Circadian rhythm in rat brain opiate receptor.
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Circadian rhythm in rat brain opiate receptor. / Naber, Dieter; Wirz-Justice, A; Kafka, M S.
in: NEUROSCI LETT, Jahrgang 21, Nr. 1, 1, 1981, S. 45-50.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Circadian rhythm in rat brain opiate receptor.
AU - Naber, Dieter
AU - Wirz-Justice, A
AU - Kafka, M S
PY - 1981
Y1 - 1981
N2 - To investigate diurnal variations in opiate receptor binding, the amount of specifically bound [3H]naloxone was measured at 4-h intervals across a 24-h period in the forebrains of rats that had been housed under a controlled light--dark cycle (lights on from 07.00 to 19.00 h) for 3 weeks. A significant rhythm with a peak at 22.00 h was found, the amplitude was 46--78%. In the absence of time cues, this circadian rhythm persisted with a peak at 02.00--06.00 h and an amplitude of 88%. Scatchard analysis indicated that the differences in binding throughout the day were due not to changes in affinity, but to changes in the number of binding sites.
AB - To investigate diurnal variations in opiate receptor binding, the amount of specifically bound [3H]naloxone was measured at 4-h intervals across a 24-h period in the forebrains of rats that had been housed under a controlled light--dark cycle (lights on from 07.00 to 19.00 h) for 3 weeks. A significant rhythm with a peak at 22.00 h was found, the amplitude was 46--78%. In the absence of time cues, this circadian rhythm persisted with a peak at 02.00--06.00 h and an amplitude of 88%. Scatchard analysis indicated that the differences in binding throughout the day were due not to changes in affinity, but to changes in the number of binding sites.
M3 - SCORING: Zeitschriftenaufsatz
VL - 21
SP - 45
EP - 50
JO - NEUROSCI LETT
JF - NEUROSCI LETT
SN - 0304-3940
IS - 1
M1 - 1
ER -
