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Class II HLA interactions modulate genetic risk for multiple sclerosis

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Class II HLA interactions modulate genetic risk for multiple sclerosis. / Moutsianas, Loukas; Jostins, Luke; Beecham, Ashley H; Dilthey, Alexander T; Xifara, Dionysia K; Ban, Maria; Shah, Tejas S; Patsopoulos, Nikolaos A; Alfredsson, Lars; Anderson, Carl A; Attfield, Katherine E; Baranzini, Sergio E; Barrett, Jeffrey; Binder, Thomas M C; Booth, David; Buck, Dorothea; Celius, Elisabeth G; Cotsapas, Chris; D'Alfonso, Sandra; Dendrou, Calliope A; Donnelly, Peter; Dubois, Bénédicte; Fontaine, Bertrand; Lar Fugger, Lars; Goris, An; Gourraud, Pierre-Antoine; Graetz, Christiane; Hemmer, Bernhard; Hillert, Jan; Kockum, Ingrid; Leslie, Stephen; Lill, Christina M; Martinelli-Boneschi, Filippo; Oksenberg, Jorge R; Olsson, Tomas; Oturai, Annette; Saarela, Janna; Søndergaard, Helle Bach; Spurkland, Anne; Taylor, Bruce; Winkelmann, Juliane; Zipp, Frauke; Haines, Jonathan L; Pericak-Vance, Margaret A; Spencer, Chris C A; Stewart, Graeme; Hafler, David A; Ivinson, Adrian J; Harbo, Hanne F; Hauser, Stephen L; De Jager, Philip L; Compston, Alastair; McCauley, Jacob L; Sawcer, Stephen wcer; McVean, Gil; International IBD Genetics Consortium (IIBDGC).

in: NAT GENET, Jahrgang 47, Nr. 10, 10.2015, S. 1107-13.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Moutsianas, L, Jostins, L, Beecham, AH, Dilthey, AT, Xifara, DK, Ban, M, Shah, TS, Patsopoulos, NA, Alfredsson, L, Anderson, CA, Attfield, KE, Baranzini, SE, Barrett, J, Binder, TMC, Booth, D, Buck, D, Celius, EG, Cotsapas, C, D'Alfonso, S, Dendrou, CA, Donnelly, P, Dubois, B, Fontaine, B, Lar Fugger, L, Goris, A, Gourraud, P-A, Graetz, C, Hemmer, B, Hillert, J, Kockum, I, Leslie, S, Lill, CM, Martinelli-Boneschi, F, Oksenberg, JR, Olsson, T, Oturai, A, Saarela, J, Søndergaard, HB, Spurkland, A, Taylor, B, Winkelmann, J, Zipp, F, Haines, JL, Pericak-Vance, MA, Spencer, CCA, Stewart, G, Hafler, DA, Ivinson, AJ, Harbo, HF, Hauser, SL, De Jager, PL, Compston, A, McCauley, JL, Sawcer, SW, McVean, G & International IBD Genetics Consortium (IIBDGC) 2015, 'Class II HLA interactions modulate genetic risk for multiple sclerosis', NAT GENET, Jg. 47, Nr. 10, S. 1107-13. https://doi.org/10.1038/ng.3395

APA

Moutsianas, L., Jostins, L., Beecham, A. H., Dilthey, A. T., Xifara, D. K., Ban, M., Shah, T. S., Patsopoulos, N. A., Alfredsson, L., Anderson, C. A., Attfield, K. E., Baranzini, S. E., Barrett, J., Binder, T. M. C., Booth, D., Buck, D., Celius, E. G., Cotsapas, C., D'Alfonso, S., ... International IBD Genetics Consortium (IIBDGC) (2015). Class II HLA interactions modulate genetic risk for multiple sclerosis. NAT GENET, 47(10), 1107-13. https://doi.org/10.1038/ng.3395

Vancouver

Moutsianas L, Jostins L, Beecham AH, Dilthey AT, Xifara DK, Ban M et al. Class II HLA interactions modulate genetic risk for multiple sclerosis. NAT GENET. 2015 Okt;47(10):1107-13. https://doi.org/10.1038/ng.3395

