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Circulating growth factor levels are associated with tumorigenesis in neurofibromatosis type 1

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Circulating growth factor levels are associated with tumorigenesis in neurofibromatosis type 1. / Mashour, George A; Driever, Pablo Hernáiz; Hartmann, Melanie; Drissel, Stephanie N; Zhang, Tingguo; Scharf, Bianca; Felderhoff-Müser, Ursula; Sakuma, Sadatoshi; Friedrich, Reinhard E; Martuza, Robert L; Mautner, Victor Felix; Kurtz, Andreas.

in: CLIN CANCER RES, Jahrgang 10, Nr. 17, 01.09.2004, S. 5677-83.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mashour, GA, Driever, PH, Hartmann, M, Drissel, SN, Zhang, T, Scharf, B, Felderhoff-Müser, U, Sakuma, S, Friedrich, RE, Martuza, RL, Mautner, VF & Kurtz, A 2004, 'Circulating growth factor levels are associated with tumorigenesis in neurofibromatosis type 1', CLIN CANCER RES, Jg. 10, Nr. 17, S. 5677-83. https://doi.org/10.1158/1078-0432.CCR-03-0769

APA

Mashour, G. A., Driever, P. H., Hartmann, M., Drissel, S. N., Zhang, T., Scharf, B., Felderhoff-Müser, U., Sakuma, S., Friedrich, R. E., Martuza, R. L., Mautner, V. F., & Kurtz, A. (2004). Circulating growth factor levels are associated with tumorigenesis in neurofibromatosis type 1. CLIN CANCER RES, 10(17), 5677-83. https://doi.org/10.1158/1078-0432.CCR-03-0769

Vancouver

Mashour GA, Driever PH, Hartmann M, Drissel SN, Zhang T, Scharf B et al. Circulating growth factor levels are associated with tumorigenesis in neurofibromatosis type 1. CLIN CANCER RES. 2004 Sep 1;10(17):5677-83. https://doi.org/10.1158/1078-0432.CCR-03-0769

Bibtex

@article{2cf26db3f2fc45f785fd46a47efae5b7,
title = "Circulating growth factor levels are associated with tumorigenesis in neurofibromatosis type 1",
abstract = "PURPOSE: Neurofibromatosis type 1 (NF1) is characterized by systemic development of neurofibromas. Early clinical diagnosis can be ambiguous, and genetic diagnosis can be prohibitively difficult. Dysregulation of a number of growth factors has been suggested to be a mechanism of pathogenesis. This study was performed to assess the contribution of circulating growth factors for diffuse tumorigenesis and the diagnostic value of circulating growth factor identification in serum.EXPERIMENTAL DESIGN: The growth stimulation of neurofibroma-derived cells by serum from NF1 patients was tested, and serum growth factor levels in a cohort of NF1 patients (n = 39) between the ages of 7 and 70 years were analyzed.RESULTS: Concentrations of midkine (MK) and stem cell factor, but not epidermal growth factor, were substantially increased in serum of NF1 patients when compared with healthy controls. Within the NF1 group, MK levels increased dramatically at puberty from an average of 0.79 ng/mL in patients <18 years to 1.18 ng/mL in patients >18 years old. Stem cell factor and MK concentrations above a defined threshold in serum of NF1 patients are of diagnostic benefit for 96% of patients in the cohort tested. Furthermore, serum from NF1 patients enhanced proliferation of human neurofibroma-derived primary Schwann cells and endothelial cells substantially better than normal serum.CONCLUSIONS: Enhanced circulating growth factor levels contribute to diffuse tumorigenesis in NF1 and may provide the basis for molecular diagnosis.",
keywords = "Adolescent, Adult, Aged, Case-Control Studies, Cell Proliferation, Cell Transformation, Neoplastic, Child, Child, Preschool, Cohort Studies, Cytokines, Endothelial Cells, Epidermal Growth Factor, Female, Gene Expression Regulation, Developmental, Gene Expression Regulation, Neoplastic, Humans, Male, Middle Aged, Neurofibromatosis 1, Schwann Cells, Stem Cell Factor",
author = "Mashour, {George A} and Driever, {Pablo Hern{\'a}iz} and Melanie Hartmann and Drissel, {Stephanie N} and Tingguo Zhang and Bianca Scharf and Ursula Felderhoff-M{\"u}ser and Sadatoshi Sakuma and Friedrich, {Reinhard E} and Martuza, {Robert L} and Mautner, {Victor Felix} and Andreas Kurtz",
year = "2004",
month = sep,
day = "1",
doi = "10.1158/1078-0432.CCR-03-0769",
language = "English",
volume = "10",
pages = "5677--83",
journal = "CLIN CANCER RES",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "17",

