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Cold-Induced Brown Adipose Tissue Activity Alters Plasma Fatty Acids and Improves Glucose Metabolism in Men

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Cold-Induced Brown Adipose Tissue Activity Alters Plasma Fatty Acids and Improves Glucose Metabolism in Men. / Iwen, K Alexander; Backhaus, Jenny; Cassens, Melanie; Waltl, Maren; Hedesan, Oana C; Merkel, Martin; Heeren, Joerg; Sina, Christian; Rademacher, Leonie; Windjäger, Anne; Haug, Alexander R; Kiefer, Florian W; Lehnert, Hendrik; Schmid, Sebastian M.

in: J CLIN ENDOCR METAB, Jahrgang 102, Nr. 11, 01.11.2017, S. 4226-4234.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Iwen, KA, Backhaus, J, Cassens, M, Waltl, M, Hedesan, OC, Merkel, M, Heeren, J, Sina, C, Rademacher, L, Windjäger, A, Haug, AR, Kiefer, FW, Lehnert, H & Schmid, SM 2017, 'Cold-Induced Brown Adipose Tissue Activity Alters Plasma Fatty Acids and Improves Glucose Metabolism in Men', J CLIN ENDOCR METAB, Jg. 102, Nr. 11, S. 4226-4234. https://doi.org/10.1210/jc.2017-01250

APA

Iwen, K. A., Backhaus, J., Cassens, M., Waltl, M., Hedesan, O. C., Merkel, M., Heeren, J., Sina, C., Rademacher, L., Windjäger, A., Haug, A. R., Kiefer, F. W., Lehnert, H., & Schmid, S. M. (2017). Cold-Induced Brown Adipose Tissue Activity Alters Plasma Fatty Acids and Improves Glucose Metabolism in Men. J CLIN ENDOCR METAB, 102(11), 4226-4234. https://doi.org/10.1210/jc.2017-01250

Vancouver

Iwen KA, Backhaus J, Cassens M, Waltl M, Hedesan OC, Merkel M et al. Cold-Induced Brown Adipose Tissue Activity Alters Plasma Fatty Acids and Improves Glucose Metabolism in Men. J CLIN ENDOCR METAB. 2017 Nov 1;102(11):4226-4234. https://doi.org/10.1210/jc.2017-01250

Bibtex

@article{3a9b7d8a78734d47a451db278f741b10,
title = "Cold-Induced Brown Adipose Tissue Activity Alters Plasma Fatty Acids and Improves Glucose Metabolism in Men",
abstract = "Context: Mounting evidence suggests beneficial effects of brown adipose tissue (BAT) activation on glucose and lipid metabolism in humans. It is unclear whether cold-induced BAT activation affects not only insulin sensitivity but also insulin secretion. Likewise, the role in clearing circulating fatty acids (FAs) has not been fully explored.Objective: Exploring the effects of cold-induced BAT activation on insulin sensitivity and secretion, as well as on plasma FA profiles.Design: Fifteen healthy men participated in a cross-balanced repeated within-subject study with two experimental conditions. Subjects were exposed to thermoneutrality (22°C) and to moderate cold (18.06°C, shivering excluded) by use of a water-perfused whole body suit. Cold-induced BAT activation was quantified by [18F]-fluorodeoxyglucose positron emission tomography-computed tomography in a subset of volunteers. A Botnia clamp procedure was applied to determine pancreatic first phase insulin response (FPIR) and insulin sensitivity. Hormones and metabolites, including 26 specific plasma FAs, were sampled throughout the experiment.Results: Cold exposure induced BAT activity. Plasma noradrenaline and dopamine concentrations increased in response to cold. Peripheral glucose uptake and insulin sensitivity significantly improved by ∼20%, whereas FPIR remained stable. Lignoceric acid (C24:0) concentrations increased, whereas levels of eicosanoic acid (C20:1n9), nervonic acid (C24:1n9), and behenic acid (C22:0) decreased.Conclusions: Cold-exposure induces sympathetic nervous system activity and BAT metabolism in humans, resulting in improved glucose metabolism without affecting pancreatic insulin secretion. In addition, BAT activation is associated with altered circulating concentrations of distinct FAs. These data support the concept that human BAT metabolism significantly contributes to whole body glucose and lipid utilization in a coordinated manner.",
keywords = "Adipose Tissue, Brown, Adult, Blood Glucose, Body Temperature Regulation, Carbohydrate Metabolism, Cold Temperature, Energy Metabolism, Fatty Acids, Glucose, Humans, Insulin Resistance, Male, Thermogenesis, Clinical Trial, Journal Article",
author = "Iwen, {K Alexander} and Jenny Backhaus and Melanie Cassens and Maren Waltl and Hedesan, {Oana C} and Martin Merkel and Joerg Heeren and Christian Sina and Leonie Rademacher and Anne Windj{\"a}ger and Haug, {Alexander R} and Kiefer, {Florian W} and Hendrik Lehnert and Schmid, {Sebastian M}",
year = "2017",
month = nov,
day = "1",
doi = "10.1210/jc.2017-01250",
language = "English",
volume = "102",
pages = "4226--4234",
journal = "J CLIN ENDOCR METAB",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "11",

