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Combined gadoxetic acid and gadofosveset enhanced liver MRI: A feasibility and parameter optimization study

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Combined gadoxetic acid and gadofosveset enhanced liver MRI: A feasibility and parameter optimization study. / Bannas, Peter; Motosugi, Utaroh; Hernando, Diego; Rahimi, Mahdi Salmani; Holmes, James H; Reeder, Scott B.

in: MAGN RESON MED, Jahrgang 75, Nr. 1, 01.2016, S. 318-28.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bannas, P, Motosugi, U, Hernando, D, Rahimi, MS, Holmes, JH & Reeder, SB 2016, 'Combined gadoxetic acid and gadofosveset enhanced liver MRI: A feasibility and parameter optimization study', MAGN RESON MED, Jg. 75, Nr. 1, S. 318-28. https://doi.org/10.1002/mrm.25554

APA

Bannas, P., Motosugi, U., Hernando, D., Rahimi, M. S., Holmes, J. H., & Reeder, S. B. (2016). Combined gadoxetic acid and gadofosveset enhanced liver MRI: A feasibility and parameter optimization study. MAGN RESON MED, 75(1), 318-28. https://doi.org/10.1002/mrm.25554

Vancouver

Bannas P, Motosugi U, Hernando D, Rahimi MS, Holmes JH, Reeder SB. Combined gadoxetic acid and gadofosveset enhanced liver MRI: A feasibility and parameter optimization study. MAGN RESON MED. 2016 Jan;75(1):318-28. https://doi.org/10.1002/mrm.25554

Bibtex

@article{92a72c78c1aa4508974a6995aff985e4,
title = "Combined gadoxetic acid and gadofosveset enhanced liver MRI: A feasibility and parameter optimization study",
abstract = "PURPOSE: Demonstration of feasibility and protocol optimization for the combined use of gadofosveset trisodium with gadoxetic acid for delayed T1-weighted liver MRI.METHODS: Eleven healthy volunteers underwent hepatobiliary phase imaging at 3 Tesla (T) using gadoxetic acid. Multiple breathheld T1-weighted three-dimensional spoiled gradient echo sequences were performed at varying flip angles before and after injection of gadofosveset. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were measured to determine optimal T1-weighting. Examples of three patients with focal liver lesions were acquired.RESULTS: The addition of gadofosveset to the hepatobiliary phase of gadoxetic acid renders vessels isointense to liver tissue at low flip angles due to increased vessel SNR (P < 0.001). The lowest CNR of liver relative to portal vein (CNR = 15; 95% confidence interval [CI]: -14-44) was observed at a 10º flip angle. The highest CNR of liver relative to muscle (CNR = 214; 95% CI: 191-237) was observed at a 20º flip angle. The combined enhancement leads to homogenously enhanced liver tissue and liver vasculature. Cysts were detected in three volunteers and metastases were detected in two patients. In these anecdotal cases the cysts and metastases stood out as conspicuous focal hypointensities on combined gadoxetic acid and gadofosveset enhanced images.CONCLUSION: Combined gadoxetic acid and gadofosveset enhanced liver MRI is feasible, with low flip angles minimizing contrast between vessels and liver. Further clinical studies are needed to confirm that low flip angles provide an optimal combination of sensitivity and specificity for lesion detection in patients.",
keywords = "Adult, Contrast Media, Drug Combinations, Drug Synergism, Feasibility Studies, Female, Gadolinium, Gadolinium DTPA, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Imaging, Three-Dimensional, Liver, Liver Neoplasms, Magnetic Resonance Imaging, Male, Middle Aged, Organometallic Compounds, Reproducibility of Results, Sensitivity and Specificity, Young Adult, Journal Article, Research Support, Non-U.S. Gov't",
author = "Peter Bannas and Utaroh Motosugi and Diego Hernando and Rahimi, {Mahdi Salmani} and Holmes, {James H} and Reeder, {Scott B}",
note = "{\textcopyright} 2015 Wiley Periodicals, Inc.",
year = "2016",
month = jan,
doi = "10.1002/mrm.25554",
language = "English",
volume = "75",
pages = "318--28",
journal = "MAGN RESON MED",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Combined gadoxetic acid and gadofosveset enhanced liver MRI: A feasibility and parameter optimization study

AU - Bannas, Peter

AU - Motosugi, Utaroh

AU - Hernando, Diego

AU - Rahimi, Mahdi Salmani

AU - Holmes, James H

AU - Reeder, Scott B

N1 - © 2015 Wiley Periodicals, Inc.

