PortalPublikationenCHD1 is a 5q21 tumor suppressor required for ERG rearrangeme...

CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer

Standard

CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer. / Burkhardt, Lia; Fuchs, Sarah; Krohn, Antje; Masser, Sawinee; Mader, Malte; Kluth, Martina; Bachmann, Frederik; Huland, Hartwig; Steuber, Thomas; Graefen, Markus; Schlomm, Thorsten; Minner, Sarah; Sauter, Guido; Sirma, Hüseyin; Simon, Ronald.

in: CANCER RES, Jahrgang 73, Nr. 9, 01.05.2013, S. 2795-805.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Burkhardt, L, Fuchs, S, Krohn, A, Masser, S, Mader, M, Kluth, M, Bachmann, F, Huland, H, Steuber, T, Graefen, M, Schlomm, T, Minner, S, Sauter, G, Sirma, H & Simon, R 2013, 'CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer', CANCER RES, Jg. 73, Nr. 9, S. 2795-805. https://doi.org/10.1158/0008-5472.CAN-12-1342

APA

Burkhardt, L., Fuchs, S., Krohn, A., Masser, S., Mader, M., Kluth, M., Bachmann, F., Huland, H., Steuber, T., Graefen, M., Schlomm, T., Minner, S., Sauter, G., Sirma, H., & Simon, R. (2013). CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer. CANCER RES, 73(9), 2795-805. https://doi.org/10.1158/0008-5472.CAN-12-1342

Vancouver

Burkhardt L, Fuchs S, Krohn A, Masser S, Mader M, Kluth M et al. CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer. CANCER RES. 2013 Mai 1;73(9):2795-805. https://doi.org/10.1158/0008-5472.CAN-12-1342

Bibtex

@article{6c5d23119eb74be9a944eda37329be54,
title = "CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer",
abstract = "Deletions involving the chromosomal band 5q21 are among the most frequent alterations in prostate cancer. Using single-nucleotide polymorphism (SNP) arrays, we mapped a 1.3 megabase minimally deleted region including only the repulsive guidance molecule B (RGMB) and chromodomain helicase DNA-binding protein 1 (CHD1) genes. Functional analyses showed that CHD1 is an essential tumor suppressor. FISH analysis of 2,093 prostate cancers revealed a strong association between CHD1 deletion, prostate-specific antigen (PSA) biochemical failure (P = 0.0038), and absence of ERG fusion (P < 0.0001). We found that inactivation of CHD1 in vitro prevents formation of ERG rearrangements due to impairment of androgen receptor (AR)-dependent transcription, a prerequisite for ERG translocation. CHD1 is required for efficient recruitment of AR to responsive promoters and regulates expression of known AR-responsive tumor suppressor genes, including NKX3-1, FOXO1, and PPARγ. Our study establishes CHD1 as the 5q21 tumor suppressor gene in prostate cancer and shows a key role of this chromatin remodeling factor in prostate cancer biology.",
keywords = "Cell Line, Tumor, Chromosomes, Human, Pair 5, DNA Helicases, DNA-Binding Proteins, Gene Deletion, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Gene Rearrangement, Genes, Tumor Suppressor, Humans, In Situ Hybridization, Fluorescence, Male, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Prostate-Specific Antigen, Prostatic Neoplasms, Receptors, Androgen, Trans-Activators, Translocation, Genetic",
author = "Lia Burkhardt and Sarah Fuchs and Antje Krohn and Sawinee Masser and Malte Mader and Martina Kluth and Frederik Bachmann and Hartwig Huland and Thomas Steuber and Markus Graefen and Thorsten Schlomm and Sarah Minner and Guido Sauter and H{\"u}seyin Sirma and Ronald Simon",
year = "2013",
month = may,
day = "1",
doi = "10.1158/0008-5472.CAN-12-1342",
language = "English",
volume = "73",
pages = "2795--805",
journal = "CANCER RES",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "9",

}

RIS

TY - JOUR

T1 - CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer

AU - Burkhardt, Lia

AU - Fuchs, Sarah

AU - Krohn, Antje

AU - Masser, Sawinee

AU - Mader, Malte

AU - Kluth, Martina

AU - Bachmann, Frederik

AU - Huland, Hartwig

AU - Steuber, Thomas

AU - Graefen, Markus

AU - Schlomm, Thorsten

AU - Minner, Sarah

AU - Sauter, Guido

AU - Sirma, Hüseyin

AU - Simon, Ronald

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Deletions involving the chromosomal band 5q21 are among the most frequent alterations in prostate cancer. Using single-nucleotide polymorphism (SNP) arrays, we mapped a 1.3 megabase minimally deleted region including only the repulsive guidance molecule B (RGMB) and chromodomain helicase DNA-binding protein 1 (CHD1) genes. Functional analyses showed that CHD1 is an essential tumor suppressor. FISH analysis of 2,093 prostate cancers revealed a strong association between CHD1 deletion, prostate-specific antigen (PSA) biochemical failure (P = 0.0038), and absence of ERG fusion (P < 0.0001). We found that inactivation of CHD1 in vitro prevents formation of ERG rearrangements due to impairment of androgen receptor (AR)-dependent transcription, a prerequisite for ERG translocation. CHD1 is required for efficient recruitment of AR to responsive promoters and regulates expression of known AR-responsive tumor suppressor genes, including NKX3-1, FOXO1, and PPARγ. Our study establishes CHD1 as the 5q21 tumor suppressor gene in prostate cancer and shows a key role of this chromatin remodeling factor in prostate cancer biology.

AB - Deletions involving the chromosomal band 5q21 are among the most frequent alterations in prostate cancer. Using single-nucleotide polymorphism (SNP) arrays, we mapped a 1.3 megabase minimally deleted region including only the repulsive guidance molecule B (RGMB) and chromodomain helicase DNA-binding protein 1 (CHD1) genes. Functional analyses showed that CHD1 is an essential tumor suppressor. FISH analysis of 2,093 prostate cancers revealed a strong association between CHD1 deletion, prostate-specific antigen (PSA) biochemical failure (P = 0.0038), and absence of ERG fusion (P < 0.0001). We found that inactivation of CHD1 in vitro prevents formation of ERG rearrangements due to impairment of androgen receptor (AR)-dependent transcription, a prerequisite for ERG translocation. CHD1 is required for efficient recruitment of AR to responsive promoters and regulates expression of known AR-responsive tumor suppressor genes, including NKX3-1, FOXO1, and PPARγ. Our study establishes CHD1 as the 5q21 tumor suppressor gene in prostate cancer and shows a key role of this chromatin remodeling factor in prostate cancer biology.

KW - Cell Line, Tumor

KW - Chromosomes, Human, Pair 5

KW - DNA Helicases

KW - DNA-Binding Proteins

KW - Gene Deletion

KW - Gene Expression Profiling

KW - Gene Expression Regulation, Neoplastic

KW - Gene Rearrangement

KW - Genes, Tumor Suppressor

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Male

KW - Oligonucleotide Array Sequence Analysis

KW - Polymorphism, Single Nucleotide

KW - Prostate-Specific Antigen

KW - Prostatic Neoplasms

KW - Receptors, Androgen

KW - Trans-Activators

KW - Translocation, Genetic

U2 - 10.1158/0008-5472.CAN-12-1342

DO - 10.1158/0008-5472.CAN-12-1342

M3 - SCORING: Journal article

C2 - 23492366

VL - 73

SP - 2795

EP - 2805

JO - CANCER RES

JF - CANCER RES

SN - 0008-5472

IS - 9

ER -