Combined Preclinical Magnetic Particle Imaging and Magnetic Resonance Imaging: Initial Results in Mice
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Combined Preclinical Magnetic Particle Imaging and Magnetic Resonance Imaging: Initial Results in Mice. / Kaul, M G; Weber, O; Heinen, U; Reitmeier, A; Mummert, T; Jung, C; Raabe, N; Knopp, T; Ittrich, H; Adam, G.
in: ROFO-FORTSCHR RONTG, Jahrgang 187, Nr. 5, 05.2015, S. 347-52.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Combined Preclinical Magnetic Particle Imaging and Magnetic Resonance Imaging: Initial Results in Mice
AU - Kaul, M G
AU - Weber, O
AU - Heinen, U
AU - Reitmeier, A
AU - Mummert, T
AU - Jung, C
AU - Raabe, N
AU - Knopp, T
AU - Ittrich, H
AU - Adam, G
N1 - © Georg Thieme Verlag KG Stuttgart · New York.
PY - 2015/5
Y1 - 2015/5
N2 - PURPOSE: Magnetic particle imaging (MPI) is a new radiologic imaging modality. For the first time, a commercial preclinical scanner is installed. The goal of this study was to establish a workflow between MPI and magnetic resonance imaging (MRI) scanners for a complete in vivo examination of a mouse and to generate the first co-registered in vivo MR-MP images.MATERIALS AND METHODS: The in vivo examination of five mice were performed on a preclinical MPI scanner and a 7 Tesla preclinical MRI system. MRI measurements were used for anatomical referencing and validation of the injection of superparamagnetic iron oxide (SPIO) particles during a dynamic MPI scan. We extracted MPI data of the injection phase and co-registered it with MRI data.RESULTS: A workflow process for a combined in vivo MRI and MPI examination was established. A successful injection of ferucarbotran was proven in MPI and MRI. MR-MPI co-registration allocated the SPIOs in the inferior vena cava and the heart during and shortly after the injection.CONCLUSION: The acquisition of preclinical MPI and MRI data is feasible and allows the combined analysis of MR-MPI information.
AB - PURPOSE: Magnetic particle imaging (MPI) is a new radiologic imaging modality. For the first time, a commercial preclinical scanner is installed. The goal of this study was to establish a workflow between MPI and magnetic resonance imaging (MRI) scanners for a complete in vivo examination of a mouse and to generate the first co-registered in vivo MR-MP images.MATERIALS AND METHODS: The in vivo examination of five mice were performed on a preclinical MPI scanner and a 7 Tesla preclinical MRI system. MRI measurements were used for anatomical referencing and validation of the injection of superparamagnetic iron oxide (SPIO) particles during a dynamic MPI scan. We extracted MPI data of the injection phase and co-registered it with MRI data.RESULTS: A workflow process for a combined in vivo MRI and MPI examination was established. A successful injection of ferucarbotran was proven in MPI and MRI. MR-MPI co-registration allocated the SPIOs in the inferior vena cava and the heart during and shortly after the injection.CONCLUSION: The acquisition of preclinical MPI and MRI data is feasible and allows the combined analysis of MR-MPI information.
KW - Animals
KW - Blood Flow Velocity
KW - Dextrans
KW - Image Enhancement
KW - Image Interpretation, Computer-Assisted
KW - Magnetic Resonance Angiography
KW - Magnetite Nanoparticles
KW - Mice
KW - Multimodal Imaging
KW - Pilot Projects
KW - Reproducibility of Results
KW - Sensitivity and Specificity
KW - Subtraction Technique
KW - Vena Cava, Inferior
KW - Workflow
U2 - 10.1055/s-0034-1399344
DO - 10.1055/s-0034-1399344
M3 - SCORING: Journal article
C2 - 25962671
VL - 187
SP - 347
EP - 352
JO - ROFO-FORTSCHR RONTG
JF - ROFO-FORTSCHR RONTG
SN - 1438-9029
IS - 5
ER -
