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c-FOS suppresses ovarian cancer progression by changing adhesion

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c-FOS suppresses ovarian cancer progression by changing adhesion. / Oliveira Ferrer, Leticia; Rößler, K; Haustein, V; Schröder, Christine; Wicklein, D; Maltseva, D; Khaustova, N; Samatov, T; Tonevitsky, A; Mahner, S; Jänicke, F; Schumacher, U; Milde-Langosch, K.

in: BRIT J CANCER, Jahrgang 110, Nr. 3, 04.02.2014, S. 753-63.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Oliveira Ferrer, L, Rößler, K, Haustein, V, Schröder, C, Wicklein, D, Maltseva, D, Khaustova, N, Samatov, T, Tonevitsky, A, Mahner, S, Jänicke, F, Schumacher, U & Milde-Langosch, K 2014, 'c-FOS suppresses ovarian cancer progression by changing adhesion', BRIT J CANCER, Jg. 110, Nr. 3, S. 753-63. https://doi.org/10.1038/bjc.2013.774

APA

Oliveira Ferrer, L., Rößler, K., Haustein, V., Schröder, C., Wicklein, D., Maltseva, D., Khaustova, N., Samatov, T., Tonevitsky, A., Mahner, S., Jänicke, F., Schumacher, U., & Milde-Langosch, K. (2014). c-FOS suppresses ovarian cancer progression by changing adhesion. BRIT J CANCER, 110(3), 753-63. https://doi.org/10.1038/bjc.2013.774

Vancouver

Oliveira Ferrer L, Rößler K, Haustein V, Schröder C, Wicklein D, Maltseva D et al. c-FOS suppresses ovarian cancer progression by changing adhesion. BRIT J CANCER. 2014 Feb 4;110(3):753-63. https://doi.org/10.1038/bjc.2013.774

Bibtex

@article{519d5628435c4d2db98b0759c652e29f,
title = "c-FOS suppresses ovarian cancer progression by changing adhesion",
abstract = "BACKGROUND: C-Fos was initially described as oncogene, but was associated with favourable prognosis in ovarian cancer (OvCa) patients. The molecular and functional aspects underlying this effect are still unknown.METHODS: Using stable transfectants of SKOV3 and OVCAR8 cells, proliferation, migration, invasion and apoptotic potential of c-FOS-overexpressing clones and controls were compared. Adherence to components of the extracellular matrix was analysed in static assays, and adhesion to E-selectin, endothelial and mesothelial cells in dynamic flow assays. The effect of c-FOS in vivo was studied after intraperitoneal injection of SKOV3 clones into SCID mice, and changes in gene expression were determined by microarray analysis.RESULTS: Tumour growth after injection into SCID mice was strongly delayed by c-FOS overexpression, with reduction of lung metastases and circulating tumour cells. In vitro, c-FOS had only weak influence on proliferation and migration, but was strongly pro-apoptotic. Adhesion to components of the extracellular matrix (collagen I, IV) and to E-selectin, endothelial and mesothelial cells was significantly reduced in c-FOS-overexpressing OvCa cells. This corresponds to deregulation of adhesion proteins and glycosylation enzymes in microarray analysis.CONCLUSION: In addition to its known pro-apoptotic effect, c-FOS might influence OvCa progression by changing the adhesion of OvCa cells to peritoneal surfaces.",
keywords = "Animals, Apoptosis, Carcinogenesis, Cell Adhesion, Cell Line, Tumor, Cell Movement, Cell Proliferation, Disease Progression, Extracellular Matrix, Female, Gene Expression Regulation, Neoplastic, Humans, Mice, Neoplasm Invasiveness, Neoplastic Cells, Circulating, Ovarian Neoplasms, Proto-Oncogene Proteins c-fos",
author = "{Oliveira Ferrer}, Leticia and K R{\"o}{\ss}ler and V Haustein and Christine Schr{\"o}der and D Wicklein and D Maltseva and N Khaustova and T Samatov and A Tonevitsky and S Mahner and F J{\"a}nicke and U Schumacher and K Milde-Langosch",
year = "2014",
month = feb,
day = "4",
doi = "10.1038/bjc.2013.774",
language = "English",
volume = "110",
pages = "753--63",
journal = "BRIT J CANCER",
issn = "0007-0920",
publisher = "NATURE PUBLISHING GROUP",
number = "3",

