Characteristics and outcomes of patients with pT4 urothelial carcinoma at radical cystectomy: a retrospective international study of 583 patients.
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Characteristics and outcomes of patients with pT4 urothelial carcinoma at radical cystectomy: a retrospective international study of 583 patients. / Tilki, Derya; Svatek, Robert S; Karakiewicz, Pierre I; Isbarn, Hendrik; Reich, Oliver; Kassouf, Wassim; Fradet, Yves; Novara, Giacomo; Fritsche, Hans-Martin; Bastian, Patrick J; Izawa, Jonathan I; Stief, Christian G; Ficarra, Vincenzo; Lerner, Seth P; Schoenberg, Mark; Dinney, Colin P; Skinner, Eila; Lotan, Yair; Sagalowsky, Arthur I; Shariat, Shahrokh F.
in: J UROLOGY, Jahrgang 183, Nr. 1, 1, 2010, S. 87-93.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Characteristics and outcomes of patients with pT4 urothelial carcinoma at radical cystectomy: a retrospective international study of 583 patients.
AU - Tilki, Derya
AU - Svatek, Robert S
AU - Karakiewicz, Pierre I
AU - Isbarn, Hendrik
AU - Reich, Oliver
AU - Kassouf, Wassim
AU - Fradet, Yves
AU - Novara, Giacomo
AU - Fritsche, Hans-Martin
AU - Bastian, Patrick J
AU - Izawa, Jonathan I
AU - Stief, Christian G
AU - Ficarra, Vincenzo
AU - Lerner, Seth P
AU - Schoenberg, Mark
AU - Dinney, Colin P
AU - Skinner, Eila
AU - Lotan, Yair
AU - Sagalowsky, Arthur I
AU - Shariat, Shahrokh F
PY - 2010
Y1 - 2010
N2 - PURPOSE: We describe cancer specific outcomes in patients with pT4 bladder urothelial carcinoma at radical cystectomy in a large international cohort. MATERIALS AND METHODS: We reviewed the records of 4,257 patients treated with radical cystectomy for bladder urothelial carcinoma at 12 centers. No patient received any preoperative systemic chemotherapy or radiotherapy. RESULTS: Of the 4,257 patients 583 (14%) had pT4 bladder urothelial carcinoma, of whom 83.7% were male, 85.2% had substage pT4a disease, 24.9% had positive soft tissue surgical margins, 57.8% had lymphovascular invasion and 53.5% had lymph node metastasis. Median followup was 55.0 months. Overall estimated 5-year recurrence-free and cancer specific survival was 29% (95% CI 22-32) and 31% (95% CI 25-36), respectively. On multivariate analysis female gender (p = 0.005 and p = 0.001), positive soft tissue surgical margins (p = 0.014 and p
AB - PURPOSE: We describe cancer specific outcomes in patients with pT4 bladder urothelial carcinoma at radical cystectomy in a large international cohort. MATERIALS AND METHODS: We reviewed the records of 4,257 patients treated with radical cystectomy for bladder urothelial carcinoma at 12 centers. No patient received any preoperative systemic chemotherapy or radiotherapy. RESULTS: Of the 4,257 patients 583 (14%) had pT4 bladder urothelial carcinoma, of whom 83.7% were male, 85.2% had substage pT4a disease, 24.9% had positive soft tissue surgical margins, 57.8% had lymphovascular invasion and 53.5% had lymph node metastasis. Median followup was 55.0 months. Overall estimated 5-year recurrence-free and cancer specific survival was 29% (95% CI 22-32) and 31% (95% CI 25-36), respectively. On multivariate analysis female gender (p = 0.005 and p = 0.001), positive soft tissue surgical margins (p = 0.014 and p
M3 - SCORING: Zeitschriftenaufsatz
VL - 183
SP - 87
EP - 93
JO - J UROLOGY
JF - J UROLOGY
SN - 0022-5347
IS - 1
M1 - 1
ER -