Combined associations of a polygenic risk score and classical risk factors with breast cancer risk
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Combined associations of a polygenic risk score and classical risk factors with breast cancer risk. / Kapoor, Pooja Middha; Mavaddat, Nasim; Choudhury, Parichoy Pal; Wilcox, Amber N; Lindström, Sara; Behrens, Sabine; Michailidou, Kyriaki; Dennis, Joe; Bolla, Manjeet K; Wang, Qin; Jung, Audrey; Abu-Ful, Zomoroda; Ahearn, Thomas; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Aronson, Kristan J; Auer, Paul L; Freeman, Laura E Beane; Becher, Heiko; Beeghly-Fadiel, Alicia; Benitez, Javier; Bernstein, Leslie; Bojesen, Stig E; Brauch, Hiltrud; Brenner, Hermann; Brüning, Thomas; Cai, Qiuyin; Campa, Daniele; Canzian, Federico; Carracedo, Angel; Carter, Brian D; Castelao, Jose E; Chanock, Stephen J; Chatterjee, Nilanjan; Chenevix-Trench, Georgia; Clarke, Christine L; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Dai, James Y; Earp, H Shelton; Ekici, Arif B; Eliassen, A Heather; Eriksson, Mikael; Evans, D Gareth; Fasching, Peter A; Figueroa, Jonine; Fritschi, Lin; Gabrielson, Marike; Gago-Dominguez, Manuela; Gao, Chi; Gapstur, Susan M; Gaudet, Mia M; Giles, Graham G; González-Neira, Anna; Guénel, Pascal; Haeberle, Lothar; Haiman, Christopher A; Håkansson, Niclas; Hall, Per; Hamann, Ute; Hatse, Sigrid; Heyworth, Jane; Holleczek, Bernd; Hoover, Robert N; Hopper, John L; Howell, Anthony; Hunter, David J; John, Esther M; Jones, Michael E; Kaaks, Rudolf; Keeman, Renske; Kitahara, Cari M; Ko, Yon-Dschun; Koutros, Stella; Kurian, Allison W; Lambrechts, Diether; Marchand, Loic Le; Lee, Eunjung; Lejbkowicz, Flavio; Linet, Martha; Lissowska, Jolanta; Llaneza, Ana; MacInnis, Robert J; Martinez, Maria Elena; Maurer, Tabea; McLean, Catriona; Neuhausen, Susan L; Newman, William G; Norman, Aaron; O'Brien, Katie M; Olshan, Andrew F; Olson, Janet E; Olsson, Håkan; Orr, Nick; Perou, Charles M; Pita, Guillermo; Polley, Eric C; Prentice, Ross L; Rennert, Gad; Rennert, Hedy S; Ruddy, Kathryn J; Sandler, Dale P; Saunders, Christobel; Schoemaker, Minouk J; Schöttker, Ben; Schumacher, Fredrick; Scott, Christopher; Scott, Rodney J; Shu, Xiao-Ou; Smeets, Ann; Southey, Melissa C; Spinelli, John J; Stone, Jennifer; Swerdlow, Anthony J; Tamimi, Rulla M; Taylor, Jack A; Troester, Melissa A; Vachon, Celine M; van Veen, Elke M; Wang, Xiaoliang; Weinberg, Clarice R; Weltens, Caroline; Willett, Walter; Winham, Stacey J; Wolk, Alicja; Yang, Xiaohong R; Zheng, Wei; Ziogas, Argyrios; Dunning, Alison M; Pharoah, Paul D P; Schmidt, Marjanka K; Kraft, Peter; Easton, Douglas F; Milne, Roger L; García-Closas, Montserrat; Chang-Claude, Jenny; ABCTB Investigators.
