Characterization of the human germ cell nuclear factor gene
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Characterization of the human germ cell nuclear factor gene. / Süsens, U; Borgmeyer, U.
in: Biochim Biophys Acta, Jahrgang 1309, Nr. 3, 11.12.1996, S. 179-82.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Characterization of the human germ cell nuclear factor gene
AU - Süsens, U
AU - Borgmeyer, U
PY - 1996/12/11
Y1 - 1996/12/11
N2 - A cDNA clone encoding the germ cell nuclear factor, GCNF, a member of the nuclear receptor superfamily has been isolated from the human embryonal carcinoma cell line NT2/D1. Sequencing of this clone reveals an open reading frame encoding a 476 amino acid protein. A comparison of the amino acid sequence of the human GCNF with its mouse homologue shows only six amino acid exchanges in the whole protein and a deletion in the amino-terminal region. Northern blot analysis demonstrates that the expression in the testis is conserved.
AB - A cDNA clone encoding the germ cell nuclear factor, GCNF, a member of the nuclear receptor superfamily has been isolated from the human embryonal carcinoma cell line NT2/D1. Sequencing of this clone reveals an open reading frame encoding a 476 amino acid protein. A comparison of the amino acid sequence of the human GCNF with its mouse homologue shows only six amino acid exchanges in the whole protein and a deletion in the amino-terminal region. Northern blot analysis demonstrates that the expression in the testis is conserved.
KW - Amino Acid Sequence
KW - Base Sequence
KW - Blotting, Northern
KW - Cloning, Molecular
KW - DNA, Complementary
KW - DNA-Binding Proteins
KW - Gene Expression Regulation, Developmental
KW - Humans
KW - Molecular Sequence Data
KW - Nuclear Receptor Subfamily 6, Group A, Member 1
KW - Receptors, Cytoplasmic and Nuclear
KW - Sequence Analysis
KW - Sequence Homology, Amino Acid
KW - Tumor Cells, Cultured
M3 - SCORING: Journal article
C2 - 8982251
VL - 1309
SP - 179
EP - 182
JO - Biochim Biophys Acta
JF - Biochim Biophys Acta
SN - 0006-3002
IS - 3
ER -