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Circulating 25-hydroxyvitamin D and postmenopausal breast cancer survival: Influence of tumor characteristics and lifestyle factors?

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Circulating 25-hydroxyvitamin D and postmenopausal breast cancer survival: Influence of tumor characteristics and lifestyle factors? / Vrieling, Alina; Seibold, Petra; Johnson, Theron S; Heinz, Judith; Obi-Osius, Nadia; Kaaks, Rudolf; Flesch-Janys, Dieter; Chang-Claude, Jenny.

in: INT J CANCER, Jahrgang 134, Nr. 12, 15.06.2014, S. 2972-83.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Vrieling, A, Seibold, P, Johnson, TS, Heinz, J, Obi-Osius, N, Kaaks, R, Flesch-Janys, D & Chang-Claude, J 2014, 'Circulating 25-hydroxyvitamin D and postmenopausal breast cancer survival: Influence of tumor characteristics and lifestyle factors?', INT J CANCER, Jg. 134, Nr. 12, S. 2972-83. https://doi.org/10.1002/ijc.28628

APA

Vrieling, A., Seibold, P., Johnson, T. S., Heinz, J., Obi-Osius, N., Kaaks, R., Flesch-Janys, D., & Chang-Claude, J. (2014). Circulating 25-hydroxyvitamin D and postmenopausal breast cancer survival: Influence of tumor characteristics and lifestyle factors? INT J CANCER, 134(12), 2972-83. https://doi.org/10.1002/ijc.28628

Vancouver

Vrieling A, Seibold P, Johnson TS, Heinz J, Obi-Osius N, Kaaks R et al. Circulating 25-hydroxyvitamin D and postmenopausal breast cancer survival: Influence of tumor characteristics and lifestyle factors? INT J CANCER. 2014 Jun 15;134(12):2972-83. https://doi.org/10.1002/ijc.28628

Bibtex

@article{f81d07afe1e04f79b39d84770921a591,
title = "Circulating 25-hydroxyvitamin D and postmenopausal breast cancer survival: Influence of tumor characteristics and lifestyle factors?",
abstract = "We previously reported that lower post-diagnostic circulating 25-hydroxyvitamin D [25(OH)D] concentrations were associated with higher risk of overall mortality and distant disease in stage I-IV postmenopausal breast cancer survivors. This association was now re-examined in an extended dataset to investigate potential effect modification by tumor characteristics and lifestyle factors. A prospective cohort study was conducted in Germany including 2,177 incident stage I-IV postmenopausal breast cancer patients aged 50-74 years. Patients were diagnosed between 2001 and 2005 and median follow-up time was 5.3 years. Cox proportional hazards models were stratified by age at diagnosis, study center and season of blood collection and adjusted for other prognostic factors. A meta-analysis of studies on circulating 25(OH)D and mortality in breast cancer patients was performed to summarize evidence. Lower concentrations of 25(OH)D were significantly associated with higher risk of overall mortality [hazard ratio (HR) lowest vs. highest tertile = 1.86; 95% confidence interval (CI): 1.22, 2.82; p-trend = 0.002] and distant disease (HR = 1.76; 95% CI: 1.24, 2.49; p-trend = 0.003) in stage I-IIIa but not in stage IIIb-IV breast cancer patients. No significant interaction by lifestyle factors was observed (all p-interaction > 0.05). The meta-analysis yielded significant associations with overall and breast cancer-specific mortality (lowest vs. highest quantile: HR = 1.52; 95% CI: 1.22, 1.88 and HR = 1.74; 95% CI: 1.23, 2.40, respectively). In conclusion, post-diagnostic circulating 25(OH)D concentrations were associated with overall mortality and distant disease in stage I-IIIa postmenopausal breast cancer patients. This association was not strongly modified by lifestyle factors.",
keywords = "Aged, Breast Neoplasms, Cohort Studies, Female, Germany, Humans, Life Style, Middle Aged, Neoplasm Staging, Postmenopause, Prospective Studies, Risk, Risk Factors, Survival, Vitamin D",
author = "Alina Vrieling and Petra Seibold and Johnson, {Theron S} and Judith Heinz and Nadia Obi-Osius and Rudolf Kaaks and Dieter Flesch-Janys and Jenny Chang-Claude",
note = "{\textcopyright} 2013 UICC.",
year = "2014",
month = jun,
day = "15",
doi = "10.1002/ijc.28628",
language = "English",
volume = "134",
pages = "2972--83",
journal = "INT J CANCER",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "12",

}

RIS

TY - JOUR

T1 - Circulating 25-hydroxyvitamin D and postmenopausal breast cancer survival: Influence of tumor characteristics and lifestyle factors?

