Chemokine profile of disc degeneration with acute or chronic pain.
Standard
Chemokine profile of disc degeneration with acute or chronic pain. / Schröder, Malte; Viezens, Lennart; Schäfer, Christian; Friedrichs, Barbara; Algenstaedt, Petra; Ruether, Wolfgang; Wiesner, Lothar; Hansen-Algenstaedt, Nils.
in: J NEUROSURG-SPINE, Jahrgang 18, Nr. 5, 5, 2013, S. 496-503.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Chemokine profile of disc degeneration with acute or chronic pain.
AU - Schröder, Malte
AU - Viezens, Lennart
AU - Schäfer, Christian
AU - Friedrichs, Barbara
AU - Algenstaedt, Petra
AU - Ruether, Wolfgang
AU - Wiesner, Lothar
AU - Hansen-Algenstaedt, Nils
PY - 2013
Y1 - 2013
N2 - Disc-related disorders such as herniation and chronic degenerative disc disease (DDD) are often accompanied by acute or chronic pain. Different mediators have been identified in the development of radicular pain and DDD. Previous studies have not analyzed individual cytokine profiles discriminating between acute sciatic and chronic painful conditions, nor have they distinguished between different anatomical locations within the disc. The aim of this study was to elucidate the protein biochemical mechanisms in DDD.
AB - Disc-related disorders such as herniation and chronic degenerative disc disease (DDD) are often accompanied by acute or chronic pain. Different mediators have been identified in the development of radicular pain and DDD. Previous studies have not analyzed individual cytokine profiles discriminating between acute sciatic and chronic painful conditions, nor have they distinguished between different anatomical locations within the disc. The aim of this study was to elucidate the protein biochemical mechanisms in DDD.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Adolescent
KW - Young Adult
KW - Tumor Necrosis Factor-alpha/biosynthesis
KW - Acute Pain/metabolism
KW - Chemokines/biosynthesis/metabolism
KW - Chronic Pain/enzymology/metabolism
KW - Interleukin-1alpha/biosynthesis
KW - Intervertebral Disc Degeneration/enzymology/metabolism
KW - Intervertebral Disc Displacement/enzymology/metabolism
KW - Matrix Metalloproteinase 3/biosynthesis
KW - Substance P/biosynthesis
KW - Transforming Growth Factor beta/biosynthesis
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Adolescent
KW - Young Adult
KW - Tumor Necrosis Factor-alpha/biosynthesis
KW - Acute Pain/metabolism
KW - Chemokines/biosynthesis/metabolism
KW - Chronic Pain/enzymology/metabolism
KW - Interleukin-1alpha/biosynthesis
KW - Intervertebral Disc Degeneration/enzymology/metabolism
KW - Intervertebral Disc Displacement/enzymology/metabolism
KW - Matrix Metalloproteinase 3/biosynthesis
KW - Substance P/biosynthesis
KW - Transforming Growth Factor beta/biosynthesis
M3 - SCORING: Journal article
VL - 18
SP - 496
EP - 503
JO - J NEUROSURG-SPINE
JF - J NEUROSURG-SPINE
SN - 1547-5654
IS - 5
M1 - 5
ER -