Bibtex

@article{fef9bb9eeabe49d8a323e015ca931481,
title = "Class II HLA interactions modulate genetic risk for multiple sclerosis",
abstract = "Association studies have greatly refined the understanding of how variation within the human leukocyte antigen (HLA) genes influences risk of multiple sclerosis. However, the extent to which major effects are modulated by interactions is poorly characterized. We analyzed high-density SNP data on 17,465 cases and 30,385 controls from 11 cohorts of European ancestry, in combination with imputation of classical HLA alleles, to build a high-resolution map of HLA genetic risk and assess the evidence for interactions involving classical HLA alleles. Among new and previously identified class II risk alleles (HLA-DRB1*15:01, HLA-DRB1*13:03, HLA-DRB1*03:01, HLA-DRB1*08:01 and HLA-DQB1*03:02) and class I protective alleles (HLA-A*02:01, HLA-B*44:02, HLA-B*38:01 and HLA-B*55:01), we find evidence for two interactions involving pairs of class II alleles: HLA-DQA1*01:01-HLA-DRB1*15:01 and HLA-DQB1*03:01-HLA-DQB1*03:02. We find no evidence for interactions between classical HLA alleles and non-HLA risk-associated variants and estimate a minimal effect of polygenic epistasis in modulating major risk alleles.",
keywords = "Alleles, Epistasis, Genetic, Genetic Predisposition to Disease, Histocompatibility Antigens Class II, Humans, Multiple Sclerosis, Polymorphism, Single Nucleotide",
author = "Loukas Moutsianas and Luke Jostins and Beecham, {Ashley H} and Dilthey, {Alexander T} and Xifara, {Dionysia K} and Maria Ban and Shah, {Tejas S} and Patsopoulos, {Nikolaos A} and Lars Alfredsson and Anderson, {Carl A} and Attfield, {Katherine E} and Baranzini, {Sergio E} and Jeffrey Barrett and Binder, {Thomas M C} and David Booth and Dorothea Buck and Celius, {Elisabeth G} and Chris Cotsapas and Sandra D'Alfonso and Dendrou, {Calliope A} and Peter Donnelly and B{\'e}n{\'e}dicte Dubois and Bertrand Fontaine and {Lar Fugger}, Lars and An Goris and Pierre-Antoine Gourraud and Christiane Graetz and Bernhard Hemmer and Jan Hillert and Ingrid Kockum and Stephen Leslie and Lill, {Christina M} and Filippo Martinelli-Boneschi and Oksenberg, {Jorge R} and Tomas Olsson and Annette Oturai and Janna Saarela and S{\o}ndergaard, {Helle Bach} and Anne Spurkland and Bruce Taylor and Juliane Winkelmann and Frauke Zipp and Haines, {Jonathan L} and Pericak-Vance, {Margaret A} and Spencer, {Chris C A} and Graeme Stewart and Hafler, {David A} and Ivinson, {Adrian J} and Harbo, {Hanne F} and Hauser, {Stephen L} and {De Jager}, {Philip L} and Alastair Compston and McCauley, {Jacob L} and Sawcer, {Stephen wcer} and Gil McVean and {International IBD Genetics Consortium (IIBDGC)}",
year = "2015",
month = oct,
doi = "10.1038/ng.3395",
language = "English",
volume = "47",
pages = "1107--13",
journal = "NAT GENET",
issn = "1061-4036",
publisher = "NATURE PUBLISHING GROUP",
number = "10",

