Characterization of visual percepts evoked by noninvasive stimulation of the human posterior parietal cortex.
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Characterization of visual percepts evoked by noninvasive stimulation of the human posterior parietal cortex. / Fried, Peter J; Elkin-Frankston, Seth; Rushmore, Richard Jarrett; Hilgetag, Claus; Valero-Cabre, Antoni.
in: PLOS ONE, Jahrgang 6, Nr. 11, 11, 2011, S. 27204.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Characterization of visual percepts evoked by noninvasive stimulation of the human posterior parietal cortex.
AU - Fried, Peter J
AU - Elkin-Frankston, Seth
AU - Rushmore, Richard Jarrett
AU - Hilgetag, Claus
AU - Valero-Cabre, Antoni
PY - 2011
Y1 - 2011
N2 - Phosphenes are commonly evoked by transcranial magnetic stimulation (TMS) to study the functional organization, connectivity, and excitability of the human visual brain. For years, phosphenes have been documented only from stimulating early visual areas (V1-V3) and a handful of specialized visual regions (V4, V5/MT+) in occipital cortex. Recently, phosphenes were reported after applying TMS to a region of posterior parietal cortex involved in the top-down modulation of visuo-spatial processing. In the present study, we systematically characterized parietal phosphenes to determine if they are generated directly by local mechanisms or emerge through indirect activation of other visual areas. Using technology developed in-house to record the subjective features of phosphenes, we found no systematic differences in the size, shape, location, or frame-of-reference of parietal phosphenes when compared to their occipital counterparts. In a second experiment, discrete deactivation by 1 Hz repetitive TMS yielded a double dissociation: phosphene thresholds increased at the deactivated site without producing a corresponding change at the non-deactivated location. Overall, the commonalities of parietal and occipital phosphenes, and our ability to independently modulate their excitability thresholds, lead us to conclude that they share a common neural basis that is separate from either of the stimulated regions.
AB - Phosphenes are commonly evoked by transcranial magnetic stimulation (TMS) to study the functional organization, connectivity, and excitability of the human visual brain. For years, phosphenes have been documented only from stimulating early visual areas (V1-V3) and a handful of specialized visual regions (V4, V5/MT+) in occipital cortex. Recently, phosphenes were reported after applying TMS to a region of posterior parietal cortex involved in the top-down modulation of visuo-spatial processing. In the present study, we systematically characterized parietal phosphenes to determine if they are generated directly by local mechanisms or emerge through indirect activation of other visual areas. Using technology developed in-house to record the subjective features of phosphenes, we found no systematic differences in the size, shape, location, or frame-of-reference of parietal phosphenes when compared to their occipital counterparts. In a second experiment, discrete deactivation by 1 Hz repetitive TMS yielded a double dissociation: phosphene thresholds increased at the deactivated site without producing a corresponding change at the non-deactivated location. Overall, the commonalities of parietal and occipital phosphenes, and our ability to independently modulate their excitability thresholds, lead us to conclude that they share a common neural basis that is separate from either of the stimulated regions.
KW - Humans
KW - Transcranial Magnetic Stimulation
KW - Visual Perception/physiology
KW - Visual Cortex/physiology
KW - Parietal Lobe/physiology
KW - Phosphenes
KW - Photic Stimulation
KW - Humans
KW - Transcranial Magnetic Stimulation
KW - Visual Perception/physiology
KW - Visual Cortex/physiology
KW - Parietal Lobe/physiology
KW - Phosphenes
KW - Photic Stimulation
U2 - 10.1371/journal.pone.0027204
DO - 10.1371/journal.pone.0027204
M3 - SCORING: Journal article
VL - 6
SP - 27204
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 11
M1 - 11
ER -
