Clinical evaluation of an autofluorescence diagnostic device for oral cancer detection: a prospective randomized diagnostic study
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Clinical evaluation of an autofluorescence diagnostic device for oral cancer detection: a prospective randomized diagnostic study. / Rana, Majeed; Zapf, Antonia; Kuehle, Marco; Gellrich, Nils-Claudius; Eckardt, André M.
in: EUR J CANCER PREV, Jahrgang 21, Nr. 5, 09.2012, S. 460-466.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Clinical evaluation of an autofluorescence diagnostic device for oral cancer detection: a prospective randomized diagnostic study
AU - Rana, Majeed
AU - Zapf, Antonia
AU - Kuehle, Marco
AU - Gellrich, Nils-Claudius
AU - Eckardt, André M
PY - 2012/9
Y1 - 2012/9
N2 - The prognosis for patients with oral squamous cell carcinoma remains poor despite advances in multimodal treatment concepts. Early diagnosis and treatment is the key to improved patient survival. A device (VELscope) that uses autofluorescence technology, allowing direct fluorescence visualization of the oral cavity, might be a useful tool for oral cancer detection or as an adjunct to standard clinical examination. A total of 289 patients with oral premalignant lesions were randomly divided into two groups for clinical examination of precancerous oral lesions. In group 1, 166 patients were examined conventionally with white light, and in group 2, 123 patients were examined with the autofluorescence visualization device (VELscope) in addition to the white light examination. Biopsies were obtained from all suspicious areas identified in both examination groups (n=52). In the first step, baseline characteristics of the two groups (only white light vs. white light and VELscope) were compared to exclude selection bias. In the second step, for the group examined with white light and VELscope (123 patients), the diagnostic strategies were compared with regard to sensitivity and specificity using biopsy as the gold standard. The results showed that using the VELscope leads to higher sensitivity (100% instead of 17%), but to lower specificity (74% instead of 97%). Thus, we can conclude that the VELscope is a useful new diagnostic device for detection of oral cancer diseases.
AB - The prognosis for patients with oral squamous cell carcinoma remains poor despite advances in multimodal treatment concepts. Early diagnosis and treatment is the key to improved patient survival. A device (VELscope) that uses autofluorescence technology, allowing direct fluorescence visualization of the oral cavity, might be a useful tool for oral cancer detection or as an adjunct to standard clinical examination. A total of 289 patients with oral premalignant lesions were randomly divided into two groups for clinical examination of precancerous oral lesions. In group 1, 166 patients were examined conventionally with white light, and in group 2, 123 patients were examined with the autofluorescence visualization device (VELscope) in addition to the white light examination. Biopsies were obtained from all suspicious areas identified in both examination groups (n=52). In the first step, baseline characteristics of the two groups (only white light vs. white light and VELscope) were compared to exclude selection bias. In the second step, for the group examined with white light and VELscope (123 patients), the diagnostic strategies were compared with regard to sensitivity and specificity using biopsy as the gold standard. The results showed that using the VELscope leads to higher sensitivity (100% instead of 17%), but to lower specificity (74% instead of 97%). Thus, we can conclude that the VELscope is a useful new diagnostic device for detection of oral cancer diseases.
KW - Aged
KW - Biopsy
KW - Carcinoma, Squamous Cell
KW - Diagnosis, Oral
KW - Early Detection of Cancer
KW - Female
KW - Fluorescence
KW - Humans
KW - Light
KW - Male
KW - Middle Aged
KW - Mouth Neoplasms
KW - Precancerous Conditions
KW - Prospective Studies
KW - Sensitivity and Specificity
KW - Journal Article
KW - Randomized Controlled Trial
U2 - 10.1097/CEJ.0b013e32834fdb6d
DO - 10.1097/CEJ.0b013e32834fdb6d
M3 - SCORING: Journal article
C2 - 22217551
VL - 21
SP - 460
EP - 466
JO - EUR J CANCER PREV
JF - EUR J CANCER PREV
SN - 0959-8278
IS - 5
ER -