Cloning, functional expression and mRNA distribution of an inwardly rectifying potassium channel protein
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Cloning, functional expression and mRNA distribution of an inwardly rectifying potassium channel protein. / Falk, T; Meyerhof, W; Corrette, B J; Schäfer, J; Bauer, Christiane K.; Schwarz, J R; Richter, D.
in: FEBS LETT, Jahrgang 367, Nr. 2, 2, 1995, S. 127-131.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Cloning, functional expression and mRNA distribution of an inwardly rectifying potassium channel protein
AU - Falk, T
AU - Meyerhof, W
AU - Corrette, B J
AU - Schäfer, J
AU - Bauer, Christiane K.
AU - Schwarz, J R
AU - Richter, D
PY - 1995
Y1 - 1995
N2 - In GH3/B6 cells at least two different inward K+ currents are observed that are regulated by thyrotropin-releasing hormone and somatostatin, respectively. Using a polymerase chain reaction based approach a cDNA was isolated and functionally expressed in human embryonic kidney cells that encodes an inward rectifier K+ channel, rIRK3, with a predicted molecular mass of 49.7 kDa. Corresponding transcripts of 2.6 kb have been detected in rat brain, pituitary and GH3/B6 cells. In situ hybridization revealed that rIRK3 mRNA is distributed throughout the brain and occurs predominantly in the piriform cortex, indusium griseum, supraoptic nucleus, facial nucleus and cerebellar Purkinje cells.
AB - In GH3/B6 cells at least two different inward K+ currents are observed that are regulated by thyrotropin-releasing hormone and somatostatin, respectively. Using a polymerase chain reaction based approach a cDNA was isolated and functionally expressed in human embryonic kidney cells that encodes an inward rectifier K+ channel, rIRK3, with a predicted molecular mass of 49.7 kDa. Corresponding transcripts of 2.6 kb have been detected in rat brain, pituitary and GH3/B6 cells. In situ hybridization revealed that rIRK3 mRNA is distributed throughout the brain and occurs predominantly in the piriform cortex, indusium griseum, supraoptic nucleus, facial nucleus and cerebellar Purkinje cells.
U2 - 10.1016/0014-5793(95)00527-g
DO - 10.1016/0014-5793(95)00527-g
M3 - SCORING: Zeitschriftenaufsatz
VL - 367
SP - 127
EP - 131
JO - FEBS LETT
JF - FEBS LETT
SN - 0014-5793
IS - 2
M1 - 2
ER -