Children and adolescents with obesity have reduced serum bone turnover markers and 25-hydroxyvitamin D but increased parathyroid hormone concentrations - Results derived from new pediatric reference ranges

Mandy Geserick; Mandy Vogel; Felix Eckelt; Maike Schlingmann; Andreas Hiemisch; Ronny Baber; Joachim Thiery; Antje Körner; Wieland Kieß; Jürgen Kratzsch

doi:10.1016/j.bone.2019.115124

Children and adolescents with obesity have reduced serum bone turnover markers and 25-hydroxyvitamin D but increased parathyroid hormone concentrations - Results derived from new pediatric reference ranges

Standard

Children and adolescents with obesity have reduced serum bone turnover markers and 25-hydroxyvitamin D but increased parathyroid hormone concentrations - Results derived from new pediatric reference ranges. / Geserick, Mandy; Vogel, Mandy; Eckelt, Felix; Schlingmann, Maike; Hiemisch, Andreas; Baber, Ronny; Thiery, Joachim; Körner, Antje; Kieß, Wieland; Kratzsch, Jürgen.

in: BONE, Jahrgang 2020, Nr. 132, 31.12.2019, S. 115-124.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Geserick, M, Vogel, M, Eckelt, F, Schlingmann, M, Hiemisch, A, Baber, R, Thiery, J, Körner, A, Kieß, W & Kratzsch, J 2019, 'Children and adolescents with obesity have reduced serum bone turnover markers and 25-hydroxyvitamin D but increased parathyroid hormone concentrations - Results derived from new pediatric reference ranges', BONE, Jg. 2020, Nr. 132, S. 115-124. https://doi.org/10.1016/j.bone.2019.115124

APA

Geserick, M., Vogel, M., Eckelt, F., Schlingmann, M., Hiemisch, A., Baber, R., Thiery, J., Körner, A., Kieß, W., & Kratzsch, J. (2019). Children and adolescents with obesity have reduced serum bone turnover markers and 25-hydroxyvitamin D but increased parathyroid hormone concentrations - Results derived from new pediatric reference ranges. BONE, 2020(132), 115-124. https://doi.org/10.1016/j.bone.2019.115124

Vancouver

Geserick M, Vogel M, Eckelt F, Schlingmann M, Hiemisch A, Baber R et al. Children and adolescents with obesity have reduced serum bone turnover markers and 25-hydroxyvitamin D but increased parathyroid hormone concentrations - Results derived from new pediatric reference ranges. BONE. 2019 Dez 31;2020(132):115-124. https://doi.org/10.1016/j.bone.2019.115124

Bibtex

@article{dc2447a3d4764cddbd47803ac8a9fa2f,

title = "Children and adolescents with obesity have reduced serum bone turnover markers and 25-hydroxyvitamin D but increased parathyroid hormone concentrations - Results derived from new pediatric reference ranges",

abstract = "Background: We aimed to establish age- and gender-specific reference ranges for concentrations of the bone markers osteocalcin (OC), procollagen type 1 N-propeptides (PINP) and carboxy-terminal cross-linking telopeptide of type 1 collagen (CTX-I) as well as for the calciotropic hormones 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) in healthy infants, children and adolescents. In addition, the effect of age, gender, puberty and body mass index (BMI) on bone markers was investigated.Methods: 2416 healthy subjects (5714 blood withdrawals), aged 3 months to 17 years, were included to estimate the age- and gender-dependence of reference ranges. Subsequently, measured values of the biomarkers were transformed to standard deviation scores (SDS) and their associations with age, gender and puberty were analyzed. Bone marker-SDS values of the reference cohort were compared with an obese cohort (n = 317 and 489 blood withdrawals) to analyze the effect of BMI.Results: OC, PINP and CTX-I showed a distinct age- and gender-dependence with peak levels at 10 to 11 years (girls, Tanner 3) and 13 years (boys, Tanner 3-4). Children with obesity had significantly lower SDS levels for OC (-0.44), PINP (-0.27), CTX-I (-0.33), 25(OH)D (-0.43) and higher SDS levels for PTH (+0.44) than the reference cohort.Conclusions: OC, PINP and CTX-I vary with age, gender and pubertal stage. The body weight status has to be considered in the interpretation of pediatric OC, PINP, CTX-I, 25(OH)D and PTH levels. Consequences of childhood obesity on bone health should be carefully investigated in long-term studies.",