}

RIS

TY - JOUR

T1 - Class II HLA interactions modulate genetic risk for multiple sclerosis

AU - Moutsianas, Loukas

AU - Jostins, Luke

AU - Beecham, Ashley H

AU - Dilthey, Alexander T

AU - Xifara, Dionysia K

AU - Ban, Maria

AU - Shah, Tejas S

AU - Patsopoulos, Nikolaos A

AU - Alfredsson, Lars

AU - Anderson, Carl A

AU - Attfield, Katherine E

AU - Baranzini, Sergio E

AU - Barrett, Jeffrey

AU - Binder, Thomas M C

AU - Booth, David

AU - Buck, Dorothea

AU - Celius, Elisabeth G

AU - Cotsapas, Chris

AU - D'Alfonso, Sandra

AU - Dendrou, Calliope A

AU - Donnelly, Peter

AU - Dubois, Bénédicte

AU - Fontaine, Bertrand

AU - Lar Fugger, Lars

AU - Goris, An

AU - Gourraud, Pierre-Antoine

AU - Graetz, Christiane

AU - Hemmer, Bernhard

AU - Hillert, Jan

AU - Kockum, Ingrid

AU - Leslie, Stephen

AU - Lill, Christina M

AU - Martinelli-Boneschi, Filippo

AU - Oksenberg, Jorge R

AU - Olsson, Tomas

AU - Oturai, Annette

AU - Saarela, Janna

AU - Søndergaard, Helle Bach

AU - Spurkland, Anne

AU - Taylor, Bruce

AU - Winkelmann, Juliane

AU - Zipp, Frauke

AU - Haines, Jonathan L

AU - Pericak-Vance, Margaret A

AU - Spencer, Chris C A

AU - Stewart, Graeme

AU - Hafler, David A

AU - Ivinson, Adrian J

AU - Harbo, Hanne F

AU - Hauser, Stephen L

AU - De Jager, Philip L

AU - Compston, Alastair

AU - McCauley, Jacob L

AU - Sawcer, Stephen wcer

AU - McVean, Gil

AU - International IBD Genetics Consortium (IIBDGC)

PY - 2015/10

Y1 - 2015/10

N2 - Association studies have greatly refined the understanding of how variation within the human leukocyte antigen (HLA) genes influences risk of multiple sclerosis. However, the extent to which major effects are modulated by interactions is poorly characterized. We analyzed high-density SNP data on 17,465 cases and 30,385 controls from 11 cohorts of European ancestry, in combination with imputation of classical HLA alleles, to build a high-resolution map of HLA genetic risk and assess the evidence for interactions involving classical HLA alleles. Among new and previously identified class II risk alleles (HLA-DRB1*15:01, HLA-DRB1*13:03, HLA-DRB1*03:01, HLA-DRB1*08:01 and HLA-DQB1*03:02) and class I protective alleles (HLA-A*02:01, HLA-B*44:02, HLA-B*38:01 and HLA-B*55:01), we find evidence for two interactions involving pairs of class II alleles: HLA-DQA1*01:01-HLA-DRB1*15:01 and HLA-DQB1*03:01-HLA-DQB1*03:02. We find no evidence for interactions between classical HLA alleles and non-HLA risk-associated variants and estimate a minimal effect of polygenic epistasis in modulating major risk alleles.

AB - Association studies have greatly refined the understanding of how variation within the human leukocyte antigen (HLA) genes influences risk of multiple sclerosis. However, the extent to which major effects are modulated by interactions is poorly characterized. We analyzed high-density SNP data on 17,465 cases and 30,385 controls from 11 cohorts of European ancestry, in combination with imputation of classical HLA alleles, to build a high-resolution map of HLA genetic risk and assess the evidence for interactions involving classical HLA alleles. Among new and previously identified class II risk alleles (HLA-DRB1*15:01, HLA-DRB1*13:03, HLA-DRB1*03:01, HLA-DRB1*08:01 and HLA-DQB1*03:02) and class I protective alleles (HLA-A*02:01, HLA-B*44:02, HLA-B*38:01 and HLA-B*55:01), we find evidence for two interactions involving pairs of class II alleles: HLA-DQA1*01:01-HLA-DRB1*15:01 and HLA-DQB1*03:01-HLA-DQB1*03:02. We find no evidence for interactions between classical HLA alleles and non-HLA risk-associated variants and estimate a minimal effect of polygenic epistasis in modulating major risk alleles.

KW - Alleles

KW - Epistasis, Genetic

KW - Genetic Predisposition to Disease

KW - Histocompatibility Antigens Class II

KW - Humans

KW - Multiple Sclerosis

KW - Polymorphism, Single Nucleotide

U2 - 10.1038/ng.3395

DO - 10.1038/ng.3395

M3 - SCORING: Journal article

C2 - 26343388

VL - 47

SP - 1107

EP - 1113

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 10

ER -