PY - 2016/1

Y1 - 2016/1

N2 - PURPOSE: Demonstration of feasibility and protocol optimization for the combined use of gadofosveset trisodium with gadoxetic acid for delayed T1-weighted liver MRI.METHODS: Eleven healthy volunteers underwent hepatobiliary phase imaging at 3 Tesla (T) using gadoxetic acid. Multiple breathheld T1-weighted three-dimensional spoiled gradient echo sequences were performed at varying flip angles before and after injection of gadofosveset. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were measured to determine optimal T1-weighting. Examples of three patients with focal liver lesions were acquired.RESULTS: The addition of gadofosveset to the hepatobiliary phase of gadoxetic acid renders vessels isointense to liver tissue at low flip angles due to increased vessel SNR (P < 0.001). The lowest CNR of liver relative to portal vein (CNR = 15; 95% confidence interval [CI]: -14-44) was observed at a 10º flip angle. The highest CNR of liver relative to muscle (CNR = 214; 95% CI: 191-237) was observed at a 20º flip angle. The combined enhancement leads to homogenously enhanced liver tissue and liver vasculature. Cysts were detected in three volunteers and metastases were detected in two patients. In these anecdotal cases the cysts and metastases stood out as conspicuous focal hypointensities on combined gadoxetic acid and gadofosveset enhanced images.CONCLUSION: Combined gadoxetic acid and gadofosveset enhanced liver MRI is feasible, with low flip angles minimizing contrast between vessels and liver. Further clinical studies are needed to confirm that low flip angles provide an optimal combination of sensitivity and specificity for lesion detection in patients.

AB - PURPOSE: Demonstration of feasibility and protocol optimization for the combined use of gadofosveset trisodium with gadoxetic acid for delayed T1-weighted liver MRI.METHODS: Eleven healthy volunteers underwent hepatobiliary phase imaging at 3 Tesla (T) using gadoxetic acid. Multiple breathheld T1-weighted three-dimensional spoiled gradient echo sequences were performed at varying flip angles before and after injection of gadofosveset. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were measured to determine optimal T1-weighting. Examples of three patients with focal liver lesions were acquired.RESULTS: The addition of gadofosveset to the hepatobiliary phase of gadoxetic acid renders vessels isointense to liver tissue at low flip angles due to increased vessel SNR (P < 0.001). The lowest CNR of liver relative to portal vein (CNR = 15; 95% confidence interval [CI]: -14-44) was observed at a 10º flip angle. The highest CNR of liver relative to muscle (CNR = 214; 95% CI: 191-237) was observed at a 20º flip angle. The combined enhancement leads to homogenously enhanced liver tissue and liver vasculature. Cysts were detected in three volunteers and metastases were detected in two patients. In these anecdotal cases the cysts and metastases stood out as conspicuous focal hypointensities on combined gadoxetic acid and gadofosveset enhanced images.CONCLUSION: Combined gadoxetic acid and gadofosveset enhanced liver MRI is feasible, with low flip angles minimizing contrast between vessels and liver. Further clinical studies are needed to confirm that low flip angles provide an optimal combination of sensitivity and specificity for lesion detection in patients.

KW - Adult

KW - Contrast Media

KW - Drug Combinations

KW - Drug Synergism

KW - Feasibility Studies

KW - Female

KW - Gadolinium

KW - Gadolinium DTPA

KW - Humans

KW - Image Enhancement

KW - Image Interpretation, Computer-Assisted

KW - Imaging, Three-Dimensional

KW - Liver

KW - Liver Neoplasms

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Organometallic Compounds

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Young Adult

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/mrm.25554

DO - 10.1002/mrm.25554

M3 - SCORING: Journal article

C2 - 25648403

VL - 75

SP - 318

EP - 328

JO - MAGN RESON MED

JF - MAGN RESON MED

SN - 0740-3194

IS - 1

ER -