Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement
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Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement. / Horwitz, E M; Le Blanc, K; Dominici, M; Mueller, I; Slaper-Cortenbach, I; Marini, F C; Deans, R J; Krause, D S; Keating, A.
in: CYTOTHERAPY, Jahrgang 7, Nr. 5, 2005, S. 393-395.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement
AU - Horwitz, E M
AU - Le Blanc, K
AU - Dominici, M
AU - Mueller, I
AU - Slaper-Cortenbach, I
AU - Marini, F C
AU - Deans, R J
AU - Krause, D S
AU - Keating, A
PY - 2005
Y1 - 2005
N2 - The plastic-adherent cells isolated from BM and other sources have come to be widely known as mesenchymal stem cells (MSC). However, the recognized biologic properties of the unfractionated population of cells do not seem to meet generally accepted criteria for stem cell activity, rendering the name scientifically inaccurate and potentially misleading to the lay public. Nonetheless, a bona fide MSC most certainly exists. To address this inconsistency between nomenclature and biologic properties, and to clarify the terminology, we suggest that the fibroblast-like plastic-adherent cells, regardless of the tissue from which they are isolated, be termed multipotent mesenchymal stromal cells, while the term mesenchymal stem cells is used only for cells that meet specified stem cell criteria. The widely recognized acronym, MSC, may be used for both cell populations, as is the current practice; thus, investigators must clearly define the more scientifically correct designation in their reports. The International Society for Cellular Therapy (ISCT) encourages the scientific community to adopt this uniform nomenclature in all written and oral communications.
AB - The plastic-adherent cells isolated from BM and other sources have come to be widely known as mesenchymal stem cells (MSC). However, the recognized biologic properties of the unfractionated population of cells do not seem to meet generally accepted criteria for stem cell activity, rendering the name scientifically inaccurate and potentially misleading to the lay public. Nonetheless, a bona fide MSC most certainly exists. To address this inconsistency between nomenclature and biologic properties, and to clarify the terminology, we suggest that the fibroblast-like plastic-adherent cells, regardless of the tissue from which they are isolated, be termed multipotent mesenchymal stromal cells, while the term mesenchymal stem cells is used only for cells that meet specified stem cell criteria. The widely recognized acronym, MSC, may be used for both cell populations, as is the current practice; thus, investigators must clearly define the more scientifically correct designation in their reports. The International Society for Cellular Therapy (ISCT) encourages the scientific community to adopt this uniform nomenclature in all written and oral communications.
KW - Mesenchymal Stromal Cells
KW - Multipotent Stem Cells
KW - Stromal Cells
KW - Terminology as Topic
U2 - 10.1080/14653240500319234
DO - 10.1080/14653240500319234
M3 - SCORING: Journal article
C2 - 16236628
VL - 7
SP - 393
EP - 395
JO - CYTOTHERAPY
JF - CYTOTHERAPY
SN - 1465-3249
IS - 5
ER -