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Cinacalcet does not affect longitudinal growth but increases body weight gain in experimental uraemia

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Cinacalcet does not affect longitudinal growth but increases body weight gain in experimental uraemia. / Nakagawa, Kumiko; Pérez, Eduardo C; Oh, Jun; Santos, Fernando; Geldyyev, Aman; Gross, Marie-L; Schaefer, Franz; Schmitt, Claus P.

in: NEPHROL DIAL TRANSPL, Jahrgang 23, Nr. 9, 09.2008, S. 2761-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Nakagawa, K, Pérez, EC, Oh, J, Santos, F, Geldyyev, A, Gross, M-L, Schaefer, F & Schmitt, CP 2008, 'Cinacalcet does not affect longitudinal growth but increases body weight gain in experimental uraemia', NEPHROL DIAL TRANSPL, Jg. 23, Nr. 9, S. 2761-7. https://doi.org/10.1093/ndt/gfn143

APA

Nakagawa, K., Pérez, E. C., Oh, J., Santos, F., Geldyyev, A., Gross, M-L., Schaefer, F., & Schmitt, C. P. (2008). Cinacalcet does not affect longitudinal growth but increases body weight gain in experimental uraemia. NEPHROL DIAL TRANSPL, 23(9), 2761-7. https://doi.org/10.1093/ndt/gfn143

Vancouver

Nakagawa K, Pérez EC, Oh J, Santos F, Geldyyev A, Gross M-L et al. Cinacalcet does not affect longitudinal growth but increases body weight gain in experimental uraemia. NEPHROL DIAL TRANSPL. 2008 Sep;23(9):2761-7. https://doi.org/10.1093/ndt/gfn143

Bibtex

@article{6034af245d444407beef0980e7a39c34,
title = "Cinacalcet does not affect longitudinal growth but increases body weight gain in experimental uraemia",
abstract = "BACKGROUND: Cinacalcet (CIN) efficiently suppresses parathyroid hormone (PTH) secretion by the activation of the calcium-sensing receptor (CaR). Epiphyseal chondrocytes also express the CaR and its activation promotes cell proliferation and differentiation in vitro. Hence, the impact of CIN on the growth plate function requires assessment before routine administration in children.METHODS: We treated subtotally nephrectomized (SNX) and sham-operated, ad lib and pair-fed Sprague-Dawley rats with CIN (15 mg/kg day) or solvent (S) for 14 days p.o. and assessed whole body and tibia length gain, growth plate morphology, osseous front advance (OFA) (calcein staining) and chondrocyte proliferation rate [5-bromo-2'-deoxyuridine (BrdU) staining].RESULTS: Total body length gain did not differ after 7 and 14 days (SNX + CIN 2.9 +/- 0.6, SNX + S 3.0 +/- 0.7; sham + CIN 4.2 +/- 0.4, sham + S 4.5 +/- 0.4; sham pair-fed + CIN 3.3 +/- 0.5, sham pair-fed + S 3.5 +/- 0.6 cm/14 days; P = n.s.). Tibia length, the height of the total growth plate and the hypertrophic zone, OFA and chondrocyte proliferation rate were similar with CIN and S. Serum Ca(2+) declined with CIN treatment; PTH was 61% lower in CIN- compared to S-treated SNX (P < 0.05). Food intake was similar, whereas body weight gain (21.6 +/- 8.7 versus 12.7 +/- 11.2 g) and body weight gain per food intake (141 +/- 50 versus 77 +/- 70 g/kg) improved in CIN- versus S-treated SNX animals (P < 0.05).CONCLUSION: CIN treatment does not impact on growth plate chondrocyte function in uraemic rats, but improves food efficiency and body weight gain.",
keywords = "Animals, Biometry, Cell Proliferation, Chondrocytes/cytology, Cinacalcet, Growth Plate/drug effects, Immunohistochemistry, Male, Naphthalenes/pharmacology, Rats, Rats, Sprague-Dawley/anatomy & histology, Uremia/physiopathology, Weight Gain/drug effects",
author = "Kumiko Nakagawa and P{\'e}rez, {Eduardo C} and Jun Oh and Fernando Santos and Aman Geldyyev and Marie-L Gross and Franz Schaefer and Schmitt, {Claus P}",
year = "2008",
month = sep,
doi = "10.1093/ndt/gfn143",
language = "English",
volume = "23",
pages = "2761--7",
journal = "NEPHROL DIAL TRANSPL",
issn = "0931-0509",
publisher = "Oxford University Press",
number = "9",

}

RIS

TY - JOUR

T1 - Cinacalcet does not affect longitudinal growth but increases body weight gain in experimental uraemia

