PortalPublikationenChronic Hepatitis E is associated with cholangitis

Chronic Hepatitis E is associated with cholangitis

Standard

Chronic Hepatitis E is associated with cholangitis. / Beer, Andrea; Holzmann, Heidemarie; Pischke, Sven; Behrendt, Patrick; Wrba, Fritz; Schlue, Jerome; Drebber, Uta; Neudert, Barbara; Halilbasic, Emina; Kreipe, Hans; Lohse, Ansgar; Sterneck, Martina; Wedemeyer, Heiner; Manns, Michael; Dienes, Hans P.

in: LIVER INT, Jahrgang 39, Nr. 10, 10.2019, S. 1876-1883.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung

Harvard

Beer, A, Holzmann, H, Pischke, S, Behrendt, P, Wrba, F, Schlue, J, Drebber, U, Neudert, B, Halilbasic, E, Kreipe, H, Lohse, A, Sterneck, M, Wedemeyer, H, Manns, M & Dienes, HP 2019, 'Chronic Hepatitis E is associated with cholangitis', LIVER INT, Jg. 39, Nr. 10, S. 1876-1883. https://doi.org/10.1111/liv.14137

APA

Beer, A., Holzmann, H., Pischke, S., Behrendt, P., Wrba, F., Schlue, J., Drebber, U., Neudert, B., Halilbasic, E., Kreipe, H., Lohse, A., Sterneck, M., Wedemeyer, H., Manns, M., & Dienes, H. P. (2019). Chronic Hepatitis E is associated with cholangitis. LIVER INT, 39(10), 1876-1883. https://doi.org/10.1111/liv.14137

Vancouver

Beer A, Holzmann H, Pischke S, Behrendt P, Wrba F, Schlue J et al. Chronic Hepatitis E is associated with cholangitis. LIVER INT. 2019 Okt;39(10):1876-1883. https://doi.org/10.1111/liv.14137

Bibtex

@article{28da5ca0debf46b28631e616f32d360f,
title = "Chronic Hepatitis E is associated with cholangitis",
abstract = "BACKGROUND AND AIMS: Sporadic hepatitis E is an emerging indigenous disease in Europe induced by genotype 3 of the virus. While the disease takes an acute self-limited course in immunocompetent individuals, under immunocompromised conditions chronic hepatitis E might develop. The histology of chronic hepatitis E has not been described in detail systematically.METHODS: Liver biopsies from 19 immunosuppressed patients with chronic hepatitis E were collected: 17 were organ transplant recipients, one had a CD4-deficiency and one had received steroid therapy because of ulcerative colitis. Biopsies were processed with standard stains. Evaluation of histologic activity and fibrosis was performed according to Ishak. Additionally, immunohistochemistry with antibodies directed against open reading frame 2 and 3 of the virus was performed and liver biopsies were tested for hepatitis E virus RNA.RESULTS: Biochemical data showed an increase in alanine transaminase, aspartate transaminase, gamma-glutamyl transferase and total bilirubin. Histopathology displayed typical features of chronic hepatitis with mild to moderate activity. The number of polymorphonuclear leucocytes was considerably increased and all patients had a florid cholangitis that presented as a destructive form in five of them. Hepatocytes and bile duct epithelia stained positive for hepatitis E virus by immunohistochemistry.CONCLUSIONS: Chronic hepatitis E in immunocompromised individuals runs a similar course as hepatitis B and C and shows similar histopathology. However, the presence of destructive cholangitis in some cases accompanied by an increased number of polymorphonuclear leucocytes is markedly different. Immunohistochemically the virus is present in bile duct epithelia, seemingly the cause for cholangitis.",
author = "Andrea Beer and Heidemarie Holzmann and Sven Pischke and Patrick Behrendt and Fritz Wrba and Jerome Schlue and Uta Drebber and Barbara Neudert and Emina Halilbasic and Hans Kreipe and Ansgar Lohse and Martina Sterneck and Heiner Wedemeyer and Michael Manns and Dienes, {Hans P}",
note = "{\textcopyright} 2019 The Authors. Liver International published by John Wiley & Sons Ltd.",
year = "2019",
month = oct,
doi = "10.1111/liv.14137",
language = "English",
volume = "39",
pages = "1876--1883",
journal = "LIVER INT",
issn = "1478-3223",
publisher = "Wiley-Blackwell",
number = "10",

