Circulating Tumour Cells, Circulating Tumour DNA and Circulating MicroRNA in Metastatic Breast Carcinoma - What is the Role of Liquid Biopsy in Breast Cancer?
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Circulating Tumour Cells, Circulating Tumour DNA and Circulating MicroRNA in Metastatic Breast Carcinoma - What is the Role of Liquid Biopsy in Breast Cancer? / Polasik, Arkadius; Tzschaschel, Marie; Schochter, Fabienne; de Gregorio, Amelie; Friedl, Thomas W P; Rack, Brigitte; Hartkopf, Andreas; Fasching, Peter A; Schneeweiss, Andreas; Müller, Volkmar; Huober, Jens; Janni, Wolfgang; Fehm, Tanja.
in: GEBURTSH FRAUENHEILK, Jahrgang 77, Nr. 12, 12.2017, S. 1291-1298.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Circulating Tumour Cells, Circulating Tumour DNA and Circulating MicroRNA in Metastatic Breast Carcinoma - What is the Role of Liquid Biopsy in Breast Cancer?
AU - Polasik, Arkadius
AU - Tzschaschel, Marie
AU - Schochter, Fabienne
AU - de Gregorio, Amelie
AU - Friedl, Thomas W P
AU - Rack, Brigitte
AU - Hartkopf, Andreas
AU - Fasching, Peter A
AU - Schneeweiss, Andreas
AU - Müller, Volkmar
AU - Huober, Jens
AU - Janni, Wolfgang
AU - Fehm, Tanja
PY - 2017/12
Y1 - 2017/12
N2 - Dissemination of tumour cells and the development of solid metastases occurs via blood vessels and lymphatics. Circulating tumour cells (CTCs) and circulating tumour DNA (ctDNA) can be detected in venous blood in patients with early and metastatic breast cancer, and their prognostic relevance has been demonstrated on numerous occasions. Repeated testing for CTCs and ctDNA, or regular so-called "liquid biopsy", can be performed easily at any stage during the course of disease. Additional molecular analysis allows definition of tumour characteristics and heterogeneity that may be associated with treatment resistance. This in turn makes personalised, targeted treatments possible that may achieve both improved overall survival and quality of life.
AB - Dissemination of tumour cells and the development of solid metastases occurs via blood vessels and lymphatics. Circulating tumour cells (CTCs) and circulating tumour DNA (ctDNA) can be detected in venous blood in patients with early and metastatic breast cancer, and their prognostic relevance has been demonstrated on numerous occasions. Repeated testing for CTCs and ctDNA, or regular so-called "liquid biopsy", can be performed easily at any stage during the course of disease. Additional molecular analysis allows definition of tumour characteristics and heterogeneity that may be associated with treatment resistance. This in turn makes personalised, targeted treatments possible that may achieve both improved overall survival and quality of life.
KW - Journal Article
U2 - 10.1055/s-0043-122884
DO - 10.1055/s-0043-122884
M3 - SCORING: Review article
C2 - 29269956
VL - 77
SP - 1291
EP - 1298
JO - GEBURTSH FRAUENHEILK
JF - GEBURTSH FRAUENHEILK
SN - 0016-5751
IS - 12
ER -