AU - Vrieling, Alina

AU - Seibold, Petra

AU - Johnson, Theron S

AU - Heinz, Judith

AU - Obi-Osius, Nadia

AU - Kaaks, Rudolf

AU - Flesch-Janys, Dieter

AU - Chang-Claude, Jenny

N1 - © 2013 UICC.

PY - 2014/6/15

Y1 - 2014/6/15

N2 - We previously reported that lower post-diagnostic circulating 25-hydroxyvitamin D [25(OH)D] concentrations were associated with higher risk of overall mortality and distant disease in stage I-IV postmenopausal breast cancer survivors. This association was now re-examined in an extended dataset to investigate potential effect modification by tumor characteristics and lifestyle factors. A prospective cohort study was conducted in Germany including 2,177 incident stage I-IV postmenopausal breast cancer patients aged 50-74 years. Patients were diagnosed between 2001 and 2005 and median follow-up time was 5.3 years. Cox proportional hazards models were stratified by age at diagnosis, study center and season of blood collection and adjusted for other prognostic factors. A meta-analysis of studies on circulating 25(OH)D and mortality in breast cancer patients was performed to summarize evidence. Lower concentrations of 25(OH)D were significantly associated with higher risk of overall mortality [hazard ratio (HR) lowest vs. highest tertile = 1.86; 95% confidence interval (CI): 1.22, 2.82; p-trend = 0.002] and distant disease (HR = 1.76; 95% CI: 1.24, 2.49; p-trend = 0.003) in stage I-IIIa but not in stage IIIb-IV breast cancer patients. No significant interaction by lifestyle factors was observed (all p-interaction > 0.05). The meta-analysis yielded significant associations with overall and breast cancer-specific mortality (lowest vs. highest quantile: HR = 1.52; 95% CI: 1.22, 1.88 and HR = 1.74; 95% CI: 1.23, 2.40, respectively). In conclusion, post-diagnostic circulating 25(OH)D concentrations were associated with overall mortality and distant disease in stage I-IIIa postmenopausal breast cancer patients. This association was not strongly modified by lifestyle factors.

AB - We previously reported that lower post-diagnostic circulating 25-hydroxyvitamin D [25(OH)D] concentrations were associated with higher risk of overall mortality and distant disease in stage I-IV postmenopausal breast cancer survivors. This association was now re-examined in an extended dataset to investigate potential effect modification by tumor characteristics and lifestyle factors. A prospective cohort study was conducted in Germany including 2,177 incident stage I-IV postmenopausal breast cancer patients aged 50-74 years. Patients were diagnosed between 2001 and 2005 and median follow-up time was 5.3 years. Cox proportional hazards models were stratified by age at diagnosis, study center and season of blood collection and adjusted for other prognostic factors. A meta-analysis of studies on circulating 25(OH)D and mortality in breast cancer patients was performed to summarize evidence. Lower concentrations of 25(OH)D were significantly associated with higher risk of overall mortality [hazard ratio (HR) lowest vs. highest tertile = 1.86; 95% confidence interval (CI): 1.22, 2.82; p-trend = 0.002] and distant disease (HR = 1.76; 95% CI: 1.24, 2.49; p-trend = 0.003) in stage I-IIIa but not in stage IIIb-IV breast cancer patients. No significant interaction by lifestyle factors was observed (all p-interaction > 0.05). The meta-analysis yielded significant associations with overall and breast cancer-specific mortality (lowest vs. highest quantile: HR = 1.52; 95% CI: 1.22, 1.88 and HR = 1.74; 95% CI: 1.23, 2.40, respectively). In conclusion, post-diagnostic circulating 25(OH)D concentrations were associated with overall mortality and distant disease in stage I-IIIa postmenopausal breast cancer patients. This association was not strongly modified by lifestyle factors.

KW - Aged

KW - Breast Neoplasms

KW - Cohort Studies

KW - Female

KW - Germany

KW - Humans

KW - Life Style

KW - Middle Aged

KW - Neoplasm Staging

KW - Postmenopause

KW - Prospective Studies

KW - Risk

KW - Risk Factors

KW - Survival

KW - Vitamin D

U2 - 10.1002/ijc.28628

DO - 10.1002/ijc.28628

M3 - SCORING: Journal article

C2 - 24272459

VL - 134

SP - 2972

EP - 2983

JO - INT J CANCER

JF - INT J CANCER

SN - 0020-7136

IS - 12

ER -