}

RIS

TY - JOUR

T1 - Circulating growth factor levels are associated with tumorigenesis in neurofibromatosis type 1

AU - Mashour, George A

AU - Driever, Pablo Hernáiz

AU - Hartmann, Melanie

AU - Drissel, Stephanie N

AU - Zhang, Tingguo

AU - Scharf, Bianca

AU - Felderhoff-Müser, Ursula

AU - Sakuma, Sadatoshi

AU - Friedrich, Reinhard E

AU - Martuza, Robert L

AU - Mautner, Victor Felix

AU - Kurtz, Andreas

PY - 2004/9/1

Y1 - 2004/9/1

N2 - PURPOSE: Neurofibromatosis type 1 (NF1) is characterized by systemic development of neurofibromas. Early clinical diagnosis can be ambiguous, and genetic diagnosis can be prohibitively difficult. Dysregulation of a number of growth factors has been suggested to be a mechanism of pathogenesis. This study was performed to assess the contribution of circulating growth factors for diffuse tumorigenesis and the diagnostic value of circulating growth factor identification in serum.EXPERIMENTAL DESIGN: The growth stimulation of neurofibroma-derived cells by serum from NF1 patients was tested, and serum growth factor levels in a cohort of NF1 patients (n = 39) between the ages of 7 and 70 years were analyzed.RESULTS: Concentrations of midkine (MK) and stem cell factor, but not epidermal growth factor, were substantially increased in serum of NF1 patients when compared with healthy controls. Within the NF1 group, MK levels increased dramatically at puberty from an average of 0.79 ng/mL in patients <18 years to 1.18 ng/mL in patients >18 years old. Stem cell factor and MK concentrations above a defined threshold in serum of NF1 patients are of diagnostic benefit for 96% of patients in the cohort tested. Furthermore, serum from NF1 patients enhanced proliferation of human neurofibroma-derived primary Schwann cells and endothelial cells substantially better than normal serum.CONCLUSIONS: Enhanced circulating growth factor levels contribute to diffuse tumorigenesis in NF1 and may provide the basis for molecular diagnosis.

AB - PURPOSE: Neurofibromatosis type 1 (NF1) is characterized by systemic development of neurofibromas. Early clinical diagnosis can be ambiguous, and genetic diagnosis can be prohibitively difficult. Dysregulation of a number of growth factors has been suggested to be a mechanism of pathogenesis. This study was performed to assess the contribution of circulating growth factors for diffuse tumorigenesis and the diagnostic value of circulating growth factor identification in serum.EXPERIMENTAL DESIGN: The growth stimulation of neurofibroma-derived cells by serum from NF1 patients was tested, and serum growth factor levels in a cohort of NF1 patients (n = 39) between the ages of 7 and 70 years were analyzed.RESULTS: Concentrations of midkine (MK) and stem cell factor, but not epidermal growth factor, were substantially increased in serum of NF1 patients when compared with healthy controls. Within the NF1 group, MK levels increased dramatically at puberty from an average of 0.79 ng/mL in patients <18 years to 1.18 ng/mL in patients >18 years old. Stem cell factor and MK concentrations above a defined threshold in serum of NF1 patients are of diagnostic benefit for 96% of patients in the cohort tested. Furthermore, serum from NF1 patients enhanced proliferation of human neurofibroma-derived primary Schwann cells and endothelial cells substantially better than normal serum.CONCLUSIONS: Enhanced circulating growth factor levels contribute to diffuse tumorigenesis in NF1 and may provide the basis for molecular diagnosis.

KW - Adolescent

KW - Adult

KW - Aged

KW - Case-Control Studies

KW - Cell Proliferation

KW - Cell Transformation, Neoplastic

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Cytokines

KW - Endothelial Cells

KW - Epidermal Growth Factor

KW - Female

KW - Gene Expression Regulation, Developmental

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Male

KW - Middle Aged

KW - Neurofibromatosis 1

KW - Schwann Cells

KW - Stem Cell Factor

U2 - 10.1158/1078-0432.CCR-03-0769

DO - 10.1158/1078-0432.CCR-03-0769

M3 - SCORING: Journal article

C2 - 15355893

VL - 10

SP - 5677

EP - 5683

JO - CLIN CANCER RES

JF - CLIN CANCER RES

SN - 1078-0432

IS - 17

ER -