}

RIS

TY - JOUR

T1 - c-FOS suppresses ovarian cancer progression by changing adhesion

AU - Oliveira Ferrer, Leticia

AU - Rößler, K

AU - Haustein, V

AU - Schröder, Christine

AU - Wicklein, D

AU - Maltseva, D

AU - Khaustova, N

AU - Samatov, T

AU - Tonevitsky, A

AU - Mahner, S

AU - Jänicke, F

AU - Schumacher, U

AU - Milde-Langosch, K

PY - 2014/2/4

Y1 - 2014/2/4

N2 - BACKGROUND: C-Fos was initially described as oncogene, but was associated with favourable prognosis in ovarian cancer (OvCa) patients. The molecular and functional aspects underlying this effect are still unknown.METHODS: Using stable transfectants of SKOV3 and OVCAR8 cells, proliferation, migration, invasion and apoptotic potential of c-FOS-overexpressing clones and controls were compared. Adherence to components of the extracellular matrix was analysed in static assays, and adhesion to E-selectin, endothelial and mesothelial cells in dynamic flow assays. The effect of c-FOS in vivo was studied after intraperitoneal injection of SKOV3 clones into SCID mice, and changes in gene expression were determined by microarray analysis.RESULTS: Tumour growth after injection into SCID mice was strongly delayed by c-FOS overexpression, with reduction of lung metastases and circulating tumour cells. In vitro, c-FOS had only weak influence on proliferation and migration, but was strongly pro-apoptotic. Adhesion to components of the extracellular matrix (collagen I, IV) and to E-selectin, endothelial and mesothelial cells was significantly reduced in c-FOS-overexpressing OvCa cells. This corresponds to deregulation of adhesion proteins and glycosylation enzymes in microarray analysis.CONCLUSION: In addition to its known pro-apoptotic effect, c-FOS might influence OvCa progression by changing the adhesion of OvCa cells to peritoneal surfaces.

AB - BACKGROUND: C-Fos was initially described as oncogene, but was associated with favourable prognosis in ovarian cancer (OvCa) patients. The molecular and functional aspects underlying this effect are still unknown.METHODS: Using stable transfectants of SKOV3 and OVCAR8 cells, proliferation, migration, invasion and apoptotic potential of c-FOS-overexpressing clones and controls were compared. Adherence to components of the extracellular matrix was analysed in static assays, and adhesion to E-selectin, endothelial and mesothelial cells in dynamic flow assays. The effect of c-FOS in vivo was studied after intraperitoneal injection of SKOV3 clones into SCID mice, and changes in gene expression were determined by microarray analysis.RESULTS: Tumour growth after injection into SCID mice was strongly delayed by c-FOS overexpression, with reduction of lung metastases and circulating tumour cells. In vitro, c-FOS had only weak influence on proliferation and migration, but was strongly pro-apoptotic. Adhesion to components of the extracellular matrix (collagen I, IV) and to E-selectin, endothelial and mesothelial cells was significantly reduced in c-FOS-overexpressing OvCa cells. This corresponds to deregulation of adhesion proteins and glycosylation enzymes in microarray analysis.CONCLUSION: In addition to its known pro-apoptotic effect, c-FOS might influence OvCa progression by changing the adhesion of OvCa cells to peritoneal surfaces.

KW - Animals

KW - Apoptosis

KW - Carcinogenesis

KW - Cell Adhesion

KW - Cell Line, Tumor

KW - Cell Movement

KW - Cell Proliferation

KW - Disease Progression

KW - Extracellular Matrix

KW - Female

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Mice

KW - Neoplasm Invasiveness

KW - Neoplastic Cells, Circulating

KW - Ovarian Neoplasms

KW - Proto-Oncogene Proteins c-fos

U2 - 10.1038/bjc.2013.774

DO - 10.1038/bjc.2013.774

M3 - SCORING: Journal article

C2 - 24322891

VL - 110

SP - 753

EP - 763

JO - BRIT J CANCER

JF - BRIT J CANCER

SN - 0007-0920

IS - 3

ER -