in: JNCI-J NATL CANCER I, Jahrgang 113, Nr. 3, 01.03.2021, S. 329-337.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Combined associations of a polygenic risk score and classical risk factors with breast cancer risk
AU - Kapoor, Pooja Middha
AU - Mavaddat, Nasim
AU - Choudhury, Parichoy Pal
AU - Wilcox, Amber N
AU - Lindström, Sara
AU - Behrens, Sabine
AU - Michailidou, Kyriaki
AU - Dennis, Joe
AU - Bolla, Manjeet K
AU - Wang, Qin
AU - Jung, Audrey
AU - Abu-Ful, Zomoroda
AU - Ahearn, Thomas
AU - Andrulis, Irene L
AU - Anton-Culver, Hoda
AU - Arndt, Volker
AU - Aronson, Kristan J
AU - Auer, Paul L
AU - Freeman, Laura E Beane
AU - Becher, Heiko
AU - Beeghly-Fadiel, Alicia
AU - Benitez, Javier
AU - Bernstein, Leslie
AU - Bojesen, Stig E
AU - Brauch, Hiltrud
AU - Brenner, Hermann
AU - Brüning, Thomas
AU - Cai, Qiuyin
AU - Campa, Daniele
AU - Canzian, Federico
AU - Carracedo, Angel
AU - Carter, Brian D
AU - Castelao, Jose E
AU - Chanock, Stephen J
AU - Chatterjee, Nilanjan
AU - Chenevix-Trench, Georgia
AU - Clarke, Christine L
AU - Couch, Fergus J
AU - Cox, Angela
AU - Cross, Simon S
AU - Czene, Kamila
AU - Dai, James Y
AU - Earp, H Shelton
AU - Ekici, Arif B
AU - Eliassen, A Heather
AU - Eriksson, Mikael
AU - Evans, D Gareth
AU - Fasching, Peter A
AU - Figueroa, Jonine
AU - Fritschi, Lin
AU - Gabrielson, Marike
AU - Gago-Dominguez, Manuela
AU - Gao, Chi
AU - Gapstur, Susan M
AU - Gaudet, Mia M
AU - Giles, Graham G
AU - González-Neira, Anna
AU - Guénel, Pascal
AU - Haeberle, Lothar
AU - Haiman, Christopher A
AU - Håkansson, Niclas
AU - Hall, Per
AU - Hamann, Ute
AU - Hatse, Sigrid
AU - Heyworth, Jane
AU - Holleczek, Bernd
AU - Hoover, Robert N
AU - Hopper, John L
AU - Howell, Anthony
AU - Hunter, David J
AU - John, Esther M
AU - Jones, Michael E
AU - Kaaks, Rudolf
AU - Keeman, Renske
AU - Kitahara, Cari M
AU - Ko, Yon-Dschun
AU - Koutros, Stella
AU - Kurian, Allison W
AU - Lambrechts, Diether
AU - Marchand, Loic Le
AU - Lee, Eunjung
AU - Lejbkowicz, Flavio
AU - Linet, Martha
AU - Lissowska, Jolanta
AU - Llaneza, Ana
AU - MacInnis, Robert J
AU - Martinez, Maria Elena
AU - Maurer, Tabea
AU - McLean, Catriona
AU - Neuhausen, Susan L
AU - Newman, William G
AU - Norman, Aaron
AU - O'Brien, Katie M
AU - Olshan, Andrew F
AU - Olson, Janet E
AU - Olsson, Håkan
AU - Orr, Nick
AU - Perou, Charles M
AU - Pita, Guillermo
AU - Polley, Eric C
AU - Prentice, Ross L
AU - Rennert, Gad
AU - Rennert, Hedy S
AU - Ruddy, Kathryn J
AU - Sandler, Dale P
AU - Saunders, Christobel
AU - Schoemaker, Minouk J
AU - Schöttker, Ben
AU - Schumacher, Fredrick
AU - Scott, Christopher
AU - Scott, Rodney J
AU - Shu, Xiao-Ou
AU - Smeets, Ann
AU - Southey, Melissa C
AU - Spinelli, John J
AU - Stone, Jennifer
AU - Swerdlow, Anthony J
AU - Tamimi, Rulla M
AU - Taylor, Jack A
AU - Troester, Melissa A
AU - Vachon, Celine M
AU - van Veen, Elke M
AU - Wang, Xiaoliang
AU - Weinberg, Clarice R
AU - Weltens, Caroline
AU - Willett, Walter
AU - Winham, Stacey J
AU - Wolk, Alicja
AU - Yang, Xiaohong R
AU - Zheng, Wei
AU - Ziogas, Argyrios
AU - Dunning, Alison M
AU - Pharoah, Paul D P
AU - Schmidt, Marjanka K
AU - Kraft, Peter
AU - Easton, Douglas F
AU - Milne, Roger L
AU - García-Closas, Montserrat
AU - Chang-Claude, Jenny
AU - ABCTB Investigators
N1 - © The Author(s) 2020. Published by Oxford University Press.
PY - 2021/3/1
Y1 - 2021/3/1
N2 - We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72,284 cases and 80,354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression, and a newly developed case-only method, for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history), and on average 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer.
AB - We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72,284 cases and 80,354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression, and a newly developed case-only method, for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history), and on average 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer.
U2 - 10.1093/jnci/djaa056
DO - 10.1093/jnci/djaa056
M3 - SCORING: Journal article
C2 - 32359158
VL - 113
SP - 329
EP - 337
JO - JNCI-J NATL CANCER I
JF - JNCI-J NATL CANCER I
SN - 0027-8874
IS - 3
ER -