Combination of multiple molecular markers can improve prognostication in patients with locally advanced and lymph node positive bladder cancer.
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Combination of multiple molecular markers can improve prognostication in patients with locally advanced and lymph node positive bladder cancer. / Shariat, Shahrokh F; Chade Daher, C; Karakiewicz, Pierre I; Ashfaq, Raheela; Isbarn, Hendrik; Fradet, Yves; Bastian, Patrick J; Nielsen, Matthew E; Capitanio, Umberto; Jeldres, Claudio; Montorsi, Francesco; Lerner, Seth P; Sagalowsky, Arthur I; Cote, Richard J; Lotan, Yair.
in: J UROLOGY, Jahrgang 183, Nr. 1, 1, 2010, S. 68-75.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Combination of multiple molecular markers can improve prognostication in patients with locally advanced and lymph node positive bladder cancer.
AU - Shariat, Shahrokh F
AU - Chade Daher, C
AU - Karakiewicz, Pierre I
AU - Ashfaq, Raheela
AU - Isbarn, Hendrik
AU - Fradet, Yves
AU - Bastian, Patrick J
AU - Nielsen, Matthew E
AU - Capitanio, Umberto
AU - Jeldres, Claudio
AU - Montorsi, Francesco
AU - Lerner, Seth P
AU - Sagalowsky, Arthur I
AU - Cote, Richard J
AU - Lotan, Yair
PY - 2010
Y1 - 2010
N2 - PURPOSE: We tested whether the combination of 4 established cell cycle regulators (p53, pRB, p21 and p27) could improve the ability to predict clinical outcomes in a large multi-institutional collaboration of patients with pT3-4N0 or pTany Npositive urothelial carcinoma of the bladder. We also assessed whether the combination of molecular markers is superior to any individual biomarker. MATERIALS AND METHODS: The study comprised 692 patients with pT3-4N0 or pTany Npositive urothelial carcinoma of the bladder treated with radical cystectomy and bilateral lymphadenectomy (median followup 5.3 years). Scoring was performed using advanced cell imaging and color detection software. The base model incorporated patient age, gender, stage, grade, lymphovascular invasion, number of lymph nodes removed, number of positive lymph nodes, concomitant carcinoma in situ and adjuvant chemotherapy. RESULTS: Individual molecular markers did not improve the predictive accuracy for disease recurrence and cancer specific mortality. Combination of all 4 molecular markers into number of altered molecular markers resulted in significantly higher predictive accuracy than any single biomarker (p
AB - PURPOSE: We tested whether the combination of 4 established cell cycle regulators (p53, pRB, p21 and p27) could improve the ability to predict clinical outcomes in a large multi-institutional collaboration of patients with pT3-4N0 or pTany Npositive urothelial carcinoma of the bladder. We also assessed whether the combination of molecular markers is superior to any individual biomarker. MATERIALS AND METHODS: The study comprised 692 patients with pT3-4N0 or pTany Npositive urothelial carcinoma of the bladder treated with radical cystectomy and bilateral lymphadenectomy (median followup 5.3 years). Scoring was performed using advanced cell imaging and color detection software. The base model incorporated patient age, gender, stage, grade, lymphovascular invasion, number of lymph nodes removed, number of positive lymph nodes, concomitant carcinoma in situ and adjuvant chemotherapy. RESULTS: Individual molecular markers did not improve the predictive accuracy for disease recurrence and cancer specific mortality. Combination of all 4 molecular markers into number of altered molecular markers resulted in significantly higher predictive accuracy than any single biomarker (p
M3 - SCORING: Zeitschriftenaufsatz
VL - 183
SP - 68
EP - 75
JO - J UROLOGY
JF - J UROLOGY
SN - 0022-5347
IS - 1
M1 - 1
ER -
