Common data elements reported on middle meningeal artery embolization in chronic subdural hematoma: an interactive systematic review of recent trials
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Common data elements reported on middle meningeal artery embolization in chronic subdural hematoma: an interactive systematic review of recent trials. / Adusumilli, Gautam; Ghozy, Sherief; Kallmes, Kevin M; Hardy, Nicole; Tarchand, Ranita; Zinn, Caleb; Lamar, Duncan; Singeltary, Emily; Siegel, Lauren; Kallmes, David F; Arthur, Adam S; Gellissen, Susanne; Fiehler, Jens; Heit, Jeremy J.
in: J NEUROINTERV SURG, Jahrgang 14, Nr. 10, 10.2022, S. 1027-1032.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Common data elements reported on middle meningeal artery embolization in chronic subdural hematoma: an interactive systematic review of recent trials
AU - Adusumilli, Gautam
AU - Ghozy, Sherief
AU - Kallmes, Kevin M
AU - Hardy, Nicole
AU - Tarchand, Ranita
AU - Zinn, Caleb
AU - Lamar, Duncan
AU - Singeltary, Emily
AU - Siegel, Lauren
AU - Kallmes, David F
AU - Arthur, Adam S
AU - Gellissen, Susanne
AU - Fiehler, Jens
AU - Heit, Jeremy J
N1 - © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2022/10
Y1 - 2022/10
N2 - Cross study heterogeneity has limited the evidence based evaluation of middle meningeal artery embolization (MMAE) as a treatment for chronic subdural hematoma (CSDH). Ongoing trials and prospective studies suggest that heterogeneity in upcoming publications may detract from subsequent meta-analyses and systemic reviews. This study aims to describe this data heterogeneity to promote harmonization with common data elements (CDEs) in publications. ClinicalTrials.gov and PubMed were searched for published or ongoing prospective trials of MMAE. The Nested Knowledge AutoLit living review platform was utilized to classify endpoints from randomized control trials (RCTs) and prospective cohort studies comparing MMAE with other treatments. The qualitative synthesis feature was used to determine cross study overlap of outcome related data elements. Eighteen studies were included: 12 RCTs, two non-randomized controlled studies, two prospective single arm trials, one combined prospective and retrospective controlled study, and one prospective cohort study. The most commonly reported data element was recurrence (15/18), but seven heterogenous (non-comparable) definitions were used for 'recurrence'. Mortality was reported in 10/18 studies, but no common timepoint was reported in more than four studies. Re-intervention and CSDH volume were reported in eight studies, CSDH width in seven, and no other outcome was common across more than five studies. There was significant heterogeneity in data element collection even among prospective registered trials of MMAE. Even among CDEs, variation in definition and timepoints prevented harmonization. A standardized approach based on CDEs may be necessary to facilitate future meta-analyses and evidence driven evaluation of MMAE treatment of CSDH.
AB - Cross study heterogeneity has limited the evidence based evaluation of middle meningeal artery embolization (MMAE) as a treatment for chronic subdural hematoma (CSDH). Ongoing trials and prospective studies suggest that heterogeneity in upcoming publications may detract from subsequent meta-analyses and systemic reviews. This study aims to describe this data heterogeneity to promote harmonization with common data elements (CDEs) in publications. ClinicalTrials.gov and PubMed were searched for published or ongoing prospective trials of MMAE. The Nested Knowledge AutoLit living review platform was utilized to classify endpoints from randomized control trials (RCTs) and prospective cohort studies comparing MMAE with other treatments. The qualitative synthesis feature was used to determine cross study overlap of outcome related data elements. Eighteen studies were included: 12 RCTs, two non-randomized controlled studies, two prospective single arm trials, one combined prospective and retrospective controlled study, and one prospective cohort study. The most commonly reported data element was recurrence (15/18), but seven heterogenous (non-comparable) definitions were used for 'recurrence'. Mortality was reported in 10/18 studies, but no common timepoint was reported in more than four studies. Re-intervention and CSDH volume were reported in eight studies, CSDH width in seven, and no other outcome was common across more than five studies. There was significant heterogeneity in data element collection even among prospective registered trials of MMAE. Even among CDEs, variation in definition and timepoints prevented harmonization. A standardized approach based on CDEs may be necessary to facilitate future meta-analyses and evidence driven evaluation of MMAE treatment of CSDH.
KW - Common Data Elements
KW - Embolization, Therapeutic
KW - Hematoma, Subdural, Chronic/diagnostic imaging
KW - Humans
KW - Meningeal Arteries/diagnostic imaging
KW - Prospective Studies
U2 - 10.1136/neurintsurg-2021-018430
DO - 10.1136/neurintsurg-2021-018430
M3 - SCORING: Review article
C2 - 35135849
VL - 14
SP - 1027
EP - 1032
JO - J NEUROINTERV SURG
JF - J NEUROINTERV SURG
SN - 1759-8478
IS - 10
ER -