}

RIS

TY - JOUR

T1 - Cold-Induced Brown Adipose Tissue Activity Alters Plasma Fatty Acids and Improves Glucose Metabolism in Men

AU - Iwen, K Alexander

AU - Backhaus, Jenny

AU - Cassens, Melanie

AU - Waltl, Maren

AU - Hedesan, Oana C

AU - Merkel, Martin

AU - Heeren, Joerg

AU - Sina, Christian

AU - Rademacher, Leonie

AU - Windjäger, Anne

AU - Haug, Alexander R

AU - Kiefer, Florian W

AU - Lehnert, Hendrik

AU - Schmid, Sebastian M

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Context: Mounting evidence suggests beneficial effects of brown adipose tissue (BAT) activation on glucose and lipid metabolism in humans. It is unclear whether cold-induced BAT activation affects not only insulin sensitivity but also insulin secretion. Likewise, the role in clearing circulating fatty acids (FAs) has not been fully explored.Objective: Exploring the effects of cold-induced BAT activation on insulin sensitivity and secretion, as well as on plasma FA profiles.Design: Fifteen healthy men participated in a cross-balanced repeated within-subject study with two experimental conditions. Subjects were exposed to thermoneutrality (22°C) and to moderate cold (18.06°C, shivering excluded) by use of a water-perfused whole body suit. Cold-induced BAT activation was quantified by [18F]-fluorodeoxyglucose positron emission tomography-computed tomography in a subset of volunteers. A Botnia clamp procedure was applied to determine pancreatic first phase insulin response (FPIR) and insulin sensitivity. Hormones and metabolites, including 26 specific plasma FAs, were sampled throughout the experiment.Results: Cold exposure induced BAT activity. Plasma noradrenaline and dopamine concentrations increased in response to cold. Peripheral glucose uptake and insulin sensitivity significantly improved by ∼20%, whereas FPIR remained stable. Lignoceric acid (C24:0) concentrations increased, whereas levels of eicosanoic acid (C20:1n9), nervonic acid (C24:1n9), and behenic acid (C22:0) decreased.Conclusions: Cold-exposure induces sympathetic nervous system activity and BAT metabolism in humans, resulting in improved glucose metabolism without affecting pancreatic insulin secretion. In addition, BAT activation is associated with altered circulating concentrations of distinct FAs. These data support the concept that human BAT metabolism significantly contributes to whole body glucose and lipid utilization in a coordinated manner.

AB - Context: Mounting evidence suggests beneficial effects of brown adipose tissue (BAT) activation on glucose and lipid metabolism in humans. It is unclear whether cold-induced BAT activation affects not only insulin sensitivity but also insulin secretion. Likewise, the role in clearing circulating fatty acids (FAs) has not been fully explored.Objective: Exploring the effects of cold-induced BAT activation on insulin sensitivity and secretion, as well as on plasma FA profiles.Design: Fifteen healthy men participated in a cross-balanced repeated within-subject study with two experimental conditions. Subjects were exposed to thermoneutrality (22°C) and to moderate cold (18.06°C, shivering excluded) by use of a water-perfused whole body suit. Cold-induced BAT activation was quantified by [18F]-fluorodeoxyglucose positron emission tomography-computed tomography in a subset of volunteers. A Botnia clamp procedure was applied to determine pancreatic first phase insulin response (FPIR) and insulin sensitivity. Hormones and metabolites, including 26 specific plasma FAs, were sampled throughout the experiment.Results: Cold exposure induced BAT activity. Plasma noradrenaline and dopamine concentrations increased in response to cold. Peripheral glucose uptake and insulin sensitivity significantly improved by ∼20%, whereas FPIR remained stable. Lignoceric acid (C24:0) concentrations increased, whereas levels of eicosanoic acid (C20:1n9), nervonic acid (C24:1n9), and behenic acid (C22:0) decreased.Conclusions: Cold-exposure induces sympathetic nervous system activity and BAT metabolism in humans, resulting in improved glucose metabolism without affecting pancreatic insulin secretion. In addition, BAT activation is associated with altered circulating concentrations of distinct FAs. These data support the concept that human BAT metabolism significantly contributes to whole body glucose and lipid utilization in a coordinated manner.

KW - Adipose Tissue, Brown

KW - Adult

KW - Blood Glucose

KW - Body Temperature Regulation

KW - Carbohydrate Metabolism

KW - Cold Temperature

KW - Energy Metabolism

KW - Fatty Acids

KW - Glucose

KW - Humans

KW - Insulin Resistance

KW - Male

KW - Thermogenesis

KW - Clinical Trial

KW - Journal Article

U2 - 10.1210/jc.2017-01250

DO - 10.1210/jc.2017-01250

M3 - SCORING: Journal article

C2 - 28945846

VL - 102

SP - 4226

EP - 4234

JO - J CLIN ENDOCR METAB

JF - J CLIN ENDOCR METAB

SN - 0021-972X

IS - 11

ER -