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Cidea improves the metabolic profile through expansion of adipose tissue

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Cidea improves the metabolic profile through expansion of adipose tissue. / Abreu-Vieira, Gustavo; Fischer, Alexander W; Mattsson, Charlotte; de Jong, Jasper M A; Shabalina, Irina G; Rydén, Mikael; Laurencikiene, Jurga; Arner, Peter; Cannon, Barbara; Nedergaard, Jan; Petrovic, Natasa.

in: NAT COMMUN, Jahrgang 6, 06.2015, S. Art. 7433.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Abreu-Vieira, G, Fischer, AW, Mattsson, C, de Jong, JMA, Shabalina, IG, Rydén, M, Laurencikiene, J, Arner, P, Cannon, B, Nedergaard, J & Petrovic, N 2015, 'Cidea improves the metabolic profile through expansion of adipose tissue', NAT COMMUN, Jg. 6, S. Art. 7433. https://doi.org/10.1038/ncomms8433

APA

Abreu-Vieira, G., Fischer, A. W., Mattsson, C., de Jong, J. M. A., Shabalina, I. G., Rydén, M., Laurencikiene, J., Arner, P., Cannon, B., Nedergaard, J., & Petrovic, N. (2015). Cidea improves the metabolic profile through expansion of adipose tissue. NAT COMMUN, 6, Art. 7433. https://doi.org/10.1038/ncomms8433

Vancouver

Abreu-Vieira G, Fischer AW, Mattsson C, de Jong JMA, Shabalina IG, Rydén M et al. Cidea improves the metabolic profile through expansion of adipose tissue. NAT COMMUN. 2015 Jun;6:Art. 7433. https://doi.org/10.1038/ncomms8433

Bibtex

@article{ab0c7f2df9674c5faeaeae0392d8f415,
title = "Cidea improves the metabolic profile through expansion of adipose tissue",
abstract = "In humans, Cidea (cell death-inducing DNA fragmentation factor alpha-like effector A) is highly but variably expressed in white fat, and expression correlates with metabolic health. Here we generate transgenic mice expressing human Cidea in adipose tissues (aP2-hCidea mice) and show that Cidea is mechanistically associated with a robust increase in adipose tissue expandability. Under humanized conditions (thermoneutrality, mature age and prolonged exposure to high-fat diet), aP2-hCidea mice develop a much more pronounced obesity than their wild-type littermates. Remarkably, the malfunctioning of visceral fat normally caused by massive obesity is fully overcome-perilipin 1 and Akt expression are preserved, tissue degradation is prevented, macrophage accumulation is decreased and adiponectin expression remains high. Importantly, the aP2-hCidea mice display enhanced insulin sensitivity. Our data establish a functional role for Cidea and suggest that, in humans, the association between Cidea levels in white fat and metabolic health is not only correlative but also causative.",
author = "Gustavo Abreu-Vieira and Fischer, {Alexander W} and Charlotte Mattsson and {de Jong}, {Jasper M A} and Shabalina, {Irina G} and Mikael Ryd{\'e}n and Jurga Laurencikiene and Peter Arner and Barbara Cannon and Jan Nedergaard and Natasa Petrovic",
year = "2015",
month = jun,
doi = "10.1038/ncomms8433",
language = "English",
volume = "6",
pages = "Art. 7433",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Cidea improves the metabolic profile through expansion of adipose tissue

AU - Abreu-Vieira, Gustavo

AU - Fischer, Alexander W

AU - Mattsson, Charlotte

AU - de Jong, Jasper M A

AU - Shabalina, Irina G

AU - Rydén, Mikael

AU - Laurencikiene, Jurga

AU - Arner, Peter

AU - Cannon, Barbara

AU - Nedergaard, Jan

AU - Petrovic, Natasa

PY - 2015/6

Y1 - 2015/6

N2 - In humans, Cidea (cell death-inducing DNA fragmentation factor alpha-like effector A) is highly but variably expressed in white fat, and expression correlates with metabolic health. Here we generate transgenic mice expressing human Cidea in adipose tissues (aP2-hCidea mice) and show that Cidea is mechanistically associated with a robust increase in adipose tissue expandability. Under humanized conditions (thermoneutrality, mature age and prolonged exposure to high-fat diet), aP2-hCidea mice develop a much more pronounced obesity than their wild-type littermates. Remarkably, the malfunctioning of visceral fat normally caused by massive obesity is fully overcome-perilipin 1 and Akt expression are preserved, tissue degradation is prevented, macrophage accumulation is decreased and adiponectin expression remains high. Importantly, the aP2-hCidea mice display enhanced insulin sensitivity. Our data establish a functional role for Cidea and suggest that, in humans, the association between Cidea levels in white fat and metabolic health is not only correlative but also causative.

AB - In humans, Cidea (cell death-inducing DNA fragmentation factor alpha-like effector A) is highly but variably expressed in white fat, and expression correlates with metabolic health. Here we generate transgenic mice expressing human Cidea in adipose tissues (aP2-hCidea mice) and show that Cidea is mechanistically associated with a robust increase in adipose tissue expandability. Under humanized conditions (thermoneutrality, mature age and prolonged exposure to high-fat diet), aP2-hCidea mice develop a much more pronounced obesity than their wild-type littermates. Remarkably, the malfunctioning of visceral fat normally caused by massive obesity is fully overcome-perilipin 1 and Akt expression are preserved, tissue degradation is prevented, macrophage accumulation is decreased and adiponectin expression remains high. Importantly, the aP2-hCidea mice display enhanced insulin sensitivity. Our data establish a functional role for Cidea and suggest that, in humans, the association between Cidea levels in white fat and metabolic health is not only correlative but also causative.

U2 - 10.1038/ncomms8433

DO - 10.1038/ncomms8433

M3 - SCORING: Journal article

C2 - 26118629

VL - 6

SP - Art. 7433

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

ER -