Clinical impact of human Jurkat T-cell-line-derived antithymocyte globulin in multiple myeloma patients undergoing allogeneic stem cell transplantation.
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Clinical impact of human Jurkat T-cell-line-derived antithymocyte globulin in multiple myeloma patients undergoing allogeneic stem cell transplantation. / Ayuketang Ayuk, Francis; Perez-Simon, José A; Shimoni, Avichai; Sureda, Anna; Zabelina, Tatjana; Schwerdtfeger, Rainer; Martino, Rodrigo; Sayer, Herbert Gottfried; Alegre, Adrián; Lahuerta, Juan-José; Atanackovic, Djordje; Wolschke, Christine; Nagler, Arnon; Zander, Axel R.; Miguel, San; Kröger, Nicolaus; Kröger, Nicolaus.
in: HAEMATOLOGICA, Jahrgang 93, Nr. 9, 9, 2008, S. 1343-1350.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Clinical impact of human Jurkat T-cell-line-derived antithymocyte globulin in multiple myeloma patients undergoing allogeneic stem cell transplantation.
AU - Ayuketang Ayuk, Francis
AU - Perez-Simon, José A
AU - Shimoni, Avichai
AU - Sureda, Anna
AU - Zabelina, Tatjana
AU - Schwerdtfeger, Rainer
AU - Martino, Rodrigo
AU - Sayer, Herbert Gottfried
AU - Alegre, Adrián
AU - Lahuerta, Juan-José
AU - Atanackovic, Djordje
AU - Wolschke, Christine
AU - Nagler, Arnon
AU - Zander, Axel R.
AU - Miguel, San
AU - Kröger, Nicolaus
AU - Kröger, Nicolaus
PY - 2008
Y1 - 2008
N2 - BACKGROUND: Antithymocyte globulin or human Jurkat T-cell-line-derived antilymphocyte globulin is used in allogeneic stem cell transplantation to induce in vivo T-cell depletion to facilitate engraftment and lower graft-versus-host disease. In vitro studies suggest that antithymocyte globulin, besides causing T-cell depletion, has strong anti-myeloma activity. DESIGN AND METHODS: We evaluated the anti-myeloma activity of antilymphocyte globulin in a melphalan/fludarabine-based reduced intensity conditioning regimen as well as the incidence of graft-versus-host disease in 138 multiple myeloma patients who underwent allogeneic stem cell transplantation with (n=79) or without (n=59) antilymphocyte globulin. RESULTS: Leukocyte and platelet engraftment were faster in the group not receiving antilymphocyte globulin (13 vs. 16 days, p
AB - BACKGROUND: Antithymocyte globulin or human Jurkat T-cell-line-derived antilymphocyte globulin is used in allogeneic stem cell transplantation to induce in vivo T-cell depletion to facilitate engraftment and lower graft-versus-host disease. In vitro studies suggest that antithymocyte globulin, besides causing T-cell depletion, has strong anti-myeloma activity. DESIGN AND METHODS: We evaluated the anti-myeloma activity of antilymphocyte globulin in a melphalan/fludarabine-based reduced intensity conditioning regimen as well as the incidence of graft-versus-host disease in 138 multiple myeloma patients who underwent allogeneic stem cell transplantation with (n=79) or without (n=59) antilymphocyte globulin. RESULTS: Leukocyte and platelet engraftment were faster in the group not receiving antilymphocyte globulin (13 vs. 16 days, p
U2 - 10.3324/haematol.12665
DO - 10.3324/haematol.12665
M3 - SCORING: Zeitschriftenaufsatz
VL - 93
SP - 1343
EP - 1350
JO - HAEMATOLOGICA
JF - HAEMATOLOGICA
SN - 0390-6078
IS - 9
M1 - 9
ER -