Changes in brain microstructure during infancy and childhood using clinical feasible ADC-maps
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Changes in brain microstructure during infancy and childhood using clinical feasible ADC-maps. / Bültmann, Eva; Mußgnug, Hans Joachim; Zapf, Antonia; Hartmann, Hans; Nägele, Thomas; Lanfermann, Heinrich.
in: CHILD NERV SYST, Jahrgang 33, Nr. 5, 05.2017, S. 735-745.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Changes in brain microstructure during infancy and childhood using clinical feasible ADC-maps
AU - Bültmann, Eva
AU - Mußgnug, Hans Joachim
AU - Zapf, Antonia
AU - Hartmann, Hans
AU - Nägele, Thomas
AU - Lanfermann, Heinrich
PY - 2017/5
Y1 - 2017/5
N2 - PURPOSE: The purpose of this study was to examine age-related changes in apparent diffusion coefficient (ADC) during infancy and childhood using routine MRI data.METHODS: A total of 112 investigations of patients aged 0 to 17.2 years showing a normal degree of myelination and no signal abnormalities on conventional MRI were retrospectively selected from our pool of pediatric MRI examinations at 1.5T. ADC maps based on our routinely included axial diffusion weighted sequence were created from the scanner. ADC values were measured in 35 different brain regions investigating normal age-related changes during the maturation of the human brain in infancy and childhood using clinical feasible sequences at 1.5T.RESULTS: The relationship between ADC values and age in infancy and childhood can be described as an exponential function. With increasing age, the ADC values decrease significantly in all brain regions, especially during the first 2 years of life. Except in the peritrigonal white matter, no significant differences were found between both hemispheres. Between 0 and 2 years of life, no significant gender differences were detected.CONCLUSIONS: Using ADC maps based on a routinely performed axial diffusion weighted sequence, it was possible first to describe the relationship between ADC values and age in infancy and childhood as exponential function in the whole brain and second to determine normative age-related ADC values in multiple brain regions.
AB - PURPOSE: The purpose of this study was to examine age-related changes in apparent diffusion coefficient (ADC) during infancy and childhood using routine MRI data.METHODS: A total of 112 investigations of patients aged 0 to 17.2 years showing a normal degree of myelination and no signal abnormalities on conventional MRI were retrospectively selected from our pool of pediatric MRI examinations at 1.5T. ADC maps based on our routinely included axial diffusion weighted sequence were created from the scanner. ADC values were measured in 35 different brain regions investigating normal age-related changes during the maturation of the human brain in infancy and childhood using clinical feasible sequences at 1.5T.RESULTS: The relationship between ADC values and age in infancy and childhood can be described as an exponential function. With increasing age, the ADC values decrease significantly in all brain regions, especially during the first 2 years of life. Except in the peritrigonal white matter, no significant differences were found between both hemispheres. Between 0 and 2 years of life, no significant gender differences were detected.CONCLUSIONS: Using ADC maps based on a routinely performed axial diffusion weighted sequence, it was possible first to describe the relationship between ADC values and age in infancy and childhood as exponential function in the whole brain and second to determine normative age-related ADC values in multiple brain regions.
KW - Adolescent
KW - Age Factors
KW - Brain
KW - Child
KW - Child, Preschool
KW - Diffusion Magnetic Resonance Imaging
KW - Feasibility Studies
KW - Female
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Male
KW - Journal Article
U2 - 10.1007/s00381-017-3391-4
DO - 10.1007/s00381-017-3391-4
M3 - SCORING: Journal article
C2 - 28364169
VL - 33
SP - 735
EP - 745
JO - CHILD NERV SYST
JF - CHILD NERV SYST
SN - 0256-7040
IS - 5
ER -