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Combination of fractionated irradiation with nicotinamide and carbogen in R1H-tumours of the rat and its pulmonary metastases.

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Combination of fractionated irradiation with nicotinamide and carbogen in R1H-tumours of the rat and its pulmonary metastases. / Raabe, A; Rett, M; Krüll, Andreas; Beck-Bornholdt, Hans-Peter.

in: RADIOTHER ONCOL, Jahrgang 45, Nr. 2, 2, 1997, S. 183-189.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Raabe, A, Rett, M, Krüll, A & Beck-Bornholdt, H-P 1997, 'Combination of fractionated irradiation with nicotinamide and carbogen in R1H-tumours of the rat and its pulmonary metastases.', RADIOTHER ONCOL, Jg. 45, Nr. 2, 2, S. 183-189. <http://www.ncbi.nlm.nih.gov/pubmed/9424010?dopt=Citation>

APA

Raabe, A., Rett, M., Krüll, A., & Beck-Bornholdt, H-P. (1997). Combination of fractionated irradiation with nicotinamide and carbogen in R1H-tumours of the rat and its pulmonary metastases. RADIOTHER ONCOL, 45(2), 183-189. [2]. http://www.ncbi.nlm.nih.gov/pubmed/9424010?dopt=Citation

Vancouver

Raabe A, Rett M, Krüll A, Beck-Bornholdt H-P. Combination of fractionated irradiation with nicotinamide and carbogen in R1H-tumours of the rat and its pulmonary metastases. RADIOTHER ONCOL. 1997;45(2):183-189. 2.

Bibtex

@article{128c4f64812e453f9d3e54ecb5a17d58,
title = "Combination of fractionated irradiation with nicotinamide and carbogen in R1H-tumours of the rat and its pulmonary metastases.",
abstract = "BACKGROUND AND PURPOSE: The combination of radiotherapy with nicotinamide and carbogen is a promising method to improve treatment outcome. The aim of the present study was to investigate its effect on rat lungs, the R1H-tumour and its pulmonary metastases. MATERIALS AND METHODS: Subcutaneous tumours and artificially induced pulmonary metastases of the rhabdomyosarcoma R1H of the rat were treated either with fractionated irradiation alone or in combination with nicotinamide and carbogen. Local metastatic control, net growth delay and lethal lung damage were used as endpoints. RESULTS: Radiosensitivity of the lungs of WAG/Rij rats increased by a factor of 1.13, while no positive effect of the combined treatment either on subcutaneous R1H-tumours or on pulmonary metastases could be detected. This resulted in a therapeutic loss of 18% (P = 0.003). CONCLUSION: The results indicate that deleterious effects of the combination of radiotherapy with nicotinamide and carbogen cannot be excluded under all circumstances.",
author = "A Raabe and M Rett and Andreas Kr{\"u}ll and Hans-Peter Beck-Bornholdt",
year = "1997",
language = "Deutsch",
volume = "45",
pages = "183--189",
journal = "RADIOTHER ONCOL",
issn = "0167-8140",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Combination of fractionated irradiation with nicotinamide and carbogen in R1H-tumours of the rat and its pulmonary metastases.

AU - Raabe, A

AU - Rett, M

AU - Krüll, Andreas

AU - Beck-Bornholdt, Hans-Peter

PY - 1997

Y1 - 1997

N2 - BACKGROUND AND PURPOSE: The combination of radiotherapy with nicotinamide and carbogen is a promising method to improve treatment outcome. The aim of the present study was to investigate its effect on rat lungs, the R1H-tumour and its pulmonary metastases. MATERIALS AND METHODS: Subcutaneous tumours and artificially induced pulmonary metastases of the rhabdomyosarcoma R1H of the rat were treated either with fractionated irradiation alone or in combination with nicotinamide and carbogen. Local metastatic control, net growth delay and lethal lung damage were used as endpoints. RESULTS: Radiosensitivity of the lungs of WAG/Rij rats increased by a factor of 1.13, while no positive effect of the combined treatment either on subcutaneous R1H-tumours or on pulmonary metastases could be detected. This resulted in a therapeutic loss of 18% (P = 0.003). CONCLUSION: The results indicate that deleterious effects of the combination of radiotherapy with nicotinamide and carbogen cannot be excluded under all circumstances.

AB - BACKGROUND AND PURPOSE: The combination of radiotherapy with nicotinamide and carbogen is a promising method to improve treatment outcome. The aim of the present study was to investigate its effect on rat lungs, the R1H-tumour and its pulmonary metastases. MATERIALS AND METHODS: Subcutaneous tumours and artificially induced pulmonary metastases of the rhabdomyosarcoma R1H of the rat were treated either with fractionated irradiation alone or in combination with nicotinamide and carbogen. Local metastatic control, net growth delay and lethal lung damage were used as endpoints. RESULTS: Radiosensitivity of the lungs of WAG/Rij rats increased by a factor of 1.13, while no positive effect of the combined treatment either on subcutaneous R1H-tumours or on pulmonary metastases could be detected. This resulted in a therapeutic loss of 18% (P = 0.003). CONCLUSION: The results indicate that deleterious effects of the combination of radiotherapy with nicotinamide and carbogen cannot be excluded under all circumstances.

M3 - SCORING: Zeitschriftenaufsatz

VL - 45

SP - 183

EP - 189

JO - RADIOTHER ONCOL

JF - RADIOTHER ONCOL

SN - 0167-8140

IS - 2

M1 - 2

ER -