}

RIS

TY - JOUR

T1 - Chronic Hepatitis E is associated with cholangitis

AU - Beer, Andrea

AU - Holzmann, Heidemarie

AU - Pischke, Sven

AU - Behrendt, Patrick

AU - Wrba, Fritz

AU - Schlue, Jerome

AU - Drebber, Uta

AU - Neudert, Barbara

AU - Halilbasic, Emina

AU - Kreipe, Hans

AU - Lohse, Ansgar

AU - Sterneck, Martina

AU - Wedemeyer, Heiner

AU - Manns, Michael

AU - Dienes, Hans P

N1 - © 2019 The Authors. Liver International published by John Wiley & Sons Ltd.

PY - 2019/10

Y1 - 2019/10

N2 - BACKGROUND AND AIMS: Sporadic hepatitis E is an emerging indigenous disease in Europe induced by genotype 3 of the virus. While the disease takes an acute self-limited course in immunocompetent individuals, under immunocompromised conditions chronic hepatitis E might develop. The histology of chronic hepatitis E has not been described in detail systematically.METHODS: Liver biopsies from 19 immunosuppressed patients with chronic hepatitis E were collected: 17 were organ transplant recipients, one had a CD4-deficiency and one had received steroid therapy because of ulcerative colitis. Biopsies were processed with standard stains. Evaluation of histologic activity and fibrosis was performed according to Ishak. Additionally, immunohistochemistry with antibodies directed against open reading frame 2 and 3 of the virus was performed and liver biopsies were tested for hepatitis E virus RNA.RESULTS: Biochemical data showed an increase in alanine transaminase, aspartate transaminase, gamma-glutamyl transferase and total bilirubin. Histopathology displayed typical features of chronic hepatitis with mild to moderate activity. The number of polymorphonuclear leucocytes was considerably increased and all patients had a florid cholangitis that presented as a destructive form in five of them. Hepatocytes and bile duct epithelia stained positive for hepatitis E virus by immunohistochemistry.CONCLUSIONS: Chronic hepatitis E in immunocompromised individuals runs a similar course as hepatitis B and C and shows similar histopathology. However, the presence of destructive cholangitis in some cases accompanied by an increased number of polymorphonuclear leucocytes is markedly different. Immunohistochemically the virus is present in bile duct epithelia, seemingly the cause for cholangitis.

AB - BACKGROUND AND AIMS: Sporadic hepatitis E is an emerging indigenous disease in Europe induced by genotype 3 of the virus. While the disease takes an acute self-limited course in immunocompetent individuals, under immunocompromised conditions chronic hepatitis E might develop. The histology of chronic hepatitis E has not been described in detail systematically.METHODS: Liver biopsies from 19 immunosuppressed patients with chronic hepatitis E were collected: 17 were organ transplant recipients, one had a CD4-deficiency and one had received steroid therapy because of ulcerative colitis. Biopsies were processed with standard stains. Evaluation of histologic activity and fibrosis was performed according to Ishak. Additionally, immunohistochemistry with antibodies directed against open reading frame 2 and 3 of the virus was performed and liver biopsies were tested for hepatitis E virus RNA.RESULTS: Biochemical data showed an increase in alanine transaminase, aspartate transaminase, gamma-glutamyl transferase and total bilirubin. Histopathology displayed typical features of chronic hepatitis with mild to moderate activity. The number of polymorphonuclear leucocytes was considerably increased and all patients had a florid cholangitis that presented as a destructive form in five of them. Hepatocytes and bile duct epithelia stained positive for hepatitis E virus by immunohistochemistry.CONCLUSIONS: Chronic hepatitis E in immunocompromised individuals runs a similar course as hepatitis B and C and shows similar histopathology. However, the presence of destructive cholangitis in some cases accompanied by an increased number of polymorphonuclear leucocytes is markedly different. Immunohistochemically the virus is present in bile duct epithelia, seemingly the cause for cholangitis.

U2 - 10.1111/liv.14137

DO - 10.1111/liv.14137

M3 - SCORING: Journal article

C2 - 31102493

VL - 39

SP - 1876

EP - 1883

JO - LIVER INT

JF - LIVER INT

SN - 1478-3223

IS - 10

ER -