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Combined ramR mutation and presence of a Tn1721-associated tet(A) variant in a clinical isolate of Salmonella enterica Serovar Hadar resistant to Tigecycline.

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Combined ramR mutation and presence of a Tn1721-associated tet(A) variant in a clinical isolate of Salmonella enterica Serovar Hadar resistant to Tigecycline. / Hentschke, Moritz; Christner, Martin; Sobottka, Ingo; Aepfelbacher, Martin; Rohde, Holger.

in: ANTIMICROB AGENTS CH, 2009.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hentschke, M, Christner, M, Sobottka, I, Aepfelbacher, M & Rohde, H 2009, 'Combined ramR mutation and presence of a Tn1721-associated tet(A) variant in a clinical isolate of Salmonella enterica Serovar Hadar resistant to Tigecycline.', ANTIMICROB AGENTS CH. <http://www.ncbi.nlm.nih.gov/pubmed/20028818?dopt=Citation>

APA

Hentschke, M., Christner, M., Sobottka, I., Aepfelbacher, M., & Rohde, H. (2009). Combined ramR mutation and presence of a Tn1721-associated tet(A) variant in a clinical isolate of Salmonella enterica Serovar Hadar resistant to Tigecycline. ANTIMICROB AGENTS CH. http://www.ncbi.nlm.nih.gov/pubmed/20028818?dopt=Citation

Vancouver

Hentschke M, Christner M, Sobottka I, Aepfelbacher M, Rohde H. Combined ramR mutation and presence of a Tn1721-associated tet(A) variant in a clinical isolate of Salmonella enterica Serovar Hadar resistant to Tigecycline. ANTIMICROB AGENTS CH. 2009.

Bibtex

@article{db40c26e0f9b459eb41c356a3ee6ffcb,
title = "Combined ramR mutation and presence of a Tn1721-associated tet(A) variant in a clinical isolate of Salmonella enterica Serovar Hadar resistant to Tigecycline.",
abstract = "A Salmonella enterica Serovar Hadar strain resistant to tigecycline (MIC 16 mug/ml) was isolated. Molecular characterization revealed the presence of a plasmid-borne tet(A) variant associated with Tn1721 mediating a rise of the MIC for tigecycline when transferred to Escherichia coli. Additionally, a truncating mutation in ramR was detected. Transformation with wildtype ramR but not with the mutated ramR lowered the MIC for tigecycline. Characterization of this Salmonella isolate thus implicates ramR in resistance to tigecycline.",
author = "Moritz Hentschke and Martin Christner and Ingo Sobottka and Martin Aepfelbacher and Holger Rohde",
year = "2009",
language = "Deutsch",
journal = "ANTIMICROB AGENTS CH",
issn = "0066-4804",
publisher = "American Society for Microbiology",

}

RIS

TY - JOUR

T1 - Combined ramR mutation and presence of a Tn1721-associated tet(A) variant in a clinical isolate of Salmonella enterica Serovar Hadar resistant to Tigecycline.

AU - Hentschke, Moritz

AU - Christner, Martin

AU - Sobottka, Ingo

AU - Aepfelbacher, Martin

AU - Rohde, Holger

PY - 2009

Y1 - 2009

N2 - A Salmonella enterica Serovar Hadar strain resistant to tigecycline (MIC 16 mug/ml) was isolated. Molecular characterization revealed the presence of a plasmid-borne tet(A) variant associated with Tn1721 mediating a rise of the MIC for tigecycline when transferred to Escherichia coli. Additionally, a truncating mutation in ramR was detected. Transformation with wildtype ramR but not with the mutated ramR lowered the MIC for tigecycline. Characterization of this Salmonella isolate thus implicates ramR in resistance to tigecycline.

AB - A Salmonella enterica Serovar Hadar strain resistant to tigecycline (MIC 16 mug/ml) was isolated. Molecular characterization revealed the presence of a plasmid-borne tet(A) variant associated with Tn1721 mediating a rise of the MIC for tigecycline when transferred to Escherichia coli. Additionally, a truncating mutation in ramR was detected. Transformation with wildtype ramR but not with the mutated ramR lowered the MIC for tigecycline. Characterization of this Salmonella isolate thus implicates ramR in resistance to tigecycline.

M3 - SCORING: Zeitschriftenaufsatz

JO - ANTIMICROB AGENTS CH

JF - ANTIMICROB AGENTS CH

SN - 0066-4804

ER -