Chorioidale Neovaskularisation bei membranoproliferativer Glomerulonephritis Typ II, die photodynamische Therapie als Therapieoption - Eine Kasuistik

TY - JOUR

T1 - Chorioidale Neovaskularisation bei membranoproliferativer Glomerulonephritis Typ II, die photodynamische Therapie als Therapieoption - Eine Kasuistik

AU - Hassenstein, Andrea

AU - Richard, Gisbert

PY - 2003/7/1

Y1 - 2003/7/1

N2 - BACKGROUND: Photodynamic therapy (PDT) is an established treatment in predominantly classic choroidal neovascularisation (CNV) in exudative age-related macular degeneration (AMD). Membranoproliferative glomerulonephritis (MPGN) type II leads to AMD-similar changes ("pseudo-AMD") of the fundus with CNV as a late complication. We report on a patient suffering from MPGN II and a classic CNV who was treated with PDT.PATIENT AND METHOD: A 31-year old male patient suffering from MPGN II from the age of 8 presented with visual deterioration and metamorphopsies on his left eye (VA OD 1.0, OS 0.25). Funduscopy revealed a "Pseudo"-AMD on both eyes and the left eye showed a 100 % classic CNV in fluorescein angiography (FLA). The left eye has treated with PDT. Visual acuity after PDT remained stable with 0.25 OS and metamorphopsies were reduced. 3 months later FLA showed a small residual leakage, therefore a second PDT was performed. 4 months after the 2 nd PDT the patient suffered again from metamorphopsies with a stable VA of 0.25 OS following a 3 rd PDT.RESULTS: Visual acuity of the left eye remained stable at 0.25 and metamorphopsies reduced due to the treatment of 3 PDT's. Even in "pseudo-AMD" in MPGN II the PDT is able to reduce leakage and stops progression consistent to the results in exudative AMD.CONCLUSION: In MPGN II associated "pseudo"-AMD with classic CNV the PDT was also successful. The origin of the CNV does not appear to play a role for the success of the PDT.

AB - BACKGROUND: Photodynamic therapy (PDT) is an established treatment in predominantly classic choroidal neovascularisation (CNV) in exudative age-related macular degeneration (AMD). Membranoproliferative glomerulonephritis (MPGN) type II leads to AMD-similar changes ("pseudo-AMD") of the fundus with CNV as a late complication. We report on a patient suffering from MPGN II and a classic CNV who was treated with PDT.PATIENT AND METHOD: A 31-year old male patient suffering from MPGN II from the age of 8 presented with visual deterioration and metamorphopsies on his left eye (VA OD 1.0, OS 0.25). Funduscopy revealed a "Pseudo"-AMD on both eyes and the left eye showed a 100 % classic CNV in fluorescein angiography (FLA). The left eye has treated with PDT. Visual acuity after PDT remained stable with 0.25 OS and metamorphopsies were reduced. 3 months later FLA showed a small residual leakage, therefore a second PDT was performed. 4 months after the 2 nd PDT the patient suffered again from metamorphopsies with a stable VA of 0.25 OS following a 3 rd PDT.RESULTS: Visual acuity of the left eye remained stable at 0.25 and metamorphopsies reduced due to the treatment of 3 PDT's. Even in "pseudo-AMD" in MPGN II the PDT is able to reduce leakage and stops progression consistent to the results in exudative AMD.CONCLUSION: In MPGN II associated "pseudo"-AMD with classic CNV the PDT was also successful. The origin of the CNV does not appear to play a role for the success of the PDT.

KW - Adult

KW - Blood-Retinal Barrier

KW - Choroidal Neovascularization

KW - Fluorescein Angiography

KW - Follow-Up Studies

KW - Fundus Oculi

KW - Glomerulonephritis, Membranoproliferative

KW - Humans

KW - Macular Degeneration

KW - Male

KW - Photochemotherapy

KW - Recurrence

KW - Retreatment

U2 - 10.1055/s-2003-40937

DO - 10.1055/s-2003-40937

M3 - SCORING: Zeitschriftenaufsatz

C2 - 12886510

VL - 220

SP - 492

EP - 495

JO - KLIN MONATSBL AUGENH

JF - KLIN MONATSBL AUGENH

SN - 0023-2165

IS - 7

ER -