baptiste Poline and Jan Reuter and Marcella Rietschel and Robbins, {Trevor W} and Smolka, {Michael N} and Andreas Str{\"o}hle and Bernadeta Walaszek and Norbert Kathmann and Gunter Schumann and Andreas Heinz and Hugh Garavan and J{\"u}rgen Gallinat and {IMAGEN Consortium}",
note = "Copyright {\textcopyright} 2011 Wiley Periodicals, Inc.",
year = "2013",
month = feb,
day = "1",
doi = "10.1002/hbm.21446",
language = "English",
volume = "34",
pages = "374--83",
journal = "HUM BRAIN MAPP",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence

AU - Schilling, Christina

AU - Kühn, Simone

AU - Romanowski, Alexander

AU - Banaschewski, Tobias

AU - Barbot, Alexis

AU - Barker, Gareth J

AU - Brühl, Rüdiger

AU - Büchel, Christian

AU - Charlet, Katrin

AU - Conrod, Patricia J

AU - Czech, Katharina

AU - Dalley, Jeff W

AU - Flor, Herta

AU - Häke, Ines

AU - Ittermann, Bernd

AU - Ivanov, Nikolay

AU - Mann, Karl

AU - Lüdemann, Katharina

AU - Martinot, Jean-Luc

AU - Palafox, Carla

AU - Paus, Tomas

AU - Poline, Jean-Baptiste

AU - Reuter, Jan

AU - Rietschel, Marcella

AU - Robbins, Trevor W

AU - Smolka, Michael N

AU - Ströhle, Andreas

AU - Walaszek, Bernadeta

AU - Kathmann, Norbert

AU - Schumann, Gunter

AU - Heinz, Andreas

AU - Garavan, Hugh

AU - Gallinat, Jürgen

AU - IMAGEN Consortium

N1 - Copyright © 2011 Wiley Periodicals, Inc.

PY - 2013/2/1

Y1 - 2013/2/1

N2 - BACKGROUND: Trait impulsiveness is a potential factor that predicts both substance use and certain psychiatric disorders. This study investigates whether there are common structural cerebral correlates of trait impulsiveness and cognitive functioning in a large sample of healthy adolescents from the IMAGEN project.METHODS: Clusters of gray matter (GM) volume associated with trait impulsiveness, Cloningers' revised temperament, and character inventory impulsiveness (TCI-R-I) were identified in a whole brain analysis using optimized voxel-based morphometry in 115 healthy 14-year-olds. The clusters were tested for correlations with performance on the nonverbal tests (Block Design, BD; Matrix Reasoning, MT) of the Wechsler Scale of Intelligence for Children IV reflecting perceptual reasoning.RESULTS: Cloningers' impulsiveness (TCI-R-I) score was significantly inversely associated with GM volume in left orbitofrontal cortex (OFC). Frontal clusters found were positively correlated with performance in perceptual reasoning tasks (Bonferroni corrected). No significant correlations between TCI-R-I and perceptual reasoning were observed.CONCLUSIONS: The neural correlate of trait impulsiveness in the OFC matches an area where brain function has previously been related to inhibitory control. Additionally, orbitofrontal GM volume was associated with scores for perceptual reasoning. The data show for the first time structural correlates of both cognitive functioning and impulsiveness in healthy adolescent subjects.

AB - BACKGROUND: Trait impulsiveness is a potential factor that predicts both substance use and certain psychiatric disorders. This study investigates whether there are common structural cerebral correlates of trait impulsiveness and cognitive functioning in a large sample of healthy adolescents from the IMAGEN project.METHODS: Clusters of gray matter (GM) volume associated with trait impulsiveness, Cloningers' revised temperament, and character inventory impulsiveness (TCI-R-I) were identified in a whole brain analysis using optimized voxel-based morphometry in 115 healthy 14-year-olds. The clusters were tested for correlations with performance on the nonverbal tests (Block Design, BD; Matrix Reasoning, MT) of the Wechsler Scale of Intelligence for Children IV reflecting perceptual reasoning.RESULTS: Cloningers' impulsiveness (TCI-R-I) score was significantly inversely associated with GM volume in left orbitofrontal cortex (OFC). Frontal clusters found were positively correlated with performance in perceptual reasoning tasks (Bonferroni corrected). No significant correlations between TCI-R-I and perceptual reasoning were observed.CONCLUSIONS: The neural correlate of trait impulsiveness in the OFC matches an area where brain function has previously been related to inhibitory control. Additionally, orbitofrontal GM volume was associated with scores for perceptual reasoning. The data show for the first time structural correlates of both cognitive functioning and impulsiveness in healthy adolescent subjects.

KW - Adolescent

KW - Brain

KW - Brain Mapping

KW - Cluster Analysis

KW - Female

KW - Frontal Lobe

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Impulsive Behavior

KW - Magnetic Resonance Imaging

KW - Male

KW - Mental Processes

KW - Neuropsychological Tests

KW - Perception

KW - Personality

KW - Personality Tests

KW - Psychomotor Performance

KW - Wechsler Scales

U2 - 10.1002/hbm.21446

DO - 10.1002/hbm.21446

M3 - SCORING: Journal article

C2 - 22076840

VL - 34

SP - 374

EP - 383

JO - HUM BRAIN MAPP

JF - HUM BRAIN MAPP

SN - 1065-9471

IS - 2

ER -