Cohesin is required for expression of the estrogen receptor-alpha (ESR1) gene.
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Cohesin is required for expression of the estrogen receptor-alpha (ESR1) gene. / Prenzel, Tanja; Kramer, Frank; Bedi, Upasana; Nagarajan, Sankari; Beissbarth, Tim; Johnsen, Steven A.
in: EPIGENET CHROMATIN, Jahrgang 5, Nr. 1, 1, 2012, S. 13.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Cohesin is required for expression of the estrogen receptor-alpha (ESR1) gene.
AU - Prenzel, Tanja
AU - Kramer, Frank
AU - Bedi, Upasana
AU - Nagarajan, Sankari
AU - Beissbarth, Tim
AU - Johnsen, Steven A.
PY - 2012
Y1 - 2012
N2 - In conjunction with posttranslational chromatin modifications, proper arrangement of higher order chromatin structure appears to be important for controlling transcription in the nucleus. Recent genome-wide studies have shown that the Estrogen Receptor-alpha (ER?), encoded by the ESR1 gene, nucleates tissue-specific long-range chromosomal interactions in collaboration with the cohesin complex. Furthermore, the Mediator complex not only regulates ER? activity, but also interacts with the cohesin complex to facilitate long-range chromosomal interactions. However, whether the cohesin and Mediator complexes function together to contribute to estrogen-regulated gene transcription remains unknown.
AB - In conjunction with posttranslational chromatin modifications, proper arrangement of higher order chromatin structure appears to be important for controlling transcription in the nucleus. Recent genome-wide studies have shown that the Estrogen Receptor-alpha (ER?), encoded by the ESR1 gene, nucleates tissue-specific long-range chromosomal interactions in collaboration with the cohesin complex. Furthermore, the Mediator complex not only regulates ER? activity, but also interacts with the cohesin complex to facilitate long-range chromosomal interactions. However, whether the cohesin and Mediator complexes function together to contribute to estrogen-regulated gene transcription remains unknown.
M3 - SCORING: Journal article
VL - 5
SP - 13
JO - EPIGENET CHROMATIN
JF - EPIGENET CHROMATIN
SN - 1756-8935
IS - 1
M1 - 1
ER -