Clinical impact of antibody formation to botulinum toxin A in children.
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Clinical impact of antibody formation to botulinum toxin A in children. / Herrmann, Jochen; Geth, Katrin; Mall, Volker; Bigalke, Hans; Jürgen, Schulte Mönting; Linder, Michaela; Kirschner, Jan; Berweck, Steffen; Korinthenberg, Rudolf; Heinen, Florian; Fietzek, Urban M.
in: ANN NEUROL, Jahrgang 55, Nr. 5, 5, 2004, S. 732-735.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Clinical impact of antibody formation to botulinum toxin A in children.
AU - Herrmann, Jochen
AU - Geth, Katrin
AU - Mall, Volker
AU - Bigalke, Hans
AU - Jürgen, Schulte Mönting
AU - Linder, Michaela
AU - Kirschner, Jan
AU - Berweck, Steffen
AU - Korinthenberg, Rudolf
AU - Heinen, Florian
AU - Fietzek, Urban M
PY - 2004
Y1 - 2004
N2 - We studied the clinical impact of neutralizing antibodies to botulinum toxin A that occurred during long-term treatment of children between 1993 and 2001. Antibodies were found in high titers in 35 of 110 (31.8%) samples from individual patients. Antibody formation correlated with secondary nonresponse (p <0.001). The most significant risk factors for antibody formation were the frequency of treatments (p = 0.0001) and the injection of a higher weight-adapted maximum dose per treatment (p = 0.001).
AB - We studied the clinical impact of neutralizing antibodies to botulinum toxin A that occurred during long-term treatment of children between 1993 and 2001. Antibodies were found in high titers in 35 of 110 (31.8%) samples from individual patients. Antibody formation correlated with secondary nonresponse (p <0.001). The most significant risk factors for antibody formation were the frequency of treatments (p = 0.0001) and the injection of a higher weight-adapted maximum dose per treatment (p = 0.001).
M3 - SCORING: Zeitschriftenaufsatz
VL - 55
SP - 732
EP - 735
JO - ANN NEUROL
JF - ANN NEUROL
SN - 0364-5134
IS - 5
M1 - 5
ER -