Circulating concentrations of cardiac proteins in complicated and uncomplicated Plasmodium falciparum malaria.
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Circulating concentrations of cardiac proteins in complicated and uncomplicated Plasmodium falciparum malaria. / Ehrhardt, S; Wichmann, Dominic; Hemmer, C J; Burchard, G D; Brattig, N W.
in: TROP MED INT HEALTH, Jahrgang 9, Nr. 10, 10, 2004, S. 1099-1103.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Circulating concentrations of cardiac proteins in complicated and uncomplicated Plasmodium falciparum malaria.
AU - Ehrhardt, S
AU - Wichmann, Dominic
AU - Hemmer, C J
AU - Burchard, G D
AU - Brattig, N W
PY - 2004
Y1 - 2004
N2 - In an unmatched case-control study of 63 non-immune European patients with uncomplicated (n = 52) and complicated (n = 11) falciparum malaria, serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), heart-type fatty acid-binding protein (H-FABP), myoglobin, troponin T and creatin kinase-muscle brain were compared. Elevated levels of NT-proBNP and H-FABP indicated myocardial impairment in complicated but not in uncomplicated falciparum malaria. The clinical impact of these findings remains to be evaluated. The pathophysiology of cardiac impairment in complicated falciparum malaria warrants further investigation.
AB - In an unmatched case-control study of 63 non-immune European patients with uncomplicated (n = 52) and complicated (n = 11) falciparum malaria, serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), heart-type fatty acid-binding protein (H-FABP), myoglobin, troponin T and creatin kinase-muscle brain were compared. Elevated levels of NT-proBNP and H-FABP indicated myocardial impairment in complicated but not in uncomplicated falciparum malaria. The clinical impact of these findings remains to be evaluated. The pathophysiology of cardiac impairment in complicated falciparum malaria warrants further investigation.
M3 - SCORING: Zeitschriftenaufsatz
VL - 9
SP - 1099
EP - 1103
JO - TROP MED INT HEALTH
JF - TROP MED INT HEALTH
SN - 1360-2276
IS - 10
M1 - 10
ER -