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CHL1 and NrCAM are Primarily Expressed in Low Grade Pediatric Neuroblastoma

Standard

CHL1 and NrCAM are Primarily Expressed in Low Grade Pediatric Neuroblastoma. / Wachowiak, Robin; Mayer, Steffi; Suttkus, Anne; Martynov, Illya; Lacher, Martin; Melling, Nathaniel; Izbicki, Jakob R; Tachezy, Michael.

in: OPEN MED-WARSAW, Jahrgang 14, 2019, S. 920-927.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wachowiak, R, Mayer, S, Suttkus, A, Martynov, I, Lacher, M, Melling, N, Izbicki, JR & Tachezy, M 2019, 'CHL1 and NrCAM are Primarily Expressed in Low Grade Pediatric Neuroblastoma', OPEN MED-WARSAW, Jg. 14, S. 920-927. https://doi.org/10.1515/med-2019-0109

APA

Wachowiak, R., Mayer, S., Suttkus, A., Martynov, I., Lacher, M., Melling, N., Izbicki, J. R., & Tachezy, M. (2019). CHL1 and NrCAM are Primarily Expressed in Low Grade Pediatric Neuroblastoma. OPEN MED-WARSAW, 14, 920-927. https://doi.org/10.1515/med-2019-0109

Vancouver

Wachowiak R, Mayer S, Suttkus A, Martynov I, Lacher M, Melling N et al. CHL1 and NrCAM are Primarily Expressed in Low Grade Pediatric Neuroblastoma. OPEN MED-WARSAW. 2019;14:920-927. https://doi.org/10.1515/med-2019-0109

Bibtex

@article{7daad4f555de4318b83ca510dd6dcdf2,
title = "CHL1 and NrCAM are Primarily Expressed in Low Grade Pediatric Neuroblastoma",
abstract = "Background: Neural cell adhesion molecules like close homolog of L1 protein (CHL1) and neuronal glia related cell adhesion molecule (NrCAM) play an important role in development and regeneration of the central nervous system. However, they are also associated with cancerogenesis and progression in adult malignancies, thus gain increasing importance in cancer research. We therefore studied the expression of CHL1 and NrCAM according to the course of disease in children with neuroblastoma.Methods: CHL1 and NrCAM expression levels were histologically assessed by tissue microarrays from surgically resected neuroblastoma specimens of 56 children. Expression of both markers was correlated to demographics as well as clinical data including metastatic dissemination and survival.Results: CHL1 was expressed in 9% and NrCAM in 51% of neuroblastoma tissue samples. Expression of CHL1 was higher in patients with low Hughes grade 1a/b (p=0.01). NrCAM was more often detected in patients with a low International Staging System (INSS) score 1/2 (p=0.04).Conclusion: CHL1 and NrCAM expression was associated with low-grade pediatric neuroblastoma. These adhesion molecules may play a role in early tumor development of neuroblastoma.",
author = "Robin Wachowiak and Steffi Mayer and Anne Suttkus and Illya Martynov and Martin Lacher and Nathaniel Melling and Izbicki, {Jakob R} and Michael Tachezy",
note = "{\textcopyright} 2019 Robin Wachowiak et al., published by De Gruyter.",
year = "2019",
doi = "10.1515/med-2019-0109",
language = "English",
volume = "14",
pages = "920--927",
journal = "OPEN MED-WARSAW",
issn = "2391-5463",
publisher = "Walter De Gruyter",

}

RIS

TY - JOUR

T1 - CHL1 and NrCAM are Primarily Expressed in Low Grade Pediatric Neuroblastoma

AU - Wachowiak, Robin

AU - Mayer, Steffi

AU - Suttkus, Anne

AU - Martynov, Illya

AU - Lacher, Martin

AU - Melling, Nathaniel

AU - Izbicki, Jakob R

AU - Tachezy, Michael

N1 - © 2019 Robin Wachowiak et al., published by De Gruyter.

PY - 2019

Y1 - 2019

N2 - Background: Neural cell adhesion molecules like close homolog of L1 protein (CHL1) and neuronal glia related cell adhesion molecule (NrCAM) play an important role in development and regeneration of the central nervous system. However, they are also associated with cancerogenesis and progression in adult malignancies, thus gain increasing importance in cancer research. We therefore studied the expression of CHL1 and NrCAM according to the course of disease in children with neuroblastoma.Methods: CHL1 and NrCAM expression levels were histologically assessed by tissue microarrays from surgically resected neuroblastoma specimens of 56 children. Expression of both markers was correlated to demographics as well as clinical data including metastatic dissemination and survival.Results: CHL1 was expressed in 9% and NrCAM in 51% of neuroblastoma tissue samples. Expression of CHL1 was higher in patients with low Hughes grade 1a/b (p=0.01). NrCAM was more often detected in patients with a low International Staging System (INSS) score 1/2 (p=0.04).Conclusion: CHL1 and NrCAM expression was associated with low-grade pediatric neuroblastoma. These adhesion molecules may play a role in early tumor development of neuroblastoma.

AB - Background: Neural cell adhesion molecules like close homolog of L1 protein (CHL1) and neuronal glia related cell adhesion molecule (NrCAM) play an important role in development and regeneration of the central nervous system. However, they are also associated with cancerogenesis and progression in adult malignancies, thus gain increasing importance in cancer research. We therefore studied the expression of CHL1 and NrCAM according to the course of disease in children with neuroblastoma.Methods: CHL1 and NrCAM expression levels were histologically assessed by tissue microarrays from surgically resected neuroblastoma specimens of 56 children. Expression of both markers was correlated to demographics as well as clinical data including metastatic dissemination and survival.Results: CHL1 was expressed in 9% and NrCAM in 51% of neuroblastoma tissue samples. Expression of CHL1 was higher in patients with low Hughes grade 1a/b (p=0.01). NrCAM was more often detected in patients with a low International Staging System (INSS) score 1/2 (p=0.04).Conclusion: CHL1 and NrCAM expression was associated with low-grade pediatric neuroblastoma. These adhesion molecules may play a role in early tumor development of neuroblastoma.

U2 - 10.1515/med-2019-0109

DO - 10.1515/med-2019-0109

M3 - SCORING: Journal article

C2 - 31989042

VL - 14

SP - 920

EP - 927

JO - OPEN MED-WARSAW

JF - OPEN MED-WARSAW

SN - 2391-5463

ER -