AU - Nakagawa, Kumiko

AU - Pérez, Eduardo C

AU - Oh, Jun

AU - Santos, Fernando

AU - Geldyyev, Aman

AU - Gross, Marie-L

AU - Schaefer, Franz

AU - Schmitt, Claus P

PY - 2008/9

Y1 - 2008/9

N2 - BACKGROUND: Cinacalcet (CIN) efficiently suppresses parathyroid hormone (PTH) secretion by the activation of the calcium-sensing receptor (CaR). Epiphyseal chondrocytes also express the CaR and its activation promotes cell proliferation and differentiation in vitro. Hence, the impact of CIN on the growth plate function requires assessment before routine administration in children.METHODS: We treated subtotally nephrectomized (SNX) and sham-operated, ad lib and pair-fed Sprague-Dawley rats with CIN (15 mg/kg day) or solvent (S) for 14 days p.o. and assessed whole body and tibia length gain, growth plate morphology, osseous front advance (OFA) (calcein staining) and chondrocyte proliferation rate [5-bromo-2'-deoxyuridine (BrdU) staining].RESULTS: Total body length gain did not differ after 7 and 14 days (SNX + CIN 2.9 +/- 0.6, SNX + S 3.0 +/- 0.7; sham + CIN 4.2 +/- 0.4, sham + S 4.5 +/- 0.4; sham pair-fed + CIN 3.3 +/- 0.5, sham pair-fed + S 3.5 +/- 0.6 cm/14 days; P = n.s.). Tibia length, the height of the total growth plate and the hypertrophic zone, OFA and chondrocyte proliferation rate were similar with CIN and S. Serum Ca(2+) declined with CIN treatment; PTH was 61% lower in CIN- compared to S-treated SNX (P < 0.05). Food intake was similar, whereas body weight gain (21.6 +/- 8.7 versus 12.7 +/- 11.2 g) and body weight gain per food intake (141 +/- 50 versus 77 +/- 70 g/kg) improved in CIN- versus S-treated SNX animals (P < 0.05).CONCLUSION: CIN treatment does not impact on growth plate chondrocyte function in uraemic rats, but improves food efficiency and body weight gain.

AB - BACKGROUND: Cinacalcet (CIN) efficiently suppresses parathyroid hormone (PTH) secretion by the activation of the calcium-sensing receptor (CaR). Epiphyseal chondrocytes also express the CaR and its activation promotes cell proliferation and differentiation in vitro. Hence, the impact of CIN on the growth plate function requires assessment before routine administration in children.METHODS: We treated subtotally nephrectomized (SNX) and sham-operated, ad lib and pair-fed Sprague-Dawley rats with CIN (15 mg/kg day) or solvent (S) for 14 days p.o. and assessed whole body and tibia length gain, growth plate morphology, osseous front advance (OFA) (calcein staining) and chondrocyte proliferation rate [5-bromo-2'-deoxyuridine (BrdU) staining].RESULTS: Total body length gain did not differ after 7 and 14 days (SNX + CIN 2.9 +/- 0.6, SNX + S 3.0 +/- 0.7; sham + CIN 4.2 +/- 0.4, sham + S 4.5 +/- 0.4; sham pair-fed + CIN 3.3 +/- 0.5, sham pair-fed + S 3.5 +/- 0.6 cm/14 days; P = n.s.). Tibia length, the height of the total growth plate and the hypertrophic zone, OFA and chondrocyte proliferation rate were similar with CIN and S. Serum Ca(2+) declined with CIN treatment; PTH was 61% lower in CIN- compared to S-treated SNX (P < 0.05). Food intake was similar, whereas body weight gain (21.6 +/- 8.7 versus 12.7 +/- 11.2 g) and body weight gain per food intake (141 +/- 50 versus 77 +/- 70 g/kg) improved in CIN- versus S-treated SNX animals (P < 0.05).CONCLUSION: CIN treatment does not impact on growth plate chondrocyte function in uraemic rats, but improves food efficiency and body weight gain.

KW - Animals

KW - Biometry

KW - Cell Proliferation

KW - Chondrocytes/cytology

KW - Cinacalcet

KW - Growth Plate/drug effects

KW - Immunohistochemistry

KW - Male

KW - Naphthalenes/pharmacology

KW - Rats

KW - Rats, Sprague-Dawley/anatomy & histology

KW - Uremia/physiopathology

KW - Weight Gain/drug effects

U2 - 10.1093/ndt/gfn143

DO - 10.1093/ndt/gfn143

M3 - SCORING: Journal article

C2 - 18408076

VL - 23

SP - 2761

EP - 2767

JO - NEPHROL DIAL TRANSPL

JF - NEPHROL DIAL TRANSPL

SN - 0931-0509

IS - 9

ER -