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Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage

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Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage. / Ho, Kim Hoa; Candat, Adrien; Scarpetta, Valentina; Faucourt, Marion; Weill, Solene; Salio, Chiara; D'Este, Elisa; Meschkat, Martin; Wurm, Christian A; Kneussel, Matthias; Janke, Carsten; Magiera, Maria M; Genovesio, Auguste; Meunier, Alice; Sassoè-Pognetto, Marco; Brill, Monika S; Spassky, Nathalie; Patrizi, Annarita.

in: DEV CELL, Jahrgang 58, Nr. 23, 04.12.2023, S. 2641-2651.e6.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › Kurzpublikation › Forschung › Begutachtung

Harvard

Ho, KH, Candat, A, Scarpetta, V, Faucourt, M, Weill, S, Salio, C, D'Este, E, Meschkat, M, Wurm, CA, Kneussel, M, Janke, C, Magiera, MM, Genovesio, A, Meunier, A, Sassoè-Pognetto, M, Brill, MS, Spassky, N & Patrizi, A 2023, 'Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage', DEV CELL, Jg. 58, Nr. 23, S. 2641-2651.e6. https://doi.org/10.1016/j.devcel.2023.10.003

APA

Ho, K. H., Candat, A., Scarpetta, V., Faucourt, M., Weill, S., Salio, C., D'Este, E., Meschkat, M., Wurm, C. A., Kneussel, M., Janke, C., Magiera, M. M., Genovesio, A., Meunier, A., Sassoè-Pognetto, M., Brill, M. S., Spassky, N., & Patrizi, A. (2023). Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage. DEV CELL, 58(23), 2641-2651.e6. https://doi.org/10.1016/j.devcel.2023.10.003

Vancouver

Ho KH, Candat A, Scarpetta V, Faucourt M, Weill S, Salio C et al. Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage. DEV CELL. 2023 Dez 4;58(23):2641-2651.e6. https://doi.org/10.1016/j.devcel.2023.10.003

Bibtex

@article{b540a6c5adec4e1781ac544d7f76fa0e,
title = "Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage",
abstract = "Choroid plexuses (ChPs) produce cerebrospinal fluid and sense non-cell-autonomous stimuli to control the homeostasis of the central nervous system. They are mainly composed of epithelial multiciliated cells, whose development and function are still controversial. We have thus characterized the stepwise order of mammalian ChP epithelia cilia formation using a combination of super-resolution-microscopy approaches and mouse genetics. We show that ChP ciliated cells are built embryonically on a treadmill of spatiotemporally regulated events, starting with atypical centriole amplification and ending with the construction of nodal-like 9+0 cilia, characterized by both primary and motile features. ChP cilia undergo axoneme resorption at early postnatal stages through a microtubule destabilization process controlled by the microtubule-severing enzyme spastin and mitigated by polyglutamylation levels. Notably, this phenotype is preserved in humans, suggesting a conserved ciliary resorption mechanism in mammals.",
keywords = "Humans, Mice, Animals, Axoneme, Cilia/physiology, Epithelial Cells/physiology, Epithelium, Choroid, Mammals",
author = "Ho, {Kim Hoa} and Adrien Candat and Valentina Scarpetta and Marion Faucourt and Solene Weill and Chiara Salio and Elisa D'Este and Martin Meschkat and Wurm, {Christian A} and Matthias Kneussel and Carsten Janke and Magiera, {Maria M} and Auguste Genovesio and Alice Meunier and Marco Sasso{\`e}-Pognetto and Brill, {Monika S} and Nathalie Spassky and Annarita Patrizi",
note = "Copyright {\textcopyright} 2023 Elsevier Inc. All rights reserved.",
year = "2023",
month = dec,
day = "4",
doi = "10.1016/j.devcel.2023.10.003",
language = "English",
volume = "58",
pages = "2641--2651.e6",
journal = "DEV CELL",
issn = "1534-5807",
publisher = "Cell Press",
number = "23",

}

RIS

TY - JOUR

T1 - Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage

AU - Ho, Kim Hoa

AU - Candat, Adrien

AU - Scarpetta, Valentina

AU - Faucourt, Marion

AU - Weill, Solene

AU - Salio, Chiara

AU - D'Este, Elisa

AU - Meschkat, Martin

AU - Wurm, Christian A

AU - Kneussel, Matthias

AU - Janke, Carsten

AU - Magiera, Maria M

AU - Genovesio, Auguste

AU - Meunier, Alice

AU - Sassoè-Pognetto, Marco

AU - Brill, Monika S

AU - Spassky, Nathalie

AU - Patrizi, Annarita

N1 - Copyright © 2023 Elsevier Inc. All rights reserved.

PY - 2023/12/4

Y1 - 2023/12/4

N2 - Choroid plexuses (ChPs) produce cerebrospinal fluid and sense non-cell-autonomous stimuli to control the homeostasis of the central nervous system. They are mainly composed of epithelial multiciliated cells, whose development and function are still controversial. We have thus characterized the stepwise order of mammalian ChP epithelia cilia formation using a combination of super-resolution-microscopy approaches and mouse genetics. We show that ChP ciliated cells are built embryonically on a treadmill of spatiotemporally regulated events, starting with atypical centriole amplification and ending with the construction of nodal-like 9+0 cilia, characterized by both primary and motile features. ChP cilia undergo axoneme resorption at early postnatal stages through a microtubule destabilization process controlled by the microtubule-severing enzyme spastin and mitigated by polyglutamylation levels. Notably, this phenotype is preserved in humans, suggesting a conserved ciliary resorption mechanism in mammals.

AB - Choroid plexuses (ChPs) produce cerebrospinal fluid and sense non-cell-autonomous stimuli to control the homeostasis of the central nervous system. They are mainly composed of epithelial multiciliated cells, whose development and function are still controversial. We have thus characterized the stepwise order of mammalian ChP epithelia cilia formation using a combination of super-resolution-microscopy approaches and mouse genetics. We show that ChP ciliated cells are built embryonically on a treadmill of spatiotemporally regulated events, starting with atypical centriole amplification and ending with the construction of nodal-like 9+0 cilia, characterized by both primary and motile features. ChP cilia undergo axoneme resorption at early postnatal stages through a microtubule destabilization process controlled by the microtubule-severing enzyme spastin and mitigated by polyglutamylation levels. Notably, this phenotype is preserved in humans, suggesting a conserved ciliary resorption mechanism in mammals.

KW - Humans

KW - Mice

KW - Animals

KW - Axoneme

KW - Cilia/physiology

KW - Epithelial Cells/physiology

KW - Epithelium

KW - Choroid

KW - Mammals

U2 - 10.1016/j.devcel.2023.10.003

DO - 10.1016/j.devcel.2023.10.003

M3 - Short publication

C2 - 37890489

VL - 58

SP - 2641-2651.e6

JO - DEV CELL

JF - DEV CELL

SN - 1534-5807

IS - 23

ER -