author = "Mandy Geserick and Mandy Vogel and Felix Eckelt and Maike Schlingmann and Andreas Hiemisch and Ronny Baber and Joachim Thiery and Antje K{\"o}rner and Wieland Kie{\ss} and J{\"u}rgen Kratzsch",

year = "2019",

month = dec,

day = "31",

doi = "10.1016/j.bone.2019.115124",

language = "English",

volume = "2020",

pages = "115--124",

journal = "BONE",

issn = "8756-3282",

publisher = "Elsevier Inc.",

number = "132",

}

RIS

TY - JOUR

T1 - Children and adolescents with obesity have reduced serum bone turnover markers and 25-hydroxyvitamin D but increased parathyroid hormone concentrations - Results derived from new pediatric reference ranges

AU - Geserick, Mandy

AU - Vogel, Mandy

AU - Eckelt, Felix

AU - Schlingmann, Maike

AU - Hiemisch, Andreas

AU - Baber, Ronny

AU - Thiery, Joachim

AU - Körner, Antje

AU - Kieß, Wieland

AU - Kratzsch, Jürgen

PY - 2019/12/31

Y1 - 2019/12/31

N2 - Background: We aimed to establish age- and gender-specific reference ranges for concentrations of the bone markers osteocalcin (OC), procollagen type 1 N-propeptides (PINP) and carboxy-terminal cross-linking telopeptide of type 1 collagen (CTX-I) as well as for the calciotropic hormones 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) in healthy infants, children and adolescents. In addition, the effect of age, gender, puberty and body mass index (BMI) on bone markers was investigated.Methods: 2416 healthy subjects (5714 blood withdrawals), aged 3 months to 17 years, were included to estimate the age- and gender-dependence of reference ranges. Subsequently, measured values of the biomarkers were transformed to standard deviation scores (SDS) and their associations with age, gender and puberty were analyzed. Bone marker-SDS values of the reference cohort were compared with an obese cohort (n = 317 and 489 blood withdrawals) to analyze the effect of BMI.Results: OC, PINP and CTX-I showed a distinct age- and gender-dependence with peak levels at 10 to 11 years (girls, Tanner 3) and 13 years (boys, Tanner 3-4). Children with obesity had significantly lower SDS levels for OC (-0.44), PINP (-0.27), CTX-I (-0.33), 25(OH)D (-0.43) and higher SDS levels for PTH (+0.44) than the reference cohort.Conclusions: OC, PINP and CTX-I vary with age, gender and pubertal stage. The body weight status has to be considered in the interpretation of pediatric OC, PINP, CTX-I, 25(OH)D and PTH levels. Consequences of childhood obesity on bone health should be carefully investigated in long-term studies.

AB - Background: We aimed to establish age- and gender-specific reference ranges for concentrations of the bone markers osteocalcin (OC), procollagen type 1 N-propeptides (PINP) and carboxy-terminal cross-linking telopeptide of type 1 collagen (CTX-I) as well as for the calciotropic hormones 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) in healthy infants, children and adolescents. In addition, the effect of age, gender, puberty and body mass index (BMI) on bone markers was investigated.Methods: 2416 healthy subjects (5714 blood withdrawals), aged 3 months to 17 years, were included to estimate the age- and gender-dependence of reference ranges. Subsequently, measured values of the biomarkers were transformed to standard deviation scores (SDS) and their associations with age, gender and puberty were analyzed. Bone marker-SDS values of the reference cohort were compared with an obese cohort (n = 317 and 489 blood withdrawals) to analyze the effect of BMI.Results: OC, PINP and CTX-I showed a distinct age- and gender-dependence with peak levels at 10 to 11 years (girls, Tanner 3) and 13 years (boys, Tanner 3-4). Children with obesity had significantly lower SDS levels for OC (-0.44), PINP (-0.27), CTX-I (-0.33), 25(OH)D (-0.43) and higher SDS levels for PTH (+0.44) than the reference cohort.Conclusions: OC, PINP and CTX-I vary with age, gender and pubertal stage. The body weight status has to be considered in the interpretation of pediatric OC, PINP, CTX-I, 25(OH)D and PTH levels. Consequences of childhood obesity on bone health should be carefully investigated in long-term studies.

U2 - 10.1016/j.bone.2019.115124

DO - 10.1016/j.bone.2019.115124

M3 - SCORING: Journal article

VL - 2020

SP - 115

EP - 124

JO - BONE

JF - BONE

SN - 8756-3282

IS - 132

ER -