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Cerebral perfusion impairment correlates with the decrease of CT density in acute ischaemic stroke.

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Cerebral perfusion impairment correlates with the decrease of CT density in acute ischaemic stroke. / Kucinski, Thomas; Majumder, Amitava; Knab, René; Naumann, Dirk; Fiehler, Jens; Väterlein, Ole; Eckert, Bernd; Röther, Joachim; Zeumer, Hermann.

in: NEURORADIOLOGY, Jahrgang 46, Nr. 9, 9, 2004, S. 716-722.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kucinski, T, Majumder, A, Knab, R, Naumann, D, Fiehler, J, Väterlein, O, Eckert, B, Röther, J & Zeumer, H 2004, 'Cerebral perfusion impairment correlates with the decrease of CT density in acute ischaemic stroke.', NEURORADIOLOGY, Jg. 46, Nr. 9, 9, S. 716-722. <http://www.ncbi.nlm.nih.gov/pubmed/15221155?dopt=Citation>

APA

Kucinski, T., Majumder, A., Knab, R., Naumann, D., Fiehler, J., Väterlein, O., Eckert, B., Röther, J., & Zeumer, H. (2004). Cerebral perfusion impairment correlates with the decrease of CT density in acute ischaemic stroke. NEURORADIOLOGY, 46(9), 716-722. [9]. http://www.ncbi.nlm.nih.gov/pubmed/15221155?dopt=Citation

Vancouver

Kucinski T, Majumder A, Knab R, Naumann D, Fiehler J, Väterlein O et al. Cerebral perfusion impairment correlates with the decrease of CT density in acute ischaemic stroke. NEURORADIOLOGY. 2004;46(9):716-722. 9.

Bibtex

@article{dac39925f6a6458fa00e9a43e1f1d483,
title = "Cerebral perfusion impairment correlates with the decrease of CT density in acute ischaemic stroke.",
abstract = "Within the first 6 h of ischaemic stroke, changes on computed tomography (CT) scans are known as early ischaemic signs. We tested the hypothesis that the severity of perfusion impairment correlates with the degree of CT density decrease. Water uptake in ischaemic brain tissue results in a subtle decrease of CT density, and was quantified by delineation of the corresponding decrease of the apparent diffusion coefficient (ADC). Regions of decreased ADC and CT density in 29 acute-stroke patients were superimposed on the corresponding magnetic resonance perfusion images. Mean values of ADC and CT density decrease were correlated with the corresponding relative changes of cerebral blood flow (rCBF) and volume (rCBV), mean transit time (rMTT) and time-to-peak (rTTP). The decrease of CT density was 1.2 +/- 0.6 Hounsfield units and showed a linear correlation with rCBF (0.42, p <0.01) as well as rCBV (0.62, p <0.01), but not with the prolongation of rMTT (1.43, p = 0.78) or rTTP (1.34, p = 0.26). Therefore, the reduction of rCBF determines the severity of the early ischaemic oedema (EIOE) on CT, as well as reduction of the ADC. These findings provide a coherent view on the pathophysiology of the EIOE.",
author = "Thomas Kucinski and Amitava Majumder and Ren{\'e} Knab and Dirk Naumann and Jens Fiehler and Ole V{\"a}terlein and Bernd Eckert and Joachim R{\"o}ther and Hermann Zeumer",
year = "2004",
language = "Deutsch",
volume = "46",
pages = "716--722",
journal = "NEURORADIOLOGY",
issn = "0028-3940",
publisher = "Springer",
number = "9",

}

RIS

TY - JOUR

T1 - Cerebral perfusion impairment correlates with the decrease of CT density in acute ischaemic stroke.

AU - Kucinski, Thomas

AU - Majumder, Amitava

AU - Knab, René

AU - Naumann, Dirk

AU - Fiehler, Jens

AU - Väterlein, Ole

AU - Eckert, Bernd

AU - Röther, Joachim

AU - Zeumer, Hermann

PY - 2004

Y1 - 2004

N2 - Within the first 6 h of ischaemic stroke, changes on computed tomography (CT) scans are known as early ischaemic signs. We tested the hypothesis that the severity of perfusion impairment correlates with the degree of CT density decrease. Water uptake in ischaemic brain tissue results in a subtle decrease of CT density, and was quantified by delineation of the corresponding decrease of the apparent diffusion coefficient (ADC). Regions of decreased ADC and CT density in 29 acute-stroke patients were superimposed on the corresponding magnetic resonance perfusion images. Mean values of ADC and CT density decrease were correlated with the corresponding relative changes of cerebral blood flow (rCBF) and volume (rCBV), mean transit time (rMTT) and time-to-peak (rTTP). The decrease of CT density was 1.2 +/- 0.6 Hounsfield units and showed a linear correlation with rCBF (0.42, p <0.01) as well as rCBV (0.62, p <0.01), but not with the prolongation of rMTT (1.43, p = 0.78) or rTTP (1.34, p = 0.26). Therefore, the reduction of rCBF determines the severity of the early ischaemic oedema (EIOE) on CT, as well as reduction of the ADC. These findings provide a coherent view on the pathophysiology of the EIOE.

AB - Within the first 6 h of ischaemic stroke, changes on computed tomography (CT) scans are known as early ischaemic signs. We tested the hypothesis that the severity of perfusion impairment correlates with the degree of CT density decrease. Water uptake in ischaemic brain tissue results in a subtle decrease of CT density, and was quantified by delineation of the corresponding decrease of the apparent diffusion coefficient (ADC). Regions of decreased ADC and CT density in 29 acute-stroke patients were superimposed on the corresponding magnetic resonance perfusion images. Mean values of ADC and CT density decrease were correlated with the corresponding relative changes of cerebral blood flow (rCBF) and volume (rCBV), mean transit time (rMTT) and time-to-peak (rTTP). The decrease of CT density was 1.2 +/- 0.6 Hounsfield units and showed a linear correlation with rCBF (0.42, p <0.01) as well as rCBV (0.62, p <0.01), but not with the prolongation of rMTT (1.43, p = 0.78) or rTTP (1.34, p = 0.26). Therefore, the reduction of rCBF determines the severity of the early ischaemic oedema (EIOE) on CT, as well as reduction of the ADC. These findings provide a coherent view on the pathophysiology of the EIOE.

M3 - SCORING: Zeitschriftenaufsatz

VL - 46

SP - 716

EP - 722

JO - NEURORADIOLOGY

JF - NEURORADIOLOGY

SN - 0028-3940

IS - 9

